Abstract
The dimorphic fungus, Candida albicans, grows best under aerobic conditions, although it does exhibit a limited degree of anaerobic growth. Growth rates of C. albicans show substantial variations according to the strain and culture conditions used. Under optimal conditions it can achieve maximal doubling times of just under 1 h [29,99].
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References
Aerts RJ, Durston AJ, Konijn TM (1987) Cytoplasmic pH at the onset of development in Dictyostelium. J Cell Science 87: 423
Alvarez A, McKinnon JE (1957) “Lethal” variant of Candida albicans, a “petite colonie” mutant. Science 126:399
Aly R, Maibach H (1983) Susceptibility to skin infection. In: Rook AJ, Maibach H (eds) Recent advances in dermatology, no 6. Churchill Livingstone, Edinburgh, p 75
Anderson JM, Soll DR (1984) Effects of zinc on stationary-phase phenotype and macromolecular synthesis accompanying outgrowth of Candida albicans. Infect Immun 46: 13
Aoki S, Ito-Kuwa S (1982) Respiration of Candida albicans in relation to its morphogenesis. Plant Cell Physiol 23: 721
Aoki S, Ito-Kuwa S (1984) The appearance and characterization of cyanide-resistant respiration in the fungus Candida albicans. Microbiol Immunol 28: 393
Aoki S, Ito-Kuwa S (1987) Induction of petite mutation with acriflavine and elevated temperatures in Candida albicans. J Med Vet Mycol 25: 269
Balish E (1973) Methionine biosynthesis and S-adenosyl methionine degradation during an induced morphogenesis of Candida albicans. Can J Microbiol 19: 847
Balish E (1973) S-adenosylmethionine metabolism by members of the genus Candida. Can J Microbiol 19: 1297
Bartinicki-Garcia S, Lippman E (1968) Fungal morphogenesis-cell wall construction in Mucor rouxii. Science 165: 302
Bedard DP, Singer RA, Johnston GC (1986) Transient cell cycle arrest of the yeast Saccharomyces cerevisiae by the amino acid analog beta-2-DL-thienylalanine. J Bacteriol 141: 100
Borgers M, DeNollin S, Thone F, Belle H Van (1977) Cytochemical localization of NADH oxidase in Candida albicans. J Histochem Cytochem 25: 193
Borgess M, Bossche H van den (1982) The mode of action of antifungal drugs. In: Levine HB (ed) Ketoconazole in the management of fungal disease. ADIS, Australia, p 25
Brown WM, Prager EM, Wang A, Wilson AC (1982) Mitochondrial DNA sequences of primates: tempo and mode of evolution. J Mol Evol 18: 225
Bulder CJEA (1964) Induction of petite mutation and inhibition of synthesis of respiratory enzymes in various yeasts. Anton Leeuwen 30: 1
Bulder CJEA (1964) Lethality of the petite mutation in petite negative yeasts. Anton Leeuwen 30: 442
Cassone A, Sullivan PA, Shepherd MG (1985) N-acetyl-D-glucosamine- induced morphogenesis in Candida albicans. Microbiologica 58: 85
Chaffin WL (1985) Effect of tunicamycin on germ tube and yeast bud formation in Candida albicans. Can J Microbiol 131: 1853
Chiew YY (1989) The dynamics of carbohydrate metabolism in Candida albicans. Exp Mycol 13: 49
Chin CM, Shepherd MG, Sullivan PA (1975) Cyanide insensitive respiration in Candida albicans. Proc Univ Otago Med Sch 53: 42
Cutler JE, Hazen KC (1983) Yeast/mold morphogenesis. In: Bunnet JW, Cieger A (eds) Secondary metabolism and differentiation in fungi, vol 5. Dekker, New York, p 267
Dabrowa N, Howard DH (1983) Blastoconidium germination. In: Howard DH (ed) Fungi pathogenic for humans and animals. Dekker, New York, p 525
Davison MT, Garland PB (1977) Structure of mitochondria and vacuoles of Candida utilis and Schizosaccharomyces pombe studied by electron microscopy of aerial thin sections and model building. J Gen Microbiol 98: 147
Downie JA, Garland PB (1973) An antimycin A and cyanide-resistant variant of Candida utilis arising during copper-limited growth. Biochem J 134: 1051
