Skip to main content
SpringerLink
Log in

Low-Density Lipoprotein Receptors

  • Chapter
Cell Receptors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 83))

Abstract

The origins of the receptor theory are based on the work of Paul Ehrlich (1854–1915) and John Newport Langley (1852–1925) (Parascandola 1981), who were the first to postulate that specific cellular reactions to drugs must be based on so-called receptive substances. Receptors are proteins that specifically bind and take up hormones, growth factors, transport proteins, viruses, and toxins. The understanding of the physiological effects that are caused by certain ligands depends to a considerable extent on knowledge of where the target cells are located and how they interact with their ligands. In Chap. 4 of this book, M. Dietel reviews the different locations of cell receptors with special reference to morphological and biochemical aspects. This chapter focuses on specific receptors for low-density lipoproteins (LDL).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alexopoulos CG, Blatsios B, Avgerinos A (1987) Serum lipids and lipoprotein disorders in cancer patients. Cancer 60:3065–3070

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW (1986) Methods for visualization of the LDL pathway in cultured fibroblasts. Methods Enzymol 129:201–216

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW, Goldstein JL, Brown MS (1976) Localization of low density lipoprotein receptors on plasma membranes of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. Proc Natl Acad Sci USA 73:2434–2438

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW, Brown MS, Goldstein JL (1977a) Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell 10:351–364

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW, Goldstein JL, Brown MS (1977b) A mutation that impairs the ability of lipoprotein receptors to localize in coated pits on the cell surface of human fibroblasts. Nature 270:695–699

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW, Vasile E, Mello RJ, Brown MS, Goldstein JL (1978) Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution. Cell 15:919–933

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW, Goldstein JL, Brown MS (1980) Fluorescence visualization of receptor-bound low density lipoprotein in human fibroblasts. J Recept Res 1:17–39

    PubMed  CAS  Google Scholar 

  • Anderson RGW, Brown MS, Goldstein JL (1981) Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells. J Cell Biol 88:441–452

    Article  PubMed  CAS  Google Scholar 

  • Anderson RGW, Brown MS, Beisiegel U, Goldstein JL (1982) Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies. J Cell Biol 93:523–531

    Article  PubMed  CAS  Google Scholar 

  • Balasubramaniam S, Goldstein JL, Brown MS (1977) Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. Proc Natl Acad Sci USA 74:1421–1425

    Article  PubMed  CAS  Google Scholar 

  • Barak LS, Webb WW (1981) Fluorescent low density lipoprotein for observation of dynamics of individual receptor complexes on cultured human fibroblasts. J Cell Biol 90:595–604

    Article  PubMed  CAS  Google Scholar 

  • Barak LS, Webb WW (1982) Diffusion of low density lipoprotein-receptor complex on human fibroblasts. J Cell Biol 95:846–852

    Article  PubMed  CAS  Google Scholar 

  • Basu SK, Goldstein JL, Brown MS (1978) Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts. J Biol Chem 253:3852–3856

    PubMed  CAS  Google Scholar 

  • Beaglehole R, Foulkes MA, Prior IAM, Eyles EF (1980) Cholesterol and mortality in New Zealand Maoris. Br Med J II:285–287

    Article  Google Scholar 

  • Beisiegel U, Kita T, Anderson RGW, Schneider WJ, Brown MS, Goldstein JL (1981a) Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver. J Biol Chem 256:4071–4078

    PubMed  CAS  Google Scholar 

  • Beisiegel U, Schneider WJ, Goldstein JL, Anderson RGW, Brown MS (1981b) Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor mediated endo-cytosis and the genetics of familial hypercholesterolemia. J Biol Chem 256:11923–11931

    PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1981) Lowering plasma cholesterol by raising LDL receptors. N Engl J Med 305:515–517

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1986) A receptor mediated pathway for cholesterol homeostasis. Science 232:34–47

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Faust JR, Goldstein JL (1975) Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. J Clin Invest 55:783–793

