A Fresh Look at Autoantibodies in Chronic Pancreatitis

  • W. A. Scherbaum
  • A. Fetzer
  • H. Friess
  • P. Malfertheiner
  • M. Büchler
Conference paper


Several lines of evidence suggest that autoimmune phenomena may underlie a subgroup of cases with chronic pancreatitis (CP). In particular, autoantibodies (AB) to pancreatic acinar cells and ductal antigens have been described [7, 8, 11, 20], and lymphocytes specifically sensitized to crude pancreatic antigens have been detected in patients with CP [15, 21]. Lymphocytic infiltrates with activated cells can be detected in the exocrine pancreas, and besides hyperexpression of HLA class I molecules, aberrant expression of HLA-DR molecules on exocrine pancreatic cells has been described in CP [3, 6].


Chronic Pancreatitis Acinar Cell Pancreatic Acinar Cell Exocrine Pancreas Cell Antibody 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • W. A. Scherbaum
    • 1
  • A. Fetzer
    • 1
  • H. Friess
    • 2
  • P. Malfertheiner
    • 3
  • M. Büchler
    • 2
  1. 1.Department of General Medicine IUniversity of UlmUlmGermany
  2. 2.Department of SurgeryUniversity of UlmUlmGermany
  3. 3.Department of General Medicine IIUniversity of UlmUlmGermany

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