Abstract
Lymphotoxin (LT) is a cytokine primarily produced by lymphocytes [1]. It is cytostatic or cytotoxic for certain tumor cells in vitro and in vivo. Some cancer cells are particularly sensitive to the cytostatic activity of TNF-α and LT, whereas other cells are insensitive. Combination of TNF-α and interferons (IFNs), particularly IFN-γ, markedly increases the sensitivity in some previously nonresponsive cell lines [2–4]. We investigated the effect of recombinant (r)LT in combination with rIFN-α, hIFN-ß, and rIFN-γ on the proliferation of the breast cancer cell line MCF-7.
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References
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© 1990 Springer-Verlag, Berlin Heidelberg
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Buck, C. et al. (1990). Synergism of Lymphotoxin and Interferon-γ in the Growth Inhibition of Breast Cancer Cell Line MCF-7. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_28
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DOI: https://doi.org/10.1007/978-3-642-75510-1_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52281-2
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