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Ho YK, Goldstein JL (1976) The low-density lipoprotein pathway in human fibroblasts: relation between cell surface receptor binding and endocytosis of low-density lipoprotein. Ann NY Acad Sci USA 68:244–247

    Article  Google Scholar 

  • Brown MS, Anderson RGW, Basu SK, Goldstein JL (1982) Recycling of cell-surface receptors: observations from the LDL receptor system. Cold Spring Harbor Symp Quant Biol XLVI:713–721

    Google Scholar 

  • Brown MS, Anderson RGW, Goldstein JL (1983) Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell 32:663–667

    Article  PubMed  CAS  Google Scholar 

  • Carew TE, Schwenke DC, Steinberg D (1987) Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 84:7725–7729

    Article  PubMed  CAS  Google Scholar 

  • Clayman RV, Bilhartz LE, Buja ML, Spady DK, Dietschy JM (1986a) Renal cell carcinoma in the Wistar rat: a model for studying the mechanism of cholesterol acquisition by a tumor in vivo. Cancer Res 46:2958–2963

    PubMed  CAS  Google Scholar 

  • Clayman RV, Bilhartz LE, Spady DK, Buja ML, Dietschy JM (1986b) Low density lipoprotein receptor activity is lost in vivo in malignant transformed renal tissue. FEBS Lett 196:87–90

    Article  PubMed  CAS  Google Scholar 

  • Davies PF, Reidy MA, Goode TB, Bowyer TE (1976) Scanning electron microscopy in the evaluation of endothelial integrity of the fatty lesion in atherosclerosis. Atherosclerosis 25:125–130

    Article  PubMed  CAS  Google Scholar 

  • Dawson P, Hofman SL, Westhuyzen DR, Südhoff TC, Brown MS, Goldstein JL (1988) Sterol dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor spi. J Biol Chem 263:3372–3379

    PubMed  CAS  Google Scholar 

  • Dawson P, Westhuyzen DR, Goldstein JL, Brown MS (1989) Purification of oxysterol binding protein from hamster liver cytosol. J Biol Chem 264:9046–9052

    PubMed  CAS  Google Scholar 

  • Eckel RH (1989) Lipoprotein lipase: a multifunctional enzyme relevant to common metabolic disease. N Engl J Med 320:1060–1068

    Article  PubMed  CAS  Google Scholar 

  • Esterbauer H, Quehenberger O, Jürgens G (1988) Effect of peroxidative conditions on human plasma low density lipoproteins. In: Nigam SK, Brien DCH, Slater TF (eds) Eicosanoids, lipidperoxidation and cancer. Springer, Berlin Heidelberg New York, pp 203–213

    Google Scholar 

  • Feinleib M (1983) Review of the epidemiological evidence for a possible relationship between hypocholesterolemia and cancer. Cancer Res 43:2503–2507

    Google Scholar 

  • Firestone RA, Pisano JM, Falck JR, McPhaul MM, Krieger M (1984) Selective delivery of cytotoxic compounds to cells by the LDL pathway. J Med Chem 27:1037–1043

    Article  PubMed  CAS  Google Scholar 

  • Fukuda S, Horiuchi S, Tornita K, Murakami M, Morino Y, Takahashi K (1986) Acetylated low-density lipoprotein is endocytosed through coated pits by rat peritoneal macrophages. Virchows Arch [B] 52:1–13

    Article  CAS  Google Scholar 

  • Gal D, MacDonald PC, Porter JC, Simpson ER (1981a) Cholesterol metabolism in cancer cells in monolayer culture. III. Low-density lipoprotein metabolism. Int J Cancer 28:315–319

    Article  PubMed  CAS  Google Scholar 

  • Gal D, MacDonald PC, Porter JC, Smith JW, Simpson ER (1981b) Effect of cell density and confluency on cholesterol metabolism in cancer cells in monolayer culture. Cancer Res 41:473–477

    PubMed  CAS  Google Scholar 

  • Garcia-Palmieri MR, Sorlie PD, Costas R, Havlik RJ (1981) An apparent inverse relationship between serum cholesterol and cancer mortality in Puerto Rico. Am J Epidermiol 114:29–40

