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Serum Antibodies to the Vacuolating Toxin Produced by Helicobacter pylori

  • N. Figura
  • O. Fanti
  • P. Guglielmetti
  • A. Barberi
  • A. Rossolini
  • A. Zanchi
  • M. G. Cusi
  • R. A. Musmanno
  • M. Russi
  • S. Quaranta
Conference paper

Abstract

Cytotoxin is one of the candidate factors of virulence of Helicobacter pylori (HP) [1]. Toxigenicity occurs frequently in strains isolated from patients with peptic ulceration [2], and there is serological evidence that cytotoxin production also occurs in vivo. In fact, in immunoblotting tests we saw that all the 31 individuals infected by cytotoxic (CT+) HP strains tested and 14 of 20 patients (70%) infected by noncytotoxic (CT) organisms had serum immunoglobulin G (IgG) which recognized HP cytotoxin-associated proteins (CAP). IgA to CAP were hardly detected, mostly in patients infected by CT+ strains, while IgM were not detected at all (N. Figura et al., in preparation).

Keywords

Rapid Urease Test Immunoblotting Technique Brucella Broth Immunoblotting Test Cytotoxin Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR (1988) Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol 26:93–99.PubMedCrossRefGoogle Scholar
  2. 2.
    Figura N, Guglielmetti P, Rossolini A, Barberi A, Cusi G, Musmanno RA, Russi M, Quaranta S (1989) Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 27:225–226.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • N. Figura
    • 1
    • 2
    • 3
  • O. Fanti
    • 1
    • 2
    • 3
  • P. Guglielmetti
    • 1
    • 2
    • 3
  • A. Barberi
    • 1
    • 2
    • 3
  • A. Rossolini
    • 1
    • 2
    • 3
  • A. Zanchi
    • 1
    • 2
    • 3
  • M. G. Cusi
    • 1
    • 2
    • 3
  • R. A. Musmanno
    • 1
    • 2
    • 3
  • M. Russi
    • 1
    • 2
    • 3
  • S. Quaranta
    • 1
    • 2
    • 3
  1. 1.Istituto di Malattie InfettiveUniversità di SienaSienaItaly
  2. 2.Istituto di MicrobiologiaUniversità di SienaItaly
  3. 3.Servizio di Gastroenterologia, Divisione Medica IIOspedale di GrossetoItaly

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