Abstract
For a long time studies of gut-associated immunity concentrated on the small and large bowel, but almost neglected the stomach as an organ without significant immunocompetence. Attention increasingly turned to the gastric immune system, since the common B cell gastric lymphoma was reassessed to be an archetype of lymphoproliferative disease in mucosa-associated lymphoid tissue (MALT) [11, 20]. Moreover, the rediscovery of spiral bacteria on the gastric mucosa [31], which were defined as a new bacterial genus called Helicobacter pylori (HP) [9], decisively stimulated the interest in gastric immunity. Up to now a growing body of evidence emphasizes that the most common type B gastritis is induced by HP and that it may reflect a mucosal immune response to the exogenous bacterial antigens [4, 8, 19, 26, 32]. Therefore, histologic evaluations of gastritis require an immunologic basis, and the immunohistochemistry could provide some insight into the local immune response induced by the HP colonization.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brandtzaeg P (1985) The human secretory immune system: general review. In: Revillard JP, Voisin C, Wierzbicki N (eds) Mucosal immunity. IgA and polymorphonuclear neurophils. Journee Immunologiques — Fondation Franco-Allemande, Paris, pp 11–43.
Brandtzaeg P, Sollid LM, Thrane PS, Kvale D, Bjerke K, Scott H, Kett K, Rognum TO (1988) Lymphoepithelial interactions in the mucosal immune system. Gut 29:1116–1130.
Brassens-Rabbe MP, Megraud F, Teyssou R, Vialette G (1989) Specific IgA response to Campylobacter pylori in gastric mucosa. Klin Wochenschr [Suppl 18] 67:7.
Correa P, Munoz N, Cuello C, Fox J, Zavala D, Ruiz B (1989) The role of Campylobacter pylori in gastro-duodenal disease. In: Fenoglio-Preiser C, Wolff M, Rilke F (eds) Progress in surgical pathology, vol 10. Field and Woods, Philadelphia, pp 191–210.
Dixon FM, Wyatt JI, Burke DA, Rathbone BJ (1988) Lymphocytic gastritis — relationship to Campylobacter pylori infection. J Pathol 154:125–132.
Dobbins WO III (1986) Human intestinal intraepithelial lymphocytes. Gut 27:972–985.
Engstrand L, Scheynius A, Pahlson C, Grimelius L, Schwan A, Gustavsson S (1989) Association of Campylobacter pylori with induced expression of class II transpalantation antigens on gastric epithelial cells. Infect Immun 57:827–832.
Goodwin CS, Armstrong JA, Marshall BJ (1986) Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol 39:353–365.
Goodwin CS, Armstrong JA, Chilvers T, Peters M, Collins MD, Sly L, McConnell W, Harper WES (1989) Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustelae comb, nov., respectively. Int J Syst Bacteriol 39:397–405.
Isaacson P (1982) Immunoperoxidase study of the secretory immunoglobulin system and lysozyme in normal and diseased gastric mucosa. Gut 23:578–588.
Isaacson PG, Spencer J (1987) Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 11:445–462.
Janeway CA Jr (1988) Frontiers of the immune system. Nature 333:804–806.
Janeway CA Jr, Bottomly K, Babich J (1984) Quantitative variations in Ia antigen expression plays a central role in immune regulation. Immunol Today 5:99–105.
Janeway CA Jr, Jones B, Hayday A (1988) Specificity and function of T cells bearing γδ receptors. Immunol Today 9:73–76.
Kawanishi H (1987) Immunocompetence of normal human appendiceal lymphoid cells: in vitro studies. Immunology 60:19–28.
Kvale D, Lövhaug D, Sollid LM, Brandtzaeg P (1988) Tumor necrosis factor-α upregulates expression of secretory component, the epithelial receptor for polymeric Ig. J Immunol 140:3086–3089.
Matis LA, Glimcher LH, Paul WE, Schwartz RH (1983) Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci USA 80:6019–6023.
Mestecky J, McGhee J (1987) Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol 40:153–245.
Musgrove C, Bolton FJ, Krypczyk AM, Temperly JM, Cairns SA, Owen WG, Hutchinson DN (1988) Campylobacter pylori: clinical, histological, and serological studies. J Clin Pathol 41:1316–1321.
Myhre MJ, Isaacson PG (1987) Primary B-cell gastric lymphoma-a reassessment of its histogenesis. J Pathol 152:1–11.
Papadimitriou CS, Ioachim-Velogianni EE, Tsianos EB, Moutsopoulos HM (1988) Epithelial HLA-DR expression and lymphocyte subsets in gastric mucosa in type B chronic gastritis. Virchows Arch [A] 413:197–204.
Rathbone BJ, Wyatt JI, Tompkins D, Heatley RV, Losowsky MS (1986) In vitro production of Campylobacter pyloridis specific antibodies by gastric mucosal biopsies. Gut 27: A607.
Sollid LM, Gaudernack G, Markussen G, Kvale D, Brandtzaeg P, Thorsby E (1987) Induction of various HLA class II molecules in a human colonic adenocarcinoma cell line. Scand J Immunol 25:175–180.
Sollid LM, Kvale D, Brandtzaeg P, Markussen G, Thorsby E (1987) Interferon-α enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins. J Immunol 138:4303–4306.
Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG (1989) Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 30:339–346.
Stolte M, Eidt S, Ritter M, Bethke B (1989) Campylobacter pylori und Gastritis. Assoziation oder Induktion? Pathologe 10:21–26.
Thrane PS, Brandtzaeg P, Huitfeldt H (1986) Spatial relationship between IgA-positive cells and epithelium expressing HLA class II determinants in salivary glands (Abstr 1.14.13) International Congress on Immunology, Toronto.
Tsutsumi Y, Nagura H, Watanabe K (1984) Immune aspects of intestinal metaplasia of the stomach: an immunohistochemical study. Virchows Arch [A] 403:345–359.
Vaines K, Brandtzaeg P, Elgjo I, Stave R (1984) Specific and non-specific humoral defense factors in the epithelium of normal and inflamed gastric mucosa. Immunohistochemical localization of immunoglobulins, secretory component, lysozyme, and lactoferrin. Gastroenterology 86:402–412.
Vecchi M, Berti E, Primignani M, Monti M, Agape D, Torgano G, Arosio E, de Franchis R (1985) In situ identification of immune competent cells in gastrointestinal mucosa: an evaluation by immunoelectron microscopy. Virchows Arch [A] 406:407–415.
Warren JR, Marshall BJ (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273–1275.
Wyatt JI, Rathbone BJ, Heatley RV (1986) Local immune response to gastric Campylobacter in non-ulcer dyspepsia. J Clin Pathol 39:863–870.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kirchner, T., Melber, A., Fischbach, W., Heilmann, K.L., Müller-Hermelink, H.K. (1990). Immunohistological Patterns of the Local Immune Response in Helicobacter pylori Gastritis. In: Malfertheiner, P., Ditschuneit, H. (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75315-2_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-75315-2_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75317-6
Online ISBN: 978-3-642-75315-2
eBook Packages: Springer Book Archive