    CAS  Google Scholar 

  • Geuze HJ, Slot JW, Strous GJAM, Peppard J, von Figura K, Hasilik A, Schwartz AL (1983) Intracellular site of asialoglycoprotein receptor-ligand uncoupling. Double label immunoelectronmicroscopy during receptor mediated endocytosis. Cell 35:277–287

    Article  Google Scholar 

  • Ginsberg H, Gilbert HS, Gibson JC, Le NA, Brown WV (1982) Increased low-density lipoprotein catabolism in myeloproliferative disorders. Ann Intern Med 96:311–316

    PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS (1973) Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc Natl Acad Sci USA 70:2804–2808

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS, Anderson RGW (1977) The low density lipoprotein pathway in human fibroblasts. In: Brinkley BR, Porter KR (eds) International cell biology. Rockefeller University Press, New York, pp 639–648

    Google Scholar 

  • Goldstein JL, Anderson RGW, Brown MS (1979a) Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 279:679–685

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Helgeson JAS, Brown MS (1979b) Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor. J Biol Chem 254:5403–5409

    PubMed  CAS  Google Scholar 

  • Goldstein JL, Ho YK, Basu SK, Brown MS (1979c) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 76:333–337

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Kita T, Brown MS (1983) Defective lipoprotein receptors and atherosclerosis: lessons from an animal counterpart of familial hypercholesterolemia. N Engl J Med 309:288–295

    Article  PubMed  CAS  Google Scholar 

  • Gross D, Webb WW (1986) Molecular counting of low-density lipoprotein particles as individuals and small clusters on cell surfaces. Biophys J 49:901–911

    Article  PubMed  CAS  Google Scholar 

  • Haberland ME, Fong D, Cheng L (1988) Malondialdehyde-altered atheroma of Watanabe heritable hyperlipidemic rabbits. Science 241:215–218

    Article  PubMed  CAS  Google Scholar 

  • Handley DA, Arbeeny CM, Witte LD, Chien S (1981a) Colloidal gold-low density lipoprotein conjugates as membrane receptor probes. Proc Natl Acad Sci USA 78:368–371

    Article  PubMed  CAS  Google Scholar 

  • Handley DA, Arbeeny CM, Eder HA, Chien S (1981b) Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17α-ethinylestradiol. J Cell Biol 90:778–787

    Article  PubMed  CAS  Google Scholar 

  • Havel RJ, Goldstein JL, Brown MS (1980) Lipoproteins and lipid transport. In: Bondy PK, Rosenberg LE (eds) Metabolic control and disease, 8th edn. WB Saunders, Philadelphia, pp 393–494

    Google Scholar 

  • Helenius A, Mellman I, Wall D, Hubbard A (1983) Endosomes. Trends Biochem Sci 8:245–250

    Article  CAS  Google Scholar 

  • Hesz A, Ingolic E, Krempler F, Kostner GM (1987) The existence of B/E and E receptors on HEP-G2 cells: a study using colloidal gold- and 125I-labeled lipoproteins. Exp Mol Pathol 46:372–382

    Article  PubMed  CAS  Google Scholar 

  • International Collaborative Group (1982) Circulating cholesterol level and risk of death from cancer in men aged 40 to 69 years. JAMA 248:2853–2859

    Article  Google Scholar 

  • Jaeckle S, Brady SE, Havel RJ (1989) Membrane liver binding sites for plasma lipoproteins on endosomes from rat liver. Proc Natl Acad Sci USA 86:1880–1884

    Article  PubMed  CAS  Google Scholar 

  • Kagan A, McGee DL, Yano K, Rhoads GG, Nomura A (1981) Serum cholesterol and mortality in a Japanese-American population — the Honolulu heart program. Am J Epidemiol 114:11–20

    PubMed  CAS  Google Scholar 

  • Kark JD, Smith AH, Hames CG (1980) The relationship of serum cholesterol to the incidence of cancer in Evans County, Georgia. J Chronic Dis 33:311–322

