Abstract
For a long time studies of gut-associated immunity concentrated on the small and large bowel, but almost neglected the stomach as an organ without significant immunocompetence. Attention increasingly turned to the gastric immune system, since the common B cell gastric lymphoma was reassessed to be an archetype of lymphoproliferative disease in mucosa-associated lymphoid tissue (MALT) [11, 20]. Moreover, the rediscovery of spiral bacteria on the gastric mucosa [31], which were defined as a new bacterial genus called Helicobacter pylori (HP) [9], decisively stimulated the interest in gastric immunity. Up to now a growing body of evidence emphasizes that the most common type B gastritis is induced by HP and that it may reflect a mucosal immune response to the exogenous bacterial antigens [4, 8, 19, 26, 32]. Therefore, histologic evaluations of gastritis require an immunologic basis, and the immunohistochemistry could provide some insight into the local immune response induced by the HP colonization.
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Kirchner, T., Melber, A., Fischbach, W., Heilmann, K.L., Müller-Hermelink, H.K. (1990). Immunohistological Patterns of the Local Immune Response in Helicobacter pylori Gastritis. In: Malfertheiner, P., Ditschuneit, H. (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75315-2_33
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DOI: https://doi.org/10.1007/978-3-642-75315-2_33
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