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Pancreatic Adaptation, Growth, and Regeneration in Experimental Chronic Pancreatitis

Conference paper

Abstract

There are several rat models of acute pancreatitis [1], but chronic pancreatitis-like lesions similar to the human disease are difficult to provoke in rats [8, 24, 25, 27, 29].

Keywords

Acute Pancreatitis Chronic Pancreatitis Acinar Cell Alcohol Administration Pancreatic Regeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adler G, Kern HF, Scheele GA (1986) Experimental models and concepts in acute pancreatitis. In: Go VLW, Gardner JD, Brooks FP, Lebenthal E, DiMagno EP, Scheele GA (eds) The exocrine pancreas. Biology, pathiobiology and diseases. Raven, New York, pp 407–421Google Scholar
  2. 2.
    Boros L, Pap Á, Varró V (1988) CCK-8 accelerates, the CCK-antagonist CR 1409 inhibits pancreatic regeneration after resection in rat (A-11). Digestion 40:71Google Scholar
  3. 3.
    Bussenot J, Balas D, Senegas-Balas F, Bertrand C, Ribet A (1987) Premières perturbations cellulaires lors d’une pancréatite par hyperstimulation à la céruleine chez le rat. 3rd Reunion of the Club Francais du Pancreas, ParisGoogle Scholar
  4. 4.
    Cumming ICR, Wood RA, Cushieri A, McGuiness E, Wormsley KG (1983) Effect of alcohol on pancreatic regeneration in the rat. Gut 24:A-479Google Scholar
  5. 5.
    Dagorn JC, Mongeau R (1977) Different action of hormonal stimulation on the biosynthesis of three pancreatic enzymes. Biochim Biophys Acta 498:76–82PubMedGoogle Scholar
  6. 6.
    Fölsch UR, Oldendörg A, Lankisch PG, Creutzfeld W (1984) Exocrine and endocrine function in response to raw soy flour in patients with chronic pancreatitis (A-57). Digestion 30:96Google Scholar
  7. 7.
    Fölsch UR, Cantor P, Wilms HM, Schafmayer A, Becker HD, Creutzfeldt W (1987) Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats. Gastroenterology 92:449–458PubMedGoogle Scholar
  8. 8.
    Fölsch UR, Fussek M, Ebert R, Creutzfeldt W (1988) Endocrine pancreatic function during atrophy of the exocrine gland. Pancreas 3:536–542PubMedCrossRefGoogle Scholar
  9. 9.
    Lampel M, Kern HJ (1977) Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch [A] 373:97–117CrossRefGoogle Scholar
  10. 10.
    Lászik Z, Berger Z, Pap Á, Varró V (1988) Course of experimental acute pancreatitis induced by repeated serial supramaximal CCK-8 injections in rats (A-72). Digestion 40:97CrossRefGoogle Scholar
  11. 11.
    Lev MC, Fitzgerald PJ (1968) Pancreatic acinar cell regeneration. IV. Regeneration after surgical resection. Am J Pathol 53:513–535Google Scholar
  12. 12.
    McQuaid K, Wiliams J, Grendell J (1987) CCK-receptor binding affinity changes in diet-induced acute pancreatitis (Abstr). Dig Dis Sci 32:1176Google Scholar
  13. 13.
    Mundlos S, Adler G, Shaar M, Koop I, Arnold R (1986) Exocrine pancreatic function in oleic acid-induced pancreatic insufficiency in rats. Pancreas 1:29–36PubMedCrossRefGoogle Scholar
  14. 14.
    Nagy I, Pap Á, Varró V (1986) Alcohol eliminates the trophic effect of soybean trypsin inhibitor (SBTI) administration (A-95). Digestion 35:42CrossRefGoogle Scholar
  15. 15.
    Pap Á, Boros L (1989) Alcohol induced chronic pancreatitis in rats after temporary occlusion of biliopancreatic ducts with Ethibloc. Pancreas 4:249–256PubMedCrossRefGoogle Scholar
  16. 16.
    Pap Á, Berger Z, Varró V (1981) Trophic effect of cholecystokinin-octapeptide in man. A new way in the treatment of chronic pancreatitis? Digestion 21:163–168PubMedCrossRefGoogle Scholar
  17. 17.
    Pap Á, Berger Z, Varró V (1983) Beneficial effect of a soy flour diet in chronic pancreatitis. Mt Sinai J Med (N4) 50:208–212Google Scholar
  18. 18.
    Pap Á, Berger Z, Varró V (1984) Complementary effect of cholecystokinin octapeptide and soy flour treatment in chronic pancreatitis. Mt Sinai J Med (N4) 51:254–257Google Scholar
  19. 19.
    Pap Á, Nagy I, Tóth G, Varró V (1985) Alcohol diminishes the trophic effect of cholecystokinin-octapeptide (CCK-8) (A-116). Digestion 32:209–210Google Scholar
  20. 20.
    Pap Á, Flautner L, Karácsony S, Szécsény A, Varró V (1987) Recovery of pancreatic function after distal resection for chronic pancreatitis: regeneration or merely functional amelioration? Mt Sinai J Med (N4) 54:409–412Google Scholar
  21. 21.
    Pap Á, Boros L, Berger Z, Varró V (1988) Alcohol inhibits the regeneration after pancreatic resection in rats (A-98). Digestion 40:106–107Google Scholar
  22. 22.
    Pap Á, Nagy I, Takács T, Hajnal F, Varró V (1989) Mechanisms of action of alcohol administration on the trophic effect of soybean trypsin inhibitor and cholecystokinin-octapeptide in rat. Int J Pancreatol 5:263–272PubMedGoogle Scholar
  23. 23.
    Pearson KW, Scott D, Torrance B (1977) Effect of partial surgical pancreatectomy in rats. I. Pancreatic regeneration. Gastroenterology 72:469–473PubMedGoogle Scholar
  24. 24.
    Rao MS, Subbarao V, Yeldandi AV, Reddy JK (1987) Pancreatic acinar cell regeneration following cooper deficiency induced pancreatic necrosis. Int J Pancreatol 2:71–85PubMedGoogle Scholar
  25. 25.
    Sarles H, Laugier R (1981) Alcoholic pancreatitis. Clin Gastroenterol 10:401–415PubMedGoogle Scholar
  26. 26.
    Singh M (1986) Ethanol and the pancreas. In: Go VLW, Gardner JD, Brooks FP, Lebenthal E, DiMagno EP, Scheele GA (eds) The exocrine pancreas. Biology, pathobiology and diseases. Raven, New York, pp 423–442Google Scholar
  27. 27.
    Steinberg WM, Burns MK, Henry JP, Nochomovizt LE, Anderson KK (1987) Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency. Pancreas 2:176–180PubMedCrossRefGoogle Scholar
  28. 28.
    Tani S, Otsuki M, Itoh H, Fujii M, Nakamura T, Oka T, Baba S (1987) Histologic and biochemical alteration in experimental acute pancreatitis induced by supramaximal cerulein stimulation. Int J Pancreatol 2:337–348PubMedGoogle Scholar
  29. 29.
    Tomita T, Rhodes J, Falscroft J, Doull V, Kimmel JR, Polloch GG (1988) Endocrine pancreas in the rat model of exocrine pancreatic insufficiency. Pancreas 3:568–575PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. Pap
    • 1
  1. 1.First Department of MedicineAlbert Szent-Györgyi Medical UniversitySzegedHungary

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