    Article  PubMed  CAS  Google Scholar 

  • Kita T, Nagano Y, Yokode M et al. (1987) Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci USA 84:5928–5931

    Article  PubMed  CAS  Google Scholar 

  • Knott TJ, Pease RJ, Powell LM et al. (1986) Complete protein sequence and identification of structural domains of human apo-lipoprotein B. Nature 323:734–738

    Article  PubMed  CAS  Google Scholar 

  • Kovanen PT, Faust JR, Brown MS, Goldstein JL (1979a) Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells. Endocrinology 104:599–609

    Article  PubMed  CAS  Google Scholar 

  • Kovanen PT, Basu SK, Goldstein JL, Brown MS (1979b) Low density lipoprotein receptors in bovine adrenal cortex. II. Low density lipoprotein binding to membranes prepared from fresh tissue. Endocrinology 104:610–616

    Article  PubMed  CAS  Google Scholar 

  • Kreiger M, Smith LC, Anderson RG et al. (1979) Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells. J Supramol Struct 10:467–478

    Article  Google Scholar 

  • Kreiger M, Brown MS, Faust JR, Goldstein JL (1978) Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. J Biol Chem 129:4093–4101

    Google Scholar 

  • Kruth HS, Avigan J, Gamble W, Vaughan M (1979) Effect of cell density on binding and uptake of low density lipoprotein by human fibroblasts. J Cell Biol 83:588–594

    Article  PubMed  CAS  Google Scholar 

  • Law SW, Grant SM, Higuchi K, Hospattankar A, Lackner K, Lee N, Brewer HB (1986) Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence. Proc Natl Acad Sci USA 83:8142–8146

    Article  PubMed  CAS  Google Scholar 

  • Malassiné A, Besse C, Roche A, Alsat E, Rebourcet R, Mondon F, Cedard L (1987) Ultrastructural visualization of the internalization of low density lipoprotein by human placental cells. Histochemistry 87:457–464

    Article  PubMed  Google Scholar 

  • Mommaas-Kienhuis AM, Krijbolder LH, van Hinsbergh VWM, Daems WT, Vermeer BJ (1985a) Visualizing of binding and receptor-mediated uptake of low density lipoproteins by human endothelial cells. Eur J Cell Biol 36:201–208

    PubMed  CAS  Google Scholar 

  • Mommaas-Kienhuis AM, van der Schroeff JG, Wijsman MC, Daems WT, Vermeer BJ (1985b) Conjugates of colloidal gold with native and acetylated low density lipoproteins for ultrastructural investigations on receptor-mediated endocytosis by cultured human monocyte-derived macrophages. Histochemistry 83:29–35

    Article  PubMed  CAS  Google Scholar 

  • Morris DL, Borhani NO, Fitzsimons E et al. (1983) Serum cholesterol and cancer in the hypertension detection and follow-up program. Cancer 52:1754–1759

    Article  PubMed  CAS  Google Scholar 

  • Niendorf A, Röcken C, Hupfeld S et al. (1988) Morphologische und funktionelle Bedeutung von LDL-Rezeptoren an malignen Tumoren. Verh Dtsch Ges Pathol 72:427

    Google Scholar 

  • Niendorf A, Hupfeld S, Keilhau A, Peters A, Arps H, Beisiegel U, Dietel M (1989a) HMG-CoA-Reductase-Inhibition hemmt das Wachstum von kultivierten Coloncarcinomzellen. Verh Dtsch Ges Pathol 73:459

    Google Scholar 

  • Niendorf A, Peters A, Keilhau A, Arps H, Behnke B, Beisiegel U, Dietel M (1989b) LDL deficiency and suppression of HMG-CoA-reductase activity cause inhibition of proliferation rates in mammary carcinoma cells in vitro. Proceedings of the 80th annual meeting of the American Association for Cancer Research 30:80 (abstr)

    Google Scholar 

  • Nistor A, Simionescu M (1986) Uptake of low density lipoproteins by the hamster lung — interactions with capillary endothelium. Am Rev Respir Dis 134:1266–1272

