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A Fresh Look at Autoantibodies in Chronic Pancreatitis

  • W. A. Scherbaum
  • A. Fetzer
  • H. Friess
  • P. Malfertheiner
  • M. Büchler
Conference paper

Abstract

Several lines of evidence suggest that autoimmune phenomena may underlie a subgroup of cases with chronic pancreatitis (CP). In particular, autoantibodies (AB) to pancreatic acinar cells and ductal antigens have been described [7, 8, 11, 20], and lymphocytes specifically sensitized to crude pancreatic antigens have been detected in patients with CP [15, 21]. Lymphocytic infiltrates with activated cells can be detected in the exocrine pancreas, and besides hyperexpression of HLA class I molecules, aberrant expression of HLA-DR molecules on exocrine pancreatic cells has been described in CP [3, 6].

Keywords

Chronic Pancreatitis Acinar Cell Pancreatic Acinar Cell Exocrine Pancreas Cell Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Becker V, Stolte M (1976) Klinische Pathologie des Pankreas. Med Welt 27:901PubMedGoogle Scholar
  2. 2.
    Bottazzo GF, Pujol-Borrell R, Gale EAM (1986) Autoimmunity in diabetes: progress, consolidation and controversy. In: Alberti KGMM, Krall LP (eds) The diabetes annual/2. Elsevier, Amsterdam, pp 13–29Google Scholar
  3. 3.
    Bovo P, Mirakian R, Merigo F, Angelini G, Cavallini G, Rizzini P, Bottazzo GF, Scura LA (1987) HLA molecule expression on chronic pancreatitis specimens: is there a role for autoimmunity? A preliminary study. Pancreas 2:350–356PubMedCrossRefGoogle Scholar
  4. 4.
    Büchler M, Bockman D, Bittner R, Beger HG (1988) Ultrastruktur der Nerven im menschlichen Pankreas: morphologische Belege zur Schmerzpathogenese bei chronischer Pankreatitis. Lang Arch Chir (Chirurgisches Forum) 187–192Google Scholar
  5. 5.
    Colman PG, Roberts-Thomson JC, Begley CG, Harrison LC, Tait BD (1987) Evidence against an immunogenetic basis for diabetes in chronic pancreatitis. Aust NZ J Med 17:392–395CrossRefGoogle Scholar
  6. 6.
    Foulis AK, Farquharson MA, Hardman R (1987) Aberrant expression of class I major histocompatibility complex molecules by B cells and hyperexpression of class II major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30:333–343PubMedCrossRefGoogle Scholar
  7. 7.
    Lankisch PG, Koop H, Seelig R, Seelig HP (1981) Antinuclear and pancreatic acinar cell antibodies in pancreatic diseases. Digestion 21:65–68PubMedCrossRefGoogle Scholar
  8. 8.
    Lendrum R, Walker G (1975) Serum antibodies in human pancreatic disease. Gut 16:365–371PubMedCrossRefGoogle Scholar
  9. 9.
    Logtenberg T, Melissen PMB, Kroon A, Gmelig-Meyling FHJ, Ballieux RE (1988) Autoreactive B cells in normal humans. Autoantibody production upon lymphocyte stimulation with autoantigen-xenoantigen conjugates. J Immunol 140:446–450PubMedGoogle Scholar
  10. 10.
    Richter W, Eiermann TH, Graf G, Glück M, Scherbaum WA, Pfeiffer EF (1989) Isolation of IgG islet cell antibody-producing B lymphocytes from the peripheral blood of type 1 diabetic patients and an ICA-positive non-diabetic individual. Horm Metab Res 21:686–688PubMedCrossRefGoogle Scholar
  11. 11.
    Rumessen JJ, Marner B, Thorsgaard Pedersen N, Permin H (1985) Autoantibodies in chronic pancreatitis. Scand J Gastroenterol 20:966–970PubMedCrossRefGoogle Scholar
  12. 12.
    Scherbaum WA, Berg PA (1982) Development of adrenocortical failure in non-addisonian patients with antibodies to adrenal cortex. A clinical follow-up study. Clin Endocrinol 16:345–352CrossRefGoogle Scholar
  13. 13.
    Scherbaum WA, Bottazzo GF (1983) Autoantibodies to vasopressin cells in idiopathic diabetes insipidus. Evidence for an autoimmune variant. Lancet 1:897–901PubMedCrossRefGoogle Scholar
  14. 14.
    Scherbaum WA, Mirakian R, Pujol-Borrell R, Dean BM, Bottazzo GF (1986) Immunochemistry in the study and diagnosis of organ-specific autoimmune diseases. In: Polak JM, Van Noorden S (eds) Immunocytochemistry. Modern methods and applications. Wright, Bristol, pp 456–476Google Scholar
  15. 15.
    Schütt C, Friemel H, Schulze HA, Zubaidi G (1975) Specific lymphocyte sensitization in chronic pancreatitis. Digestion 13:308–311PubMedCrossRefGoogle Scholar
  16. 16.
    Scuro LA, Bovo P, Sandrini T, Angelini G, Cavallini G, Mirakian R (1983) Autoimmunity and diabetes associated with chronic pancreatitis. Lancet 1:424 (Letter)Google Scholar
  17. 17.
    Stutchfield PR, O’Halloran SM, Smith CS, Woodrow JC, Bottazzo GF, Heaf D (1988) HLA type, islet cell antibodies, and glucose intolerance in cystic fibrosis. Arch Dis Child 63:1234–1239PubMedCrossRefGoogle Scholar
  18. 18.
    Tao T-W, Leu S-L, Kriss JP (1985) Peripheral blood lymphocytes from normal individuals can be induced to secrete immunoglobulin G antibodies against self-antigen thyroglobulin in vitro. J Clin Endocrinol Metab 60:279–282PubMedCrossRefGoogle Scholar
  19. 19.
    Tarn AC, Thomas JM, Dean BM, Ingram D, Schwarz G, Bottazzo GF, Gale EAM (1988) Predicting insulin-dependent diabetes. Lancet 1:845–850PubMedCrossRefGoogle Scholar
  20. 20.
    Thal AP, Murray MJ, Egner W (1959) Isoantibody formation in chronic pancreatic disease. Lancet 1:1128–1129PubMedCrossRefGoogle Scholar
  21. 21.
    Velbri S, Nutt H (1973) Über die Rolle immunologischer Mechanismen bei Pankreaserkrankungen. Z Inn Med 28:222–227Google Scholar
  22. 22.
    Vialettes B, Lassmann V, Vague P (1983) Autoimmunity, diabetes, and chronic pancreatitis. Lancet 1:879 (Letter)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • W. A. Scherbaum
    • 1
  • A. Fetzer
    • 1
  • H. Friess
    • 2
  • P. Malfertheiner
    • 3
  • M. Büchler
    • 2
  1. 1.Department of General Medicine IUniversity of UlmUlmGermany
  2. 2.Department of SurgeryUniversity of UlmUlmGermany
  3. 3.Department of General Medicine IIUniversity of UlmUlmGermany

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