Serum Antibodies to the Vacuolating Toxin Produced by Helicobacter pylori
Cytotoxin is one of the candidate factors of virulence of Helicobacter pylori (HP) . Toxigenicity occurs frequently in strains isolated from patients with peptic ulceration , and there is serological evidence that cytotoxin production also occurs in vivo. In fact, in immunoblotting tests we saw that all the 31 individuals infected by cytotoxic (CT+) HP strains tested and 14 of 20 patients (70%) infected by noncytotoxic (CT−) organisms had serum immunoglobulin G (IgG) which recognized HP cytotoxin-associated proteins (CAP). IgA to CAP were hardly detected, mostly in patients infected by CT+ strains, while IgM were not detected at all (N. Figura et al., in preparation).
KeywordsHydroxide Sulfuric Acid Sodium Hydroxide Gastritis Sera
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