    PubMed  CAS  Google Scholar 

  • Osborne TF, Gil G, Goldstein JL, Brown MS (1988) Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding sterol regulator element. J Biol Chem 263:3380–3387

    PubMed  CAS  Google Scholar 

  • Paavola LG, Strauss JF, Boyd CO, Nestler JE (1985) Uptake of gold- and [3H]cholesteryl linoleate-labeled human low density lipoprotein by cultured rat granulosa cells: cellular mechanisms involved in lipoprotein metabolism and their importance to steroidogenesis. J Cell Biol 100:1235–1247

    Article  PubMed  CAS  Google Scholar 

  • Parascandola J (1981) Origins of the receptor theory. In: Lamble W (ed) Towards understanding receptors. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 1–7

    Google Scholar 

  • Pastan IH, Willingham MC (1981) Journey to the center of the cell: role of the receptosome. Science 214:504–509

    Article  PubMed  CAS  Google Scholar 

  • Pathak RK, Merkle RK, Cummings RD, Goldstein JL, Brown MS, Anderson RGW (1988) Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex. J Cell Biol 106:1831–1841

    Article  PubMed  CAS  Google Scholar 

  • Pearse BMF (1975) Coated vesicles from pig brain: purification and biochemical characterization. J Mol Biol 97:93–98

    Article  PubMed  CAS  Google Scholar 

  • Pearse BMF (1976) Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles. Proc Natl Acad Sci USA 73:1255–1259

    Article  PubMed  CAS  Google Scholar 

  • Pitas RE, Boyles J, Mahley RW, Montgomery Bissell D (1985) Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol 100:103–117

    Article  PubMed  CAS  Google Scholar 

  • Reverter JC, Sierra J, Marti-Tutusaus, Montserrrat E, Granena A, Rozman C (1988) Hypocholesterolemia in acute myelogenous leukemia. Eur J Haematol 41:317–320

    Article  PubMed  CAS  Google Scholar 

  • Roach PD, Zollinger M, Noel SP (1987) Detection of the low density lipoprotein (LDL) receptor on nitrocellulose paper with colloidal gold-LDL conjugates. J Lipid Res 28:1515–1521

    PubMed  CAS  Google Scholar 

  • Robenek A, Hesz A (1983) Dynamics of low-density lipoprotein receptors in the plasma membrane of cultured human skin fibroblasts as visualized by colloidal gold in conjunction with surface replicas. Eur J Cell Biol 31:275–282

    PubMed  CAS  Google Scholar 

  • Robenek H, Rassat J, Hesz A, Grünwald J (1982) A correlative study on the topographical distribution of the receptors for low density lipoprotein (LDL) conjugated to colloidal gold in cultured human skin fibroblasts employing thin section, freeze-fracture, deep-etching, and surface replication techniques. Eur J Cell Biol 27:242–250

    PubMed  CAS  Google Scholar 

  • Robenek H, Hesz A, Rassat J (1983) Variability of the topography of low-density lipoprotein (LDL) receptors in the plasma membrane of cultured human skin fibroblasts as revealed by gold-LDL conjugates in conjunction with the surface replication technique. J Ultrastruct Res 82:143–155

    Article  PubMed  CAS  Google Scholar 

  • Rose G, Shipley MJ (1980) Plasma lipids and mortality: a source of error. Lancet 1:523–526

    Article  PubMed  CAS  Google Scholar 

  • Ross R (1986) The pathogenesis of atherosclerosis — an update. N Engl J Med 314:488–500

    Article  PubMed  CAS  Google Scholar 

  • Rotheneder M, Kostner GM (1989) Effects of low- and high-density lipoproteins on the proliferation of human breast cancer cells in vitro: differences between hormone-dependent and hormone-independent cell lines. Int J Cancer 43:875–879

    Article  PubMed  CAS  Google Scholar 

  • Rudling M (1986) Low density lipoprotein receptors in normal and malignant tissues: physiological aspects and clinical significance. Akademisk Avhandling, Department of Pharmacology, Karolinska Institute, Stockholm, Sweden

