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Sequential Bolus Administration of rIL-2 (RU 49637) in Treatment of Advanced Solid Malignancies

  • D. Blaise
  • A. M. Stoppa
  • M. Brandelys
  • M. A. Cappiello
  • D. Olive
  • J. Gabert
  • R. Favre
  • D. Hans
  • A. P. Blanc
  • M. Resbeut
  • M. Sayag
  • J. J. Bonnerandi
  • D. Maraninchi
Conference paper

Abstract

The use of recombinant interleukin-2 (rIL-2) is under intensive investigation since promising reports have shown high activity in patients with refractory neoplasias [2]. Recombinant technology permits the development of different recombinant molecules, the activity of which are difficult to compare. Biological tests are insufficient at the present time to give adequate comparison of clinical activity of these molecules. It was necessary to conduct clinical trials to determine the maximum tolerable dose (MTD) which can be administrated to patients with a reasonable toxicity as efficacity is related to the maximum exposure to RIL-2. Most of the reported trials used combinations of rIL-2 and cellulotherapy for diseases previously shown to be sensitive to immunotherapy [3, 4]. New strategies using different administration schedules or cytokine combinations without stimulation of cells in vitro may be a lighter and more efficient approach. In this phase 1 trial we determined MTD of RU 49637 by sequential delivery over 34 days.

Keywords

Maximum Tolerable Dose Lymphokine Activate Killer Adequate Comparison Cytokine Combination Cardiac Stress Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • D. Blaise
  • A. M. Stoppa
  • M. Brandelys
  • M. A. Cappiello
  • D. Olive
  • J. Gabert
  • R. Favre
  • D. Hans
  • A. P. Blanc
  • M. Resbeut
  • M. Sayag
  • J. J. Bonnerandi
  • D. Maraninchi

There are no affiliations available

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