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Algorithms for Use in Purity Control of Drugs Using UV-Spectroscopy

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Software Development in Chemistry 4

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Abstract

UV-spectroscopy is a nonspecific analytical method, but in contrast to this it is possible to develop methods for purity control of drugs using this type of spectroscopy. Two algorithms will be described in this paper: a differential method subtracting the spectra of the analysis and a reference followed by nonparametric tests and the rank of a matrix containing both spectra. Base of both methods is a sophisticated comparison of both spectra. With two examples will be confirmed the proposed method. In some cases it is possible to detect impurities below 0.1%.

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References

  1. Windmann S (1990) Ph D Thesis, Würzburg

    Google Scholar 

  2. Mück W (1987) Datenauswertung in der HPLC-UV-VIS-Kopplung. Ph D Thesis, Würzburg

    Google Scholar 

  3. Ebel S, Mück W (1988) Fresenius Z Anal Chem 331:359

    Article  CAS  Google Scholar 

  4. Kang JS (1990) Beiträge zur Analytik von Antibiotika mit Hilfe der Dünnschichtchromatographie. Ph D Thesis, Würzburg

    Google Scholar 

  5. Weitkamp H, Wortig D (1977) Mikrochim Acta II:315

    Article  Google Scholar 

  6. Sachs L (1978) Angewandte Statistik. Springer Verlag, Berlin

    Google Scholar 

  7. McCornack RL (1965) J Amer Assoc 60:864

    Article  Google Scholar 

  8. Dixon WJ, Mood AM (1946) J Amer Statist Assoc 41:557–566

    Article  CAS  Google Scholar 

  9. Lipschutz S (1986) Lineare Algebra, McGraw-Hill Book Company, Hamburg — New York

    Google Scholar 

  10. Mellinger M (1987) Chemom Intell Laborat Systems 2:29–36

    Article  Google Scholar 

  11. Wold S, Esbensen K, Geladi P (1987) Chemom Intell Laborat Systems 2:37–52

    Article  CAS  Google Scholar 

  12. Shrager RI, Hendler RW (1982) Anal Chem 54:1147–1152

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, D-8700, Würzburg, Germany

    S. Ebel, C. Urban & S. Windmann

Authors
  1. S. Ebel
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  2. C. Urban
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  3. S. Windmann
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Editor information

Editors and Affiliations

  1. Institute of Organic Chemistry, Technical University of Munich, Lichtenbergstraße 4, D-8046, Garching, Germany

    Johann Gasteiger

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© 1990 Springer-Verlag Berlin Heidelberg

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Ebel, S., Urban, C., Windmann, S. (1990). Algorithms for Use in Purity Control of Drugs Using UV-Spectroscopy. In: Gasteiger, J. (eds) Software Development in Chemistry 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75430-2_24

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  • DOI: https://doi.org/10.1007/978-3-642-75430-2_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52173-0

  • Online ISBN: 978-3-642-75430-2

  • eBook Packages: Springer Book Archive

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