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Relationship Between Class II Structure and B Cell Signaling

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Transgenic Mice and Mutants in MHC Research

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Abstract

The B cell clone CH12.LX can be induced to differentiate to Ig secretion in the presence of antigen (sheep red blood cells, SRBC) and T cells or monoclonal antibodies (Mabs) specific for the Ek molecules of CH12.LX (1). The Ak molecules of CH12.LX do not serve this function of B cell signal transmission, although CH12.LX Ak shows no mutations in protein sequence (2), and functions normally in antigen presentation and Mab binding (1,2). To determine if A molecules of other haplotypes could overcome this failure of Ak-mediated signaling, CH12.LX cells were transfected with genes encoding new Aα and/or Aß molecules. Results of these experiments suggest portions of the Aß molecule which are important to the function of B cell signaling.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599-7290, USA

    J. A. Frelinger

Authors
  1. G. A. Bishop
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  2. J. A. Frelinger
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Editor information

Editors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, ME, 04609, USA

    Igor K. Egorov Ph.D., D.Sci.

  2. Department of Immunology, Mayo Medical School, Mayo Clinic, Rochester, MN, 55905, USA

    Chella S. David Ph.D.

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© 1990 Springer-Verlag Berlin Heidelberg

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Bishop, G.A., Frelinger, J.A. (1990). Relationship Between Class II Structure and B Cell Signaling. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-75442-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75444-9

  • Online ISBN: 978-3-642-75442-5

  • eBook Packages: Springer Book Archive

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