Abstract
One of the most striking features of the HLA gene products is their high degree of polymorphism. The HLA class II polymorphism varies from locus to locus, e.g. at present there are 18 serological defined antigens at the DR locus and only half that number at the DQ locus (Bodmer et al. 1989). Within a polymorphic gene certain exons are more polymorphic than others, e.g.the gene segments encoding the first domains of DRB, DQA and DQB chains contain most of the sequence variation. Furthermore, even within the first domain, the polymorphism is concentrated in areas called allelic hypervariable regions (Bell et al. 1987). Various mechanisms have been implicated as being responsible for the generation of HLA polymorphism such as homologous and non-homologous crossing-over, point mutation and gene conversion.
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References
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© 1990 Springer-Verlag Berlin Heidelberg
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Oudshoorn, M., du Toit, E.D., Martell, R.W. (1990). The Generation of Class II Polymorphism by Recombination. In: Polesky, H.F., Mayr, W.R. (eds) 13th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.) New Orleans, October 19–21, 1989. Advances in Forensic Haemogenetics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75496-8_61
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DOI: https://doi.org/10.1007/978-3-642-75496-8_61
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