Abstract
Chronic pancreatitis causes profound changes to occur in the makeup of the pancreas. There is functional and morphological regression of the exocrine parenchyma. Acinar cells in affected areas contain fewer or no zymogen granules; the cells decrease in height. The result of this reversion is tubular complexes, which are derived from a combination of acini and small ducts, but which have the appearance of a collection of ducts [5]. These areas are sometimes interpreted as resulting from ductular proliferation, but there is a notable paucity of mitoses. The acinar tissue disappears with time. Some of the loss comes about by a process which has been termed apoptosis because the apical part of the acinar cell is sloughed off. Some of the cells simply disintegrate and become part of the amorphous material which may be drained away by patent ducts or retained in the connective tissue space.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alvarado F (1955) Distribution of nerves within the pancreas. J Int Coll Surg 23:675–699
Beger HG, Krautzberger W, Bittner R, Büchler M, Limmer J (1985) Duodenum-preserving resection of the head of the pancreas in patients with severe chronic pancreatitis. Surgery 97:467–473
Bockman DE (1987) Gut-associated macrophages. In: Brostoff J, Challacombe SJ (eds) Food allergy and intolerance. Baillière Tindall, London, pp 67–87
Bockman DE (1988) Systems underlying involvement of the duodenum in pancreatic disease. Pancreas 3:592
Bockman DE, Boydston WR, Anderson MC (1982) Origin of tubular complexes in human chronic pancreatitis. Am J Surg 144:243–249
Bockman DE, Büchler M, Malfertheiner P, Beger HG (1988) Analysis of nerves in chronic pancreatitis. Gastroenterology 94:1459–1469
Durack DT, Ackerman SJ, Loegering DA, Gleich GJ (1981) Purification of human eosinophil-derived neurotoxin. Proc Natl Acad Sci USA 78:5165–5169
Frey CF (1973) Ninety-five percent pancreatectomy. In: Carey LC (ed) The pancreas. Mosby, St Louis, pp 202–229
Keith RG, Keshavjee SH, Kerenyi NR (1982) Neuropathology of chronic pancreatitis in humans. Can J Surg 28:207–211
Kirchgessner AL, Gershon MD (1989) Innervation of the rat’s pancreas: analysis of direct projections from neurons in myenteric ganglia of the duodenum and stomach and intrapancreatic ganglia. Gastroenterology 96:A258
Odaira C, Koizumi M, Sawai T (1987) Quantitative study on tissue mast cells in pancreatic disease. Digestion 38:50
Richins CA (1945) The innervation of the pancreas. J Comp Neurol 83:223–236
Tiscornia OM (1977) The neural control of exocrine and endocrine pancreas. Am J Gastroenterol 67:541–560
White TT (1982) Pain. In: Bradley EL III (ed) Complications of pancreatitis. Saunders, Philadelphia, pp 203–222
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bookman, D.E., Büchler, M., Malfertheiner, P., Beger, H.G. (1990). Morphology of Nerves in Chronic Pancreatitis and the Interrelationship with Inflammatory Tissue. In: Beger, H.G., Büchler, M., Ditschuneit, H., Malfertheiner, P. (eds) Chronic Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75319-0_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-75319-0_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75321-3
Online ISBN: 978-3-642-75319-0
eBook Packages: Springer Book Archive