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Chemiluminescence of Polymorphonuclear Leukocytes in Response to Interferons

  • Conference paper
Cytokines in Hemopoiesis, Oncology, and AIDS

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Abstract

Interest in the pleiotropic action of IFNs has focussed on their antiviral, antimitogenic and immunomodulatory activities [45, 47]. As IFNs express activity against several human malignancys, new possibilities for managing patients with cancer have been suggested and are under investigation [11, 20, 35, 36, 44]. Evidence was given that type I (leukocyte and fibroblast) and type II (γ) IFNs operate through independent receptor sites [5, 50] and induce alterations in cell membranes and in the cytoskelton [41, 33]. IFN-γ has been found in various systems to display greater antiproliferative effects and inhibition of CFU-GM than either IFN-α or IFN-β [4, 6, 12, 29].

Supported by Deutsche Forschungsgemeinschaft Ri 257/7-1

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Authors
  1. M. Suttorp
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  2. U. Barzantny
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  3. M. Rister
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Editors and Affiliations

  1. Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Mathias Freund  & Hartmut Link  & 

  2. Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Karl Welte

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© 1990 Springer-Verlag, Berlin Heidelberg

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Suttorp, M., Barzantny, U., Rister, M. (1990). Chemiluminescence of Polymorphonuclear Leukocytes in Response to Interferons. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-75510-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

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