Amorolfine (3-[p-(1,1-dimethylpropyl)-phenyl]2-methyl-propyl-2,6-cis dimethylmorpholine hydrochloride; Ro 14-4767/002) shows activity against fungi pathogenic to plants, animals and humans (Polak and Dixon 1987). Given here is a resume of preclinical findings with this drug as well as a summary of published clinical data. In vitro the spectrum against representative species pathogenic for humans was defined measuring fungistatic as well as fungicidal effects. In vivo studies were conducted using models of dermatophytosis, vaginal candidosis and various organ mycoses.
KeywordsAspergillus Candida Fusarium Azole Itraconazole
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