Abstract
MHC (Major Histocompatibility Complex) Class II antigens are polymorphic cell surface glycoproteins which bind foreign antigens and form a complex which is recognized by T lymphocyte antigen receptors. Presentation of foreign antigens by self MHC molecules to T cells triggers antigen-specific responses in the immune system. Thus, increasing the expression of MHC class II molecules on the surface of antigen-presenting cells contributes to the initiation and amplification of immune responses.
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References
Basta, P.V., Sherman, P.A. and Ting, J.P.-Y. (1988). Detailed delineation of an interferon-γ-responsive element important in human HLA-DRα gene expression in a glioblastoma multiform line. Proc. Natl. Acad. Sci. USA 85, 8618–8622.
Boss, J.M. and Strominger, J.L. (1986). Regulation of a transfected human class II MHC gene in human fibroblasts. Proc. Natl. Acad. Sci. USA 83, 9139–9143.
Boothby, M., Gravallese, E., Liou, H.-C. and Glimcher, L.H. (1988). A DNA binding protein regulated by IL-4 and by differentiation in B cells. Science 242, 1559–1562.
Boothby, M., Liou, H.-C. and Glimcher, L.H. (1989). Differences in DNA sequence specificity among MHC class II X box binding proteins. J. Immunol. 142, 1005–1014.
Chodosh, L.A., Olesen, J., Hahn, S., Baldwin, A.S., Guarente, L. and Sharp, P.A. (1988). A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53, 25–35.
Dorn, A., Bollekens, J., Staub, A., Benoist, C. and Mathis, D. (1987a). A multiplicity of CCAAT box-binding proteins. Cell 50, 863–872.
Dorn, A., Durand, B., Marfing, C., LeMeur, M., Benoist, C. and Mathis, D. (1987b). Conserved MHC class II boxes-X and Y are transcriptional control elements and specifically bind nuclera proteins. Proc. Natl. Acad. Sci. USA 84, 6249–6255.
Gonzalez, G.A., Yamamato, K.K., Fisher, W.H., Karr, D., Menzel, P., Biggs, W., Vale, W.W. and Montminy, M.R. (1989). A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 337, 749–752.
Hoeffler, J.P., Meyer, T.E., Yun, Y., Jameson, J.I. and Habener, J.F. (1988). Cyclic AMP-responsive DNA binding protein: Structure based on a cloned placental cDNA. Science 242, 1430–1433.
Lin, Y.-S. and Green, M.R. (1988). Interaction of a common cellular transcription factor, ATF, with regulatory elements in both Ela and cyclic-AMP inducible promoters. Proc. Natl. Acad. Sci. USA 85, 3396–3400.
Liou, H.-C., Polla, B.S., Aragnol, D., Leserman, L.D., Griffith, I.J. and Glimcher, L.H. (1988a). A tissue specific DNase I hypersensitive site in a class II Aα gene is under trans-regulatory control. Proc. Natl. Acad. Sci. USA 85, 2738–2742.
Liou, H.-C., Boothby, M.R. and Glimcher, L.H. (1988b). Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. Science 242, 69–71.
Singh, H., LeBowitz, J.H., Baldwin, A.S. and Sharp, P.A. (1988). Molecular cloning of an enhancer binding protein: Isolation by screening of an expression library with a recognition site DNA. Cell 52, 415–423.
Struhl, K. (1988). The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Nature 332, 649–650.
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© 1990 Springer-Verlag Berlin Heidelberg
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Liou, HC., Ivashkiv, L.B., Kara, C.J., Glimcher, L.H. (1990). Transcriptional Regulation of MHC Class II Gene Expression: Are MHC Class II Genes Coordinately Regulated?. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_19
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DOI: https://doi.org/10.1007/978-3-642-75442-5_19
Publisher Name: Springer, Berlin, Heidelberg
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