Abstract
The process of applying or administering a drug to humans, either healthy volunteers or patients, under careful observation by research physicians and directed at answering questions about the drug, is referred to as the conduct of clinical trials. Although most people would agree with this definition, one must predict that few other statements regarding aspects of clinical trials would result in uniformity of opinion. Indeed, if one were to place a value judgement on the conduct of clinical trials, such as whether they are good, or important, or necessary, or scientifically based, or unethical, vigorous disagreements would immediately emerge. Therefore, in this chapter we will only touch on a few aspects of clinical trials relevant to the study of antifungal drugs. For a general review of clinical trials numerous other texts should be consulted (e.g., Burley and Glynne 1985; Spriet and Simon 1985; World Health Organization 1975; Cioms 1983). We have attempted to place this presentation in perspective by discussing briefly in the first section why clinical trials are used in the development of new antifungal drugs.
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Jones, T.C., Stern, J.J. (1990). Clinical Trials. In: Ryley, J.F. (eds) Chemotherapy of Fungal Diseases. Handbook of Experimental Pharmacology, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75458-6_14
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DOI: https://doi.org/10.1007/978-3-642-75458-6_14
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