Dudani AK, Prasad R (1985) Differences in amino acid transport and phospholipid contents during the cell cycle of Candida albicans. Folia Microbiol 30: 493
Edwards DL, Rosenberg E (1976) Regulation of cyanide-insensitive respiration in Neurospora crassa. Eur J Biochem 62: 217
Edwards DL, Rosenberg E, Maroney PA (1974) Induction of cyanide insensitive respiration in N. crassa. J Biol Chem 249: 3351
Eklund T, Jarmud T (1983) Microculture model studies on the effect of various gas atmospheres on microbial growth at different temperatures. J Appl Bacteriol 55: 119
Evans EGV, Odds FC, Richardson MD, Holland KT (1974) The effect of growth medium on filament production in Candida albicans. Sabouraudia 12: 112
Fiechter A, Fuhrman GF, Kapell O (1981) Regulation of glucose metabolism in growing yeast cells. Adv Microbial Physiol 22: 123
Frame G W, Strauss WG, Maibach HI (1972) Carbon dioxide and emission of the human arm and hand. J Invest Dermatol 59: 155
Funato A (1979) Electron microscope studies on Candida tropicalis in synchronous culture with special reference to three-dimensional structure of its mitochondrion. J Tokyo Med Coll 37: 693
Gow NAR, Gooday GW (1982) Growth kinetics and morphology of colonies of the filamentous form of Candida albicans. J Gen Microbiol 128: 2187
Gow NAR, Gooday GW (1987) Cytological aspects of dimorphism in Candida albicans. CRC Crit Rev Microbiol 15: 73
Gow NAR, Henderson G, Gooday GW (1986) Cytological relationships between the cell cycle and duplication cycle of Candida albicans. Microbios 47: 97
Grappel SF, Calderone RA (1976) Effect of antibodies on the respiration and morphology of Candida albicans. Sabouraudia 14: 51
Guerin M, Camougrand N (1986) The alternate oxidase of Candida parapsilosis. Eur J Biochem 159: 519
Hasilik A, Livar M (1972) The effect of 4-bromobenzyl isothiocyanate on the redox state of nicotinamide-adenine dinucleotides in Candida albicans. Chem Biol Interact 4: 305
Hauswirth WW, Laipis PJ (1982) Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. Proc Natl Acad Sei USA 79: 4686
Henry MF, Hamaide-Deplus MC, Nyns EJ (1974) Cyanide-insensitive respiration of Candida albicans. Anton Leeuwen 40: 79
Henry MF, Bonner WD, Nyns EJ Jr (1977) Involvement of iron in the biogenesis of the cyanide-insensitive respiration in the yeast Saccharomycopsis lipolytica. Biochim Biophys Acta 460: 94
Holmes AR, Shepherd MG (1987) Proline induced germ-tube formation in Candida albicans’. role of prolice uptake and nitrogen metabolism. J Gen Microbiol 133: 3219
Holmes AR, Shepherd MG (1988) Nutritional factors determine germ tube formation in Candida albicans. J Med Vet Mycol 26: 127
Iralu V (1971) Formation of aerial hyphae in Candida albicans. Appl Microbiol 22: 482
Ito-Kuwa S, Aoki S, Watanabe T, Ehara T, Osafune T (1988) Fluorescence microscopic studies on mitochondria and mitochondrial nucleoids in a wild-type strain and respiratory mutants of Candida albicans. J Med Vet Mycol 26: 207
Jayakumar A, Singh M, Prasad R (1978) Characteristics of proline transport in normal and starved cells of Candida albicans. Biochim Biophys Acta 514: 348
Johnston GC, Singer RA (1978) RNA synthesis and control of cell division in the yeast Saccharomyces cerevisiae. Cell 14: 951
Kennedy MJ (1981) Inhibition of Candida albicans by the anaerobic oral flora of mice in vitro. Sabouraudia 19: 205
Kockova-Kratochvilova A, Stuchlik V, Pokorna M (1964) The genus Candida Berkhout. V. Basic nutrition of Candida albicans in static culture. Folia Microbiol 9: 361
Kot EJ, Rolewic LJ, Olson VC, McClary DO (1975) Growth, respiration and cytology of acetate-negative mutants of Candida albicans. Anton Leeuwen 41: 229
Kot EJ, Olson VL, Rolewic LJ, McClary DO (1976) An alternate respiratory pathway in Candida albicans. Anton Leeuwen 42: 33
Lambowitz AW, Slayman CW (1971) Cyanide resistant respiration in Neurospora crassa. J Bacteriol 108: 1087
Land GA, McDonald WC, Stjernholm RL, Friedman L (1975) Factors affecting filamentation in Candida albicans. Relationship of the uptake and distribution of proline to morphogenesis in Candida albicans. Infect Immun 11: 1014
Land GA, McDonald WC, Stjernholm RL, Friedman L (1975) Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicansdm’mg fermentation. Infect Immun 12: 119
Laties GG (1982) The cyanide resistant, alternative respiratory path in higher plant respiration. Annu Rev Plant Physiol 33: 519
Lee KL, Buckley HR, Campbell CC (1975) An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 13: 148
Littman ML, Miwatani T (1963) Effect of water soluble vitamins and their analogues on the growth of Candida albicans. I. Biotin, pyridoxamine, pyridoxine and fluorinated pyrimidines. Mycopathol Mycol Appl 21: 81
Littman ML, Miwatani T (1963) Effect of water soluble vitamins and their analogues on growth of Candida albicans. II. Vitamin B, substituted pyrimidines and thiazoles. Mycopathol Mycol Appl 21: 298
Littman ML, Miwatani T (1964) Effect on water soluble vitamins and their analogues on growth of Candida albicans. III. Para-amino-benzoic acid, nicotinic acid, inositol and their analogues. Mycopathol Mycol Appl 22: 117
Loomis WF (1982) The development of Dictyostelium discoedium. Acacemic Press, London
Makinen KK, Ojanotko A, Vidgren H (1975) Effect of xylitol on the growth of three oral strains of Candida albicans. J Dent Res 54: 1239
Mardon D, Balish E, Philliphs AW (1969) Control of dimorphism in a biochemical variant of Candida albicans. J Bacteriol 100: 701
Maresca B, Lambowitz AL, Kobayashi GS, Medoff GL (1979) Respiration in the yeast and mycelial phases of Histoplasma capsulatum. J Bacteriol 138: 647
Maresca B, Kumar BV, Medoff J, Medoff G, Kobayashi GS (1980) Studies on dimorphism in H. capsulatum. Biochemical changes during the differentiation process. In: Dreusser HJ (ed) Medical mycology. Fisher, New York, p 17
McClary DO (1952) Factors affecting the morphology of Candida albicans. Ann Mo Bot Gard 39: 137
McDonald SA, Durston AJ (1984) The cell cycle and sorting behaviour in Dictyostelium discoeidium. J Cell Sei 66: 195
McFeeters GA, Wilson DF, Strobel GA (1970) Cytochromes in a cyanide resistant strain of Bacillus cereus. Can J Microbiol 16: 1221
Miller SE, Finnerty WR (1979) Age related physiological studies comparing Candida albicans chlamydospores to yeasts. Can J Microbiol 25: 765
Miller SE, Spurlock BO, Michaelis GE (1974) Electron microscopy of young Candida albicans chlamydospores. J Bacteriol 119: 992
Mizuno N, Montes LF (1966) Oxidative enzyme activity in Candida albicans. Sabouraudia 5: 46
Mounolou JC, Jakob H, Slonimski PP(1986) Mitochondrial DNA from yeast “petite” mutants: specific changes of bouyant density corresponding to different cytoplasmic mutations. Biochem Biophys Res Commun 12: 448
Nagai S (1963) Diagnostic color differentiation plates for hereditary respiration deficiency in yeast. J Bacteriol 86: 299
Nickersen WJ (1963) Symposium on biochemical basis of morphogenesis in fungi. Bacteriol Rev 27: 305
Nickersen W J, Falcone G (1956) Identification of protein disulfide reductase as a cellular division enzyme in yeasts. Science 124: 722
Nickersen WJ, Van Rij NJW (1949) The effect of sulfhydryl compounds, penicillin and cobalt on the cell division mechanism of yeasts. Biochim Biophys Acta 3: 461
Niimi M, Tokunaga M, Nakayama H (1986) Regulation of mannitol catabolism in Candida albicans: evidence for cyclic-AMP dependent glucose effect. J Med Vet Mycol 24: 211
Niimi M, Kamiyama A, Tokunaga M, Nakayama H (1987) Evidence for glucose effect on N-acetyl glucosamine catabolism in Candida albicans. Can J Microbiol 33: 345
Niimi M, Kamiyama A, Tokunaga M (1988) Respiration of medically important Candida species and Saccharomyces cerevisiae in relation to glucose effect. J Med Vet Mycol 26: 195
Odds FC (1985) Morphogenesis in Candida albicans. CRC Crit Rev Microbiol 12: 45
Odds FC (1988) Candida and candidosis, 2nd edn. Balliere Tindall, London
Odds FC, Abbott AB (1980) A simple system for the presumptive identification of Candida albicans and differentiation of strains within the species. Sabouraudia 18: 301
Oivo PD, Memanus EJ, Riggsby WS, Jones JM (1987) Mitochondria DNA polymorphism in Candida albicans. J Infect Dis 156: 214
Paris S, Duran-Gonzalez S, Mariat F (1985) Nutritional studies on Paracoccidiodies brasilensis: the role of organic sulphur in dimorphism. Sabouraudia 23: 85
Persi MA, Burnham JC (1981) Use of tannic acid as a fixative mordant to improve the ultrastructural appearance of Candida albicans blastospores. Sabouraudia 19: 1
Petrik M, Kappeli O, Fiechter A (1983) An expanded concept for the glucose effect in the yeast Saccharomyces uvarum: involvement of short- and long-term regulation. J Gen Microbiol 129: 43
Pitillo RF, Narkates AJ (1964) Folic acid inhibition of non-proliferating bacteria. Can J Microbiol 10: 345
Pollack JH, Hashimoto T (1985) Ethanol induced germ tube formation in Candida albicans. J Gen Microbiol 131: 3303
Portillo F, Gancedo C (1984) Mode of action of miconazole on yeasts: inhibition of mito¬chondrial ATPase. Eur J Biochem 143: 273
Restrepo A, Salzar ME, Cano LE, Stover EP, Feldman D, Stevens DA (1984) Estrogens inhibit mycelium to yeast transformation in the fungus Paracoccidiodies brasilensis’. implications for resistance of females to paracoccidioidomycosis. Infect Immun 47: 346
Ruiz-Herrera J (1985) Dimorphism in Mucor species with emphasis on M. rouxii and M. bacilliformis. In: Szaniszlo PJ (ed) Fungal dimorphism. Plenum, London, p 361
Rustin P, Dupont J, Lance C (1983) A role for fatty acid peroxy radicals in the cyanide-in- sensitive pathway of plant mitochondria? Tr Biochem Sei 8: 155
Rustin P, Dupont J, Lance C (1983) Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mito¬chondria. Arch Biochem Biophys 225: 630
Rustin P, Dupont J, Lance C (1984) Involvement of lipid peroxy radicals in the cyanide-resistant electron transport pathway. Physiol Veg 22: 643
Samarnayake LP, Geddes D, Weetman D, Macfarlane TW (1983) Growth and acid production of Candida albicans in carbohydrate supplemented media. Microbios 37: 105
San Blas F, San Blas G, Inglow D (1980) Dimorphism in Paracoccidiodies brasilensis. In: Preusser HJ (ed) Medical mycology. Fisher, New York, p 23
Schwarz J (1971) The pathogenesis of Histoplasmosis. In: Ajello L, Chick EW, Furcolow ML (eds) Histoplasmosis proceedings. Thomas, Springfield, 111, p 244
Shah DM, Langley CH (1979) Inter- and intra-specific variations in restriction maps of Drosophila mitochondrial DNAs. Nature 281: 696
Shepherd MG (1988) Morphogenetic transformation in fungi. Curr Topics Med Mycol 2: 278
Shepherd MG, Sullivan PA (1976) The production and growth characteristics of yeast and mycelial forms of Candida albicans in continuous cultures. J Gen Microbiol 93: 361
Shepherd MG, Chin CM, Sullivan PA (1978) The alternate respiratory pathway of Candida albicans. Arch Microbiol 116: 61
Shepherd MG, Poulter RTM, Sullivan PA (1985) Candida albicans’, biology, genetics and pathogenecity. Annu Rev Microbiol 39: 579
Shigematsu ML, Uno J, Arai T (1982) Effect of ketoconazole on isolated mitochondria from Candida albicans. Antimicrob Agents Chemother 21: 919
Singer RA, Johnston GC, Bedard D (1978) Methionine analogs and cell division regulation in the yeast, Saccharomyces cerevisiae. Proc Natl Acad Sei USA 75: 6083
Singh B, Gupta KC (1972) Effect of growth-regulating substances on the biomass and lipids of some fungi. Zentralbl Bakteriol (A) 220: 554
Singh M, Jayakumar A, Prasad R (1978) The effect of altered lipid composition on the transport of various amino acids in Candida albicans. Arch Biochem Biophys 191: 680
