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Pharmacology of Nimodipine — A Review

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Stabilizing Craniocervical Operations Calcium Antagonists in SAH Current Legal Issues

Part of the book series: Advances in Neurosurgery ((NEURO,volume 18))

Abstract

Among Ca2+ antagonists (Ca2+ channel antagonists, Ca2+ entry blockers, CAs) several drugs were reported to have anti-ischemic, anticonvulsant, or other effects on the central nervous system. One Ca2+ antagonist, nimodipine, was approved in the United States for prevention of neurological deficits in patients with subarachnoid hemorrhage. Some CAs are being used for the treatment of focal and global cerebral ischemia and other disorders of the central nervous system. This article reviews pharmacological properties of nimodipine which justify its use in some disorders of the central nervous system. It updates previous reviews on the same subject [28–30].

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Authors and Affiliations

  1. Miles Institute for Preclinical Pharmacology, 06516, West Haven, CT, USA

    A. Scriabine

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  1. A. Scriabine
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Editors and Affiliations

  1. Neurochirurgische Universitätsklinik, Josef-Schneider-Straße 11, D-8700, Würzburg, Germany

    K.-A. Bushe

  2. Neurochirurgische Klinik und Poliklinik, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    Mario Brock

  3. Neurochirurgische Klinik, Universität Erlangen-Nürnberg, Schwabachanlage 6 (Kopfklinikum), D-8520, Erlangen, Germany

    Margareta Klinger

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© 1990 Springer-Verlag Berlin Heidelberg

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Scriabine, A. (1990). Pharmacology of Nimodipine — A Review. In: Bushe, KA., Brock, M., Klinger, M. (eds) Stabilizing Craniocervical Operations Calcium Antagonists in SAH Current Legal Issues. Advances in Neurosurgery, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75283-4_29

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  • DOI: https://doi.org/10.1007/978-3-642-75283-4_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51967-6

  • Online ISBN: 978-3-642-75283-4

  • eBook Packages: Springer Book Archive

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