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Genetic Resistance to a Retroviral Neurologic Disease in Wild Mice

  • Conference paper
Book cover Retrovirus Infections of the Nervous System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 160))

Abstract

The only known example of a naturally occurring oncoviral neurologic disease in animals is the fatal hind leg paralysis described in an aging population of wild mice (Mus musculus) from an isolated squab farm near Lake Casitas (LC) in southern California (Officer et al. 1973; Gardner et al. 1973). The disease, called spongiform polioencephalomyelopathy, is caused by an infectious (ecotropic) murine leukemia virus (MuLV) and is characterized by a noninflammatory, nonimmunogenic, direct retrovirus injury to anterior horn neurons in the lumbosacral spinal cord. The observation that this virus and its associated paralysis are detected in only a small minority (10%) of the LC mice is explained by the segregation in this outbred population of a dominant ecotropic-MuLV restriction gene, initially called Akrv-1 and now called FV-4. In this chapter I briefly summarize the natural history of this retroviral neurologic disease, for which several recent reviews are available (Gardner 1978; Gardner and Rasheed 1982; Gardner 1985), and cover more recent information on the discovery, structure, and function of this MuLV restriction gene.

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Author information

Authors and Affiliations

  1. Department of Medical Pathology, University of California, Davis, California, 95616, USA

    M. B. Gardner

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  1. M. B. Gardner
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Editors and Affiliations

  1. Dept. of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski M.D. (Direktor) (Direktor)

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© 1990 Springer-Verlag Berlin · Heidelberg

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Gardner, M.B. (1990). Genetic Resistance to a Retroviral Neurologic Disease in Wild Mice. In: Oldstone, M.B.A., Koprowski, H. (eds) Retrovirus Infections of the Nervous System. Current Topics in Microbiology and Immunology, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75267-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-75267-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75269-8

  • Online ISBN: 978-3-642-75267-4

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