    Google Scholar 

  • Rudling MJ, Collins VP, Peterson CO (1983) Delivery of aclacinomycin A to human glioma cells in vitro by the low-density lipoprotein pathway. Cancer Res 43:4600–4605

    PubMed  CAS  Google Scholar 

  • Rudling MJ, Stahle L, Peterson CO, Skoog L (1986) Content of low density lipoprotein receptors in breast cancer tissue related to survival of patients. Br Med J 292:580–582

    Article  CAS  Google Scholar 

  • Russel DW, Yamamoto T, Schneider WJ, Slaughter CJ, Brown MS, Goldstein JL (1983) cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA. Proc Natl Acad Sci USA 50:7501–7505

    Article  Google Scholar 

  • Sanan DA, Strümpfer AEM, van der Westhuyzen DR, Coetzee GA (1985) Native and acetylated low density lipoprotein metabolism in proliferating and quiescent bovine endothelial cells in culture. Eur J Cell Biol 36:81–90

    PubMed  CAS  Google Scholar 

  • Sanan DA, Van der Westhuyzen DR, Gevers W, Coetzee GA (1987) The surface distribution of low density lipoprotein receptors on cultured fibroblasts and endothelial cells — ultrastructural evidence for dispersed receptors. Histochemistry 86:517–523

    Article  PubMed  CAS  Google Scholar 

  • Schatzkin A, Hoover RN, Taylor PR et al. (1988) Site-specific analysis of total serum cholesterol and incident cancer in the national health and nutrition examination survey. I. Epidemiologic follow-up study. Cancer Res 48:452–458

    PubMed  CAS  Google Scholar 

  • Schneider WJ, Basu SK, McPhaul MJ, Goldstein JL, Brown MS (1979) Solubilization of the low density lipoprotein receptor. Proc Natl Acad Sci USA 76:5577–5581

    Article  PubMed  CAS  Google Scholar 

  • Schneider WJ, Goldstein JL, Brown MS (1980) Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex. J Biol Chem 255:11442–11447

    PubMed  CAS  Google Scholar 

  • Schneider WJ, Beisiegel U, Goldstein JL, Brown MS (1982) Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164000 molecular weight. J Biol Chem 257:2664–2673

    PubMed  CAS  Google Scholar 

  • Sherwin RW, Wentworth DN, Cutler JA, Hulley SB, Kuller LH, Stamler J (1987) Serum cholesterol levels and cancer mortality in 361 662 men screened for the multiple risk factor intervention trial. JAMA 257:943–948

    Article  PubMed  CAS  Google Scholar 

  • Snelting-Havinga I, Mommaas M, Van Hinsbergh VWM, Daha MR, Daems WT, Vermeer BJ (1989) Immunoelectron microscopic visualization of the transcytosis of low density lipoproteins in perfused rat arteries. Eur J Cell Biol 48:27–36

    PubMed  CAS  Google Scholar 

  • Sparrow CP, Parthasarathy S, Steinberg D (1989) A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein. J Biol Chem 264:2599–2604

    PubMed  CAS  Google Scholar 

  • Stary H (1989) Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis 9:119–132

    Google Scholar 

  • Steinberg D, Parthasarathy S, Carew T, Khoo JC, Witzum JL (1989) Beyond cholesterol modification of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320:915–924

    Article  PubMed  CAS  Google Scholar 

  • Study Group, European Atherosclerosis Society (1987) Strategies for the prevention of coronary heart disease: a policy statement of the European Atherosclerosis Society. Eur Heart J 8:77–88

    Google Scholar 

  • Südhof TC, Goldstein JL, Brown MS, Rüssel DW (1985) The ldl receptor gene: a mosaic of exons shared with different proteins. Science 228:815–822

    Article  PubMed  Google Scholar 

  • Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL (1983) The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor. Cell 32:941–951

