How to Position Exocrine and Endocrine Function Tests in the Diagnostic Approach to Chronic Pancreatitis
Patients with chronic impairment of pancreatic exocrine function usually present with abdominal pain or with diarrhea, steatorrhea, and weight loss. Those patients who have abdominal pain as their chief complaint may develop diarrhea, steatorrhea, and weight loss or may always have abdominal pain as their major symptom and never evolve to frank exocrine insufficiency. Approximately 15% of patients with chronic pancreatitis never manifest abdominal pain and present initially with diarrhea, steatorrhea, and weight loss.
KeywordsChronic Pancreatitis Pancreatic Polypeptide Exocrine Function Pancreatic Exocrine Function Pancreatic Exocrine Insufficiency
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Toskes P (1983) Bentiromide as a test of exocrine pancreatic function in adult patients with pancreatic exocrine insufficiency: determination of appropriate dose and urinary collection period. Gastroenterology 85:565–569PubMedGoogle Scholar
Meyer B, Campbell D, Curington C, Toskes P (1987) The bentiromide test is not affected in patients with small bowel disease of liver disease. Pancreas 2:44–47PubMedCrossRefGoogle Scholar
Jacobson D, Curington C, Connery K, Toskes P (1984) Trypsin-like immunoreactivity as a test for pancreatic insufficiency. N Engl J Med 310:1307–1309PubMedCrossRefGoogle Scholar
Campbell D, Slaff J, McGuigan J, DesJardin L, Toskes P (1985) Integrated pancreatic polypeptide response in pancreatic diseases. Gastroenterology 88:1341Google Scholar
Domschke S, Heptner G, Kolb S, Sailer D, Schneider MU, Domschke W (1986) Decrease in plasma amino acid level after secretin and pancreozymin as an indicator of exocrine pancreatic function. Gastroenterology 90:1031–1038PubMedGoogle Scholar
Heptner G, Domschke S, Domschke W (1989) Exocrine pancreatic function after gastrectomy. Specificity of indirect tests. Gastroenterology 97:147–153PubMedGoogle Scholar
Gullo L, Pezzilli R, Ventrucci M (1989) Cerulein-induced plasma amino acid decrease: a simple, sensitive, and specific test of pancreatic function. Pancreas 4:619CrossRefGoogle Scholar
Keller U, Szollosy E, Varga L, Gyr K (1984) Pancreatic glucagon secretin and exocrine function (BT-PABA test) in chronic pancreatitis. Dig Dis Sci 29:853–857PubMedCrossRefGoogle Scholar
Toskes P, Greenberger N (1983) Acute and chronic pancreatitis. Disease-a-Month 29:1–81PubMedCrossRefGoogle Scholar
© Springer-Verlag Berlin Heidelberg 1990