Abstract
We have developed a polymerase chain reaction (PCR) system for typing group specific component (Gc). Our Gc DNA typing system has several advantages:
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1.
The 2, 1F and 1S Gc alleles can be typed unambiguously.
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2.
An individual’s Gc type can be obtained from any biological sample from which DNA can be isolated and amplified (e.g. blood, hair, semen, saliva, bone).
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3.
The Gc typing can be combined with other genetic marker systems typed by DNA analysis (e.g. HLA DQα) to give a very high power of discrimination.
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References
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Yang F, Brune J. L, Naylor S. L, Cupples R. L, Naberhaus K. H, Bowman, B. H, (1985) Human group-specific component (Gc) is a member of the albumin family. Proc. Natl. Acad. Sci. USA 82:7994–7998
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© 1990 Springer-Verlag Berlin Heidelberg
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Reynolds, R.L., Sensabaugh, G.F. (1990). Use of the Polymerase Chain Reaction for Typing Gc Variants. In: Polesky, H.F., Mayr, W.R. (eds) 13th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.) New Orleans, October 19–21, 1989. Advances in Forensic Haemogenetics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75496-8_47
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DOI: https://doi.org/10.1007/978-3-642-75496-8_47
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52271-3
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