    Article  PubMed  CAS  Google Scholar 

  • Tompkins RG, Schnitzer JJ, Yarmush ML, Colton CK, Smith KA (1988) Measurement of 125I-low density lipoprotein uptake in selected tissues of the squirrel monkey by quantitative autoradiography. Am J Pathol 132:526–542

    PubMed  CAS  Google Scholar 

  • Törnberg SA, Holm LE, Carstensen JM, Eklund GA, Odont D (1986) Risks of cancer of the colon and rectum in relation to serum cholesterol and beta-lipoprotein. N Engl J Med 315:1629–1633

    Article  PubMed  Google Scholar 

  • Tóth IE, Szabó D, Szalay KS, Gyévai A, Szollâr LG, Glaz E (1988) Colloidal gold-labeled lipoprotein binding and internalization in adrenocortical cells in vitro. Clin Biochem 21:101–105

    Article  PubMed  Google Scholar 

  • Vasile E, Simionescu M, Simionescu N (1983) Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ. J Cell Biol 96:1677–1689

    Article  PubMed  CAS  Google Scholar 

  • Ventkatanarayanan S, Nagarajan B (1988) Association between tumour status and serum lipoprotein cholesterol in hemopoietic malignancy. Biochem Int 17:499–507

    Google Scholar 

  • Vermeer BJ, Wijsman MC, Mommaas-Kienhuis AM, Ponec M, Havekes L (1985) Modulation of low density lipoprotein receptor activity in squamous carcinoma cells by variation in cell density. Eur J Cell Biol 38:353–360

    PubMed  CAS  Google Scholar 

  • Vermeer BJ, Wijsman MC, Mommaas-Kienhuis AM, Ponec M (1986) Binding and internalization of low-density lipoproteins in SCC25 cells and SV40 transformed keratinocytes. A morphologic study. J Invest Dermatol 86:195–200

    Article  PubMed  CAS  Google Scholar 

  • Vitols S, Gahrton G, Peterson C (1984) Significance of the low density lipoprotein (LDL) receptor pathway for the in vitro accumulation of AD-32 incorporated into LDL in normal and leukemic white blood cells. Cancer Treat Rep 68:515–520

    PubMed  CAS  Google Scholar 

  • Vitols SG, Masquelier M, Peterson CO (1985) Selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts. J Med Chem 28:451–454

    Article  PubMed  CAS  Google Scholar 

  • Weisgraber KH, Rail SC Jr (1987) Human apolipoprotein B-100 heparin-binding sites. J Biol Chem 262:11097–11103

    PubMed  CAS  Google Scholar 

  • Williams ML, Mommaas-Kienhuis AM, Rutherford SL, Grayson S, Vermeer BJ, Elias PM (1987) Free sterol metabolism and low density lipoprotein receptor expression as differentiation markers of cultured human keratinocytes. J Cell Physiol 132:428–440

    Article  PubMed  CAS  Google Scholar 

  • Williams RR, Sorlie PD, Feinleib M, McNamara PM, Kannel WB, Dawber TR (1981) Cancer incidence by levels of cholesterol. JAMA 245:247–252

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization (1958) Classification of atherosclerotic lesions; report of a study group. World Health Organization Technical Report Series No. 143 3–20

    Google Scholar 

  • Yang CY, Chen SH, Gianturco SH et al. (1986) Sequence, structure, receptor binding domains and internal repeats of human apolipoprotein B-100. Nature 323:738–740

    Article  PubMed  CAS  Google Scholar 

  • Zielinski CC, Stuller I, Müller C (1988) Increased serum concentrations of cholesterol and triglycerides in the progression of breast cancer. J Cancer Res Clin Oncol 114:514–518

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. Niendorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Beisiegel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Pathologie, Universität Hamburg, Martinistraße 52, W-2000, Hamburg 20, Federal Republic of Germany

    G. Seifert Professor Dr.

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Niendorf, A., Beisiegel, U. (1991). Low-Density Lipoprotein Receptors. In: Seifert, G. (eds) Cell Receptors. Current Topics in Pathology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75515-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75515-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75517-0

  • Online ISBN: 978-3-642-75515-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation