Abstract
A large number of investigators have agreed that H. pylori is an emerging candidate as an agent for the genesis of gastritis and peptic ulcers. There have been rapid advances in our knowledge of H. pylori infection, but as with many human diseases, progress in the understanding of H. pylori gastritis would be increased if there were available for experimental use an animal model of the infection. For future research high priority should be given to the development of a challenge model in an animal that is raised conventionally. The development of such a model may help to fulfil Koch’s postulate and to clarify the pathogenetic mechanisms as well as therapeutic regimens.
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References
Van der Gaag I (1988) The histological appearance of peroral gastric biopsies in clinically healthy and vomiting dogs. Can J Vet Res 52:67–74.
O’Brien JJ (1969) Gastric ulceration (of the pars oesophagea) in the pig. Vet Bull 39:75–82.
Kowalczyk T (1975) Gastric ulcers. In: Dunne HW, Leman AG (eds) Diseases of swine, 4th edn. Iowa State University Press, Ames, pp 978–1010.
Jubb KVF, Kennedy PC, Palmer N (1985) Pathology of domestic animals, 3rd edn. Academic, New York.
Bronsdon MA, Schoenknecht FD (1988) Campylobacter pylori isolated from the stomach of the monkey Macaca nemestrina. J Clin Microbiol 26:1725–1728.
Baskerville A, Newell DG (1988) Naturally occurring chronic gastritis and Campylobacter pylori infection in the rhesus monkey: a potential model for gastritis in man. Gut 29:465–472.
Ehlers S, Warrelmann M, Hahn H (1988) In search of an animal model for experimental Campylobacter pylori infection: administration of Campylobacter pylori to rodents. Zentralbl Bacteriol Microbiol Hyg 268:341–346.
Krakowka S, Morgan DR, Kraft WG, Leund RD (1987) Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet. Infect Immun 55:2789–2796.
Lambert JR, Borromeo M, Pinkard KJ, Turner H, Chapman CB, Smith ML (1987) Colonization of gnotobiotic piglets with Campylobacter pyloridis an animal model? J Infect Dis 155:1344.
Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ (1985) Attempt to fulfil Koch’s postulates for pyloric campylobacter. Med J Aust 142:436–439.
Duriex D, Westblom TU, Madan E, Midkiff BR, Subik M (1990) Gastric concentrations of ciprofloxacin in a guinea pig model: a comparison to in vitro susceptibilities in human isolates of Campylobacter pylori. In: Marshall B, McCallum R, Peterson W (eds) Gastroduodenal disease and Campylobacter pylori. Blackwell, Cambridge (in press)
Rosberg K, Hubinette R, Berglindh T, Rolfsen W (1989) Studies of Campylobacter pylori in a gastric mucosa in vitro model. Klin Wochenschr [Suppl] 67:59–60.
Lingwood CA, Law H, Pellizzari A, Sherman P, Drumm B (1989) Gastric glyceriolipid as a receptor for Campylobacter pylori. Lancet 2:238–241.
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© 1990 Springer-Verlag Berlin Heidelberg
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Engstrand, L. (1990). Animal Models of Helicobacter pylori Gastritis. In: Malfertheiner, P., Ditschuneit, H. (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75315-2_18
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DOI: https://doi.org/10.1007/978-3-642-75315-2_18
Publisher Name: Springer, Berlin, Heidelberg
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