Clinical research in the field of pediatric oncology has been carried out in the Federal Republic of Germany in the form of multicenter cooperative therapy studies since the early 1970s . One of the first studies, which investigated the treatment of acute lymphoblastic leukemia (ALL), was started by Lampert in 1971 for the Deutsche Arbeitsgemeinschaft für Leukamieforschung und -behandlung im Kindesalter (German Study Group for Research and Treatment of Leukemia in Childhood). For the first time, a high degree of uniformity in treatment was thus achieved in this country . At the same time, Riehm developed a remarkably effective therapy concept for ALL. It consisted of an eight-week combined induction/consolidation phase with eight different cytotoxic agents and irradiation of the central nervous system as well as subsequent maintenance therapy [139, 140]. The same concept was adopted by the first cooperative acute myelogenous leukemia (AML) study BFM-78.
KeywordsLeukemia Corticosteroid Folic Acid Glucocorticoid Cyclophosphamide
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