Singh M, Jayakumar A, Prasad R (1979) Lipid composition and polyene antibiotic sensitivity in isolates of Candida albicans. Microbios 24: 7
Sims W (1986) Effects of carbon dioxide on the growth and form of Candida albicans. J Med Microbiol 22: 203
Soll DR (1984) The cell cycle and commitment to alternate cell fates in Candida albicans. In: Nurse P, Streiblova E (eds) The microbial cell cycle. CRC, Boca Raton, p 143
Soli DR (1986) The regulation of cellular differentiation in the dimorphic yeast Candida albicans. Bioessays 5: 5
Soll DR, Bedell GW, Brummell M (1981) Zinc and the regulation of growth and phenotype in the infectious yeast Candida albicans. Infect Immun 32: 1139
Staebell M, Soli DR (1985) Temporal and spatial differences in cell wall expansion during bud and mycelium formation in Candida albicans. J Gen Microbiol 131: 1467
Stevens B (1981) Mitochondrial structure. In: Strathern JN, Jones EW, Broach JR (eds) The molecular biology of the yeast Saccharomycescerevisiae. Life cycle and inheritance. Cold Spring Harbor Laboratory, New York, p 471
Szaniszlo PJ, Jacobs CW, Gels PA (1983) Dimorphism: morphological and biochemical aspects. In: Howard DH (ed) Fungi pathogenic for humans and animals, part A. Dekker, New York, p 323
Tanaka K, Kanbe T, Kuroiwa T (1985) Three dimensional behaviour of mitochondria during cell division and germ tube formation in the dimorphic yeast Candida albicans. J Cell Sei 73: 207
Taylor JW, Wells K (1979) The mitochondrion in mitotic and starved cells of Bullera alba. Exp Mycol 3: 16
Teranishi Y, Shimizu S, Tanaka A, Fukui S (1974) Comparative studies on respiratory activity and cytochrome content of Candida tropicalis pK 233 grown on hydrocarbon and on glucose. Agric Biol Chem 28: 1581
Vanderleyden J, Kurth J, Verchtert H (1979) Characterization of cyanide insensitive respiration in mitochondria and submitchondrial particles of Moniliella tomentosa. Biochem J 182: 437
van Urk H, Mak PR, Scheffers WA, Van Dijken JP (1988) Metabolic responses of Saccha- romyces cerevisiae CBS 8066 and Candida utilis CBS 621 upon transition from glucose limitation to glucose excess. Yeast 4: 283
Ward JM, Nickersen WJ (1958) Respiratory metabolism of normal and divisionless strains of Candida albicans. J Gen Physiol 41: 703
Watkins PD, Brandt PM, McClary DO (1974) Selection and characterization of acriflavine induced mutants of Candida albicans. Anton Leeuwen 40: 153
Webster CE, Odds FC (1987) Growth of pathogenic Candida isolates anaerobically and under elevated concentrations of C02 in air. J Med Vet Mycol 25: 47
Williamson DH, Finnell DJ (1975) The use of fluorescent DNA — binding agent for detecting and separating yeast mitochondrial DNA. Methods Cell Biol 12: 335
Wills JW, Troutman WB, Riggsby WS (1985) Circular mitochondrial genome of Candida albicans contains a large inverted duplication. J Bacteriol 164: 7
Yamaguchi H (1974) Dimorphism in Candida albicans. I. Morphology-dependent changes in cellular content of macromolecules and respiratory activity. J Gen Appl Microbiol 20: 87
Yamaguchi H, Kanda Y, Iwata K (1971) Biochemical properties of mitochondria from Candida albicans. Sabouraudia 9: 221
Yamaguchi H, Kanda Y, Osumi M (1974) Dimorphism in Candida albicans. II. Comparison of fine structure of yeast-like and filamentous phase growth. J Gen Appl Microbiol 20: 101
Yamaguchi H, Hiiatani T, Osumi M, Iwata K (1982) Isolation and characterization of mutants, especially respiratory deficient mutants, of Candida albicans. Jpn J Med Mycol 23: 132
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Anand, S., Prasad, R. (1991). Growth and Respiration Characteristics of Candida albicans . In: Prasad, R. (eds) Candida Albicans. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75253-7_4
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