Feedback Mechanisms in the Control of Exocrine Pancreatic Function

  • Ch. Owyang
Conference paper


Recent physiological studies indicate that both cholecystokinin (CCK) and the cholinergic enteropancreatic reflexes are important to stimulate pancreatic enzyme secretion. Little is known, however, about regulating these pathways. In this study we investigated the mechanisms responsible for feedback modulation of CCK release and the enteropancreatic reflexes.


Pancreatic Secretion Pancreatic Polypeptide Exocrine Pancreatic Function Amylase Release Amylase Output 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Booth AND, Robbins WE, Ribelin WE, DeEds F (1960) Effect of raw soybean meal and amino acids on pancreatic hypertrophy in rats. Proc Soc Exp Biol Med 104:681–683Google Scholar
  2. 2.
    Lyman RL (1957) The effect of raw soybean meal and trypsin inhibitor diets on the intestinal and pancreatic nitrogen in the rat. J Nutr 62:285–294PubMedGoogle Scholar
  3. 3.
    Lyman RL, Lepkovsky S (1957) The effect of raw soybean meal and trypsin inhibitor diets on pancreatic enzyme secretion in rat. J Nutr 62:265–284Google Scholar
  4. 4.
    Green GM, Lyman RL (1972) Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor-induced hypersecretion in rats. Proc Soc Exp Biol Med 140:6–12PubMedGoogle Scholar
  5. 5.
    Chernick SS, Lepkovsky S, Chaikoff IL (1948) A dietary factor regulating the enzyme content of the pancreas: changes induced in size and proteolytic activity of the chick pancreas by ingestion of raw soybean meal. Am J Physiol 155:33–41PubMedGoogle Scholar
  6. 6.
    Corring T (1973) Mechanisme de la secrétion pancréatique exocrine chez le porc: regulation par rétro inhibition. Ann Biol Anim Biochim Biophys 13:755–756CrossRefGoogle Scholar
  7. 7.
    Slaff J, Jacobson D, Tillman CR, Curington C, Toskes P (1984) Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 87:44–52PubMedGoogle Scholar
  8. 8.
    Owyang C, Louie DS, Tatum D (1986) Feedback regulation of pancreatic enzyme secretion. J Clin Invest 77:2042–2047PubMedCrossRefGoogle Scholar
  9. 9.
    Owyang C, May D, Louie DS (1986) Trypsin suppression of pancreatic enzyme secretion. Gastroenterology 91:637–647PubMedGoogle Scholar
  10. 10.
    Dlugosz J, Fölsch UR, Creutzfeldt W (1983) Inhibition of intraduodenal trypsin does not stimulate exocrine pancreatic secretion in man. Digestion 26:197–204PubMedCrossRefGoogle Scholar
  11. 11.
    Hotz J, Ho SB, Go VLW, DiMagno E (1983) Short term inhibition of duodenal trypsin activity does not affect human pancreatic biliary or gastric function. J Lab Clin Med 101:488–495PubMedGoogle Scholar
  12. 12.
    Alder G, Mullenhoff A, Bozkurt T, Koop I, Göke B, Arnold R (1986) Effect of protease inhibitor (FOY 305) on pancreatic secretion and plasma CCK in human. Digestion 35:3Google Scholar
  13. 13.
    Liener IR, Goodale RL, Desmukh A, Satterberg TL, Ward G, DiPietro CM, Bankey PE, Borner JW (1988) Effect of trypsin inhibitor from soybeans (Bowman-Birk) on the secretory activity of the human pancreas. Gastroenterology 94:419–427PubMedGoogle Scholar
  14. 14.
    Khayambashi H, Lyman RL (1969) Secretion of rat pancreas perfused with plasma from rats fed soybean trypsin inhibitor. Am J Physiol 217:646–651PubMedGoogle Scholar
  15. 15.
    Ihse I (1976) Abolishment of oral trypsin inhibitor stimulation of the rat exocrine pancreas after duodenal resection. Scand J Gastroenterol 11:11–15PubMedGoogle Scholar
  16. 16.
    Louie DS, May D, Miller P, Owyang C (1986) Cholecystokonin mediates feedback regulation of pancreatic enzyme secretion in rats. Am J Physiol 250:G252–259PubMedGoogle Scholar
  17. 17.
    Louie DS, Liang JP, Owyang C (1988) Characterization of a new CCK antagonist L346,718: in vitro and in vivo studies. Am J Physiol 255:G261–G266PubMedGoogle Scholar
