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Candida Albicans pp 144–163Cite as

Adherence of Candida albicans: Influencing Factors and Mechanism(s)

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Abstract

Interest in the study of adherence of microorganisms to various surfaces has increased tremendously in recent years. This is understandable, as the elucidation of this process throws light on the mechanism of pathogenesis and may lead to a means of controlling infections before their onset. Evidence that adherence may be the initial step in candidosis and its involvement in the colonization process of C. albicans came from work carried out by King et al. [49] and Liljemark and Gibbons [57], respectively. In this chapter we will review (1) methods used to measure adhesion of C. albicans; (2) factors affecting the adhesion process; (3) surface characteristics and adherence; (4) mechanisms of adhesion; and (5) in vivo adherence and its implication to candidosis. Due to space limitation, we have resorted in a number of occasions to referring the reader to key references.

Keywords

  • Fibril
  • Lactose
  • Cavitation
  • Lactobacillus
  • Glycoside

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abu-Elteen K, Ghannoum MA, Stretton RJ (1989) Effect of subinhibitory concentrations of antifungal agents on adherence of Candida spp. to buccal epithelial cells in vitro. Mycoses 32: 551

    CAS  Google Scholar 

  2. Anderson ML, Odds FC (1985) Adherence of Candida albicans to vaginal epithelial significance of morphological form and effect of ketoconazole. Mykosen 28: 531

    PubMed  CAS  Google Scholar 

  3. Annaix V, Aubry J, Robert R, Bouali A, Tronchin G, Senet J-M (1987) Fibrinogen binding on Candida albicans germ-tubes and mycelium. Protides Biol Fluids 35: 399

    CAS  Google Scholar 

  4. Aronson M, Medalia O, Schori L, Mirelman D, Sharon N, Ofek I (1979) Prevention of colonization of the urinary tract of mice with Escherichia coli by blocking of bacterial adherence with methyl-D-mannopyranoside. J Infect Dis 139: 329

    PubMed  CAS  Google Scholar 

  5. Balish E, Balish MJ, Salkowski CA, Lee KW, Bartzal KF (1984) Colonization of congenitally athymic, gnotobiotic mice by Candida albicans. Appl Environ Microbiol 47: 647

    PubMed  CAS  Google Scholar 

  6. Barnes JL, Osgood W, Lee JC, King RD, Stein JH (1983) Host-parasite interactions in the pathogenesis of experimental renal candidiasis. Lab Inves 49: 460

    CAS  Google Scholar 

  7. Barrett-Bee K, Hayes Y, Wilson RG, Ryley JF (1985) A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts. J Gen Microbiol 131: 1217

    PubMed  CAS  Google Scholar 

  8. Borg M, Ruchel R (1988) Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa. Infect Immun 56: 626

    PubMed  CAS  Google Scholar 

  9. Botta GA (1981) Possible role of hormones in the observed changes in adhesion of several microorganisms to epithelial cells from different body sites. FEMS Microbiol Lett 11: 69

    Google Scholar 

  10. Bouali A, Robert R, Tronchin G, Senet J-M