Structure and Function of High Endothelial Postcapillary Venules in Lymphocyte Circulation
The interdependence of the tissue and organ components that constitute the immune system is maintained and controlled by continuous interorgan lymphocyte traffic via the circulation. This lymphocyte traffic is accompanied by differentiations of lymphocytes into lymphocytes with different qualities of immunocompetency and in this way determines the immune responses of the tissues and organs involved. This interorgan traffic is clearly not a random event. Specific and selective factors determine its high degree of organization. In their movement from one anatomical site to another, the lymphocytes cross endothelial barriers. The specificities involved in the interaction between lymphocytes and the endothelia concerned and which result in the selective lymphocyte transmural passage are the essential regulatory factors in the interorgan traffic of lymphocytes.
KeywordsMouse Lymph Node Peripheral Lymph Node High Endothelial Venule Postcapillary Venule Lymphocyte Homing
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