  18. 18.
    Lu L, Louie DS, Owyang C (1989) A cholecystokinin releasing peptide mediates feedback regulation of pancreatic secretion. Am J Physiol 256:G430–G435PubMedGoogle Scholar
  19. 19.
    Valenzuela JE, Lamers CB, Modlin IM, Walsh JH (1983) Cholinergic component in the human pancreatic secretory response to intraintestinal oleate. Gut 24:807–811PubMedCrossRefGoogle Scholar
  20. 20.
    Dooley CP, Valenzuela JE (1984) Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion. Gastroenterology 86:23–27PubMedGoogle Scholar
  21. 21.
    Schwartz TW (1983) Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 85:1411–1425PubMedGoogle Scholar
  22. 22.
    Larsson LI, Sundler F, Hakanson R (1976) Pancreatic polypeptide a postulated hormone: identification of its cellular storage site by light and electron-microscopic immunocytochemistry. Diabetologia 12:211–216PubMedCrossRefGoogle Scholar
  23. 23.
    Schwartz TW, Rehfeld JF, Stadil F, Larsson LI, Chance RE, Moon M (1976) Pancreatic polypeptide response to food in duodenal ulcer patients before and after vagotomy. Lancet 1:1102–1105PubMedCrossRefGoogle Scholar
  24. 24.
    Taylor IL, Impicciatore M, Walsh JH (1978) Effect of atropine and vagotomy on the pancreatic polypeptide response to a meal. Am J Physiol 235:E443–447PubMedGoogle Scholar
  25. 25.
    Greenberg GR, McCloy RF, Adrian TE, Chadwick VS, Baron JH, Bloom SR (1978) Inhibition of pancreas and gallbladder by pancreatic polypeptide. Lancet 2:1280–1282PubMedCrossRefGoogle Scholar
  26. 26.
    Taylor IL, Solomon T, Walsh J, Grossman M (1979) Pancreatic polypeptide: metabolism and effect on pancreatic secretion in dogs. Gastroenterology 76:524–528PubMedGoogle Scholar
  27. 27.
    Greenberg GR, McCloy RF, Chadwick VS, Adrian TE, Baron JH, Bloom SR (1979) Effect of bovine pancreatic polypeptide on basal pancreatic and biliary outputs in man. Am J Dig Dis 24:11–14CrossRefGoogle Scholar
  28. 28.
    Adrian TE, Bloom SR, Hermansen K, Iversen J (1978) Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas, Diabetologia 14:413–417PubMedCrossRefGoogle Scholar
  29. 29.
    Hermansen K, Schwartz TW (1979) The influence of calcium on the basal and acetylcholinestimulated secretion of pancreatic polypeptide. Endocrinology 105:1409–1474CrossRefGoogle Scholar
  30. 30.
    Schwartz TW, Holst JJ, Fahrenkrug J, Jensen SL, Nielsen OV, Rehfeld JF, Schaffalitzkg DE, Muckadell OB, Stadil F (1978) Cholinergic vagal regulation of pancreatic polypeptide secretion. J Clin Invest 61:781–789PubMedCrossRefGoogle Scholar
  31. 31.
    Guzman S, Lonovics J, Devitt PG, Heijtmancik KE, Rayford PL, Thompson JC (1981) Hormone-stimulated release of pancreatic polypeptide before and after vagotomy in dogs. Am J Physiol 240:G114–121PubMedGoogle Scholar
  32. 32.
    Adrian TE, Bloom SR, Besterman HS (1977) Mechanism of pancreatic polypeptide release in man. Lancet 1:161–163PubMedCrossRefGoogle Scholar
  33. 33.
    Taylor IL, Walsh JH, Carter D, Wood J, Grossman MI (1979) Effect of atropine and bethanechol on bombesin-stimulated release of pancreatic polypeptide and gastrin in dog. Gastroenterology 77:714–718PubMedGoogle Scholar
  34. 34.
    Blackborn AM, Fletcher DR, Adrian TE, Bloom SR (1980) Neurotensin infusions in man: pharmacokinetics and effect on gastrointestinal and pituitary hormones. J Clin Endocrinol Metab 51:1257–1261CrossRefGoogle Scholar
  35. 35.
    Adrian TE, Besterman HS, Bloom SR (1979) The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man. Life Sci 24:1989–1994PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Ch. Owyang
    • 1
  1. 1.Department of Internal Medicine, Division of GastroenterologyThe University of Michigan Medical CenterAnn ArborUSA

Personalised recommendations