Serum Antibodies to the Vacuolating Toxin Produced by Helicobacter pylori

  • N. Figura
  • O. Fanti
  • P. Guglielmetti
  • A. Barberi
  • A. Rossolini
  • A. Zanchi
  • M. G. Cusi
  • R. A. Musmanno
  • M. Russi
  • S. Quaranta
Conference paper

Abstract

Cytotoxin is one of the candidate factors of virulence of Helicobacter pylori (HP) [1]. Toxigenicity occurs frequently in strains isolated from patients with peptic ulceration [2], and there is serological evidence that cytotoxin production also occurs in vivo. In fact, in immunoblotting tests we saw that all the 31 individuals infected by cytotoxic (CT+) HP strains tested and 14 of 20 patients (70%) infected by noncytotoxic (CT) organisms had serum immunoglobulin G (IgG) which recognized HP cytotoxin-associated proteins (CAP). IgA to CAP were hardly detected, mostly in patients infected by CT+ strains, while IgM were not detected at all (N. Figura et al., in preparation).

Keywords

Hydroxide Sulfuric Acid Sodium Hydroxide Gastritis Sera 

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References

  1. 1.
    Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR (1988) Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol 26:93–99.PubMedCrossRefGoogle Scholar
  2. 2.
    Figura N, Guglielmetti P, Rossolini A, Barberi A, Cusi G, Musmanno RA, Russi M, Quaranta S (1989) Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 27:225–226.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • N. Figura
    • 1
    • 2
    • 3
  • O. Fanti
    • 1
    • 2
    • 3
  • P. Guglielmetti
    • 1
    • 2
    • 3
  • A. Barberi
    • 1
    • 2
    • 3
  • A. Rossolini
    • 1
    • 2
    • 3
  • A. Zanchi
    • 1
    • 2
    • 3
  • M. G. Cusi
    • 1
    • 2
    • 3
  • R. A. Musmanno
    • 1
    • 2
    • 3
  • M. Russi
    • 1
    • 2
    • 3
  • S. Quaranta
    • 1
    • 2
    • 3
  1. 1.Istituto di Malattie InfettiveUniversità di SienaSienaItaly
  2. 2.Istituto di MicrobiologiaUniversità di SienaItaly
  3. 3.Servizio di Gastroenterologia, Divisione Medica IIOspedale di GrossetoItaly

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