Abstract
Transgenic mice have proven to be useful for the study of many different biological phenomenon, such as gene regulation, oncogenesis, and immunological function. The expression of novel gene products in transgenic mice, such as the major histocompatibility antigens, has allowed investigators to more easily study the role of these antigens in tissue transplantation and rejection, in organ development and tumorigenesis. A useful vector for use in such studies would be one that is capable of directing expression of a variety of gene products to specific cell types in different tissues. We have been studying the tissue-specific expression of the mouse mammary tumor virus (MMTV), with the goal of developing such vectors.
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References
Choi Y, Henrard D, Lee I, Ross SR (1987) The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J Virol 61: 3013–3019
Choi Y, Lee I, Ross SR (1988) Requirement for the Simian Virus 40 small tumor antigen in tumorigenesis in transgenic mice. Mol and Cell Biol 8: 3382–3390
Henrard D and Ross SR (1988) Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland. J Virol 62: 3046–3049
Leder A, Pattengale PK, Kuo A, Stewart TA, Leder P (1986) Consequence of widespread deregulation of c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 45: 485–495
Ross SR and Solter D (1985) Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice. Proc Natl Acad Sci USA 82: 5880–5994
Tegtmeyer P (1980) Molecular biology of tumor viruses, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, p. 297.
Yamamoto KR (1985) Steroid receptor regulated transcription of specific genes and gene networks. Ann Rev Genet 19: 209–252.
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© 1990 Springer-Verlag Berlin Heidelberg
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Ross, S.R., Choi, Y., Hsu, CL.L., Dudley, J. (1990). Mouse Mammary Tumor Virus-Directed Gene Expression in Transgenic Mice. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_14
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DOI: https://doi.org/10.1007/978-3-642-75442-5_14
Publisher Name: Springer, Berlin, Heidelberg
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