Gastritis and Altered Motility; the Ability of a Mucosal Inflammatory Reaction to Alter Enteric Nerve and Smooth Muscle in the Gut
Dyspeptic symptoms such as pain, nausea, and vomiting, that accompany gastritis, and which are sometimes refractory to gastric acid suppression, may arise from disturbances in gastric motility. Indeed, motility disturbances have been described in several studies on patients with active gastric ulceration [6, 11]. In addition, Liebermann-Meffert and Allgöwer  demonstrated hypertrophy of muscle and structural alterations in enteric nerves in specimens resected from patients with gastric ulcer; Hiatt and Katz  showed increased numbers of mast cells in the muscle layers below gastric ulcer craters.
KeywordsMast Cell Celiac Disease Peptic Ulcer Disease Bile Reflux Enteric Nerve
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- 1.Alizadeh H, Weems WA, Castro GA (1986) Immunologically induced alterations in the intrinsic state of guinea pig jejunum (Abstr). Gastroenterology 91: A1042.Google Scholar
- 2.Biancani P, Barwick K, Selling J, McCallum R (1984) Effects of acute experimental “esophagitis” on mechanical properties of the lower esophageal sphincter. Gastroenterology 87 (1):8–16.Google Scholar
- 4.Collins SM, Blennerhassett P, Vermillion DL, Blennerhassett M (1990) Altered myenteric plexus function in Trichinella-infected rats. Am J Physiol (in press).Google Scholar
- 8.Kern F, Almy TP, Abbott FK, Bogdonoff MD (1952) The motility of the distal colon in nonspecific ulcerative colitis. Gastroenterology 19:492–503.Google Scholar
- 9.Lieberman-Meffert D, Allgöwer M (1977) The morphology of antrum-pylorus in gastric ulcer disease. Prog Surg 15:109–139.Google Scholar
- 10.Marzio L, Blennerhassett P, Chiverton S, Vermillion D, Collins SM (1986) Systemic factors are responsible for altered smooth muscle function in the inflamed gut. Gastroenterology 94 (5):A286.Google Scholar
- 14.Muller MJ, Huizinga JD, Collins SM (1990) Altered smooth muscle contraction and sodium pump activity in the inflamed rat intestine. Am J Physiol (in press).Google Scholar
- 18.Swain M, Blennerhassett P, Collins SM (1989) Intestinal inflammation alters sympathetic nerve function in the rat myenteric plexus. Gastroenterology 96:A498.Google Scholar
- 21.Vermillion DL, Collins SM (1989) Mast cells contract human intestinal muscle via the release of P.A.F. and leukotriene D4 in patients with or without Crohn’s disease. Gastroenterology 96: A 527.Google Scholar
- 23.Vermillion DL, Ernst PB, Collins SM (1989) Altered smooth muscle function in the inflamed gut is T lymphocyte dependent. Gastroenterology 96: A 528.Google Scholar
- 24.Vignjevic P, Blennerhassett MG, Blennerhassett P, Vermillion DL, Collins SM (1989) Hypertrophy and hyperplasia of smooth muscle in the inflamed intestine. Gastroenterology 96:A530.Google Scholar