Abstract
Granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin 3 (IL-3) are naturally occurring glycoproteins involved in the regulation of the proliferation and differentiation of haematopoietic progenitor cells [1–3]. Besides their activity on immature myeloid cells, effects of GM-CSF on mature neutrophils, monocytes and eosinophils have been described [4–7]. Based on these in vitro data GM-CSF has been tested in clinical phase I and II trials with encouraging results in patients suffering from myelodysplastic syndromes, acquired immunodeficiency syndrome (AIDS) and cancer after myelosuppressive chemotherapy and/or bone marrow transplantation [8–11]. IL-3, which seems to act as a “multipoietin” stimulating all three haematopoietic cell lines, is now being tested in clinical phase I trials.
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Nachbaur, D., Denz, H., Zwierzina, H., Schmalzl, F., Huber, H. (1990). Stimulation of Colony Formation of Various Human Carcinoma Cell Lines by rhGM-CSF and rhIL-3. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_25
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DOI: https://doi.org/10.1007/978-3-642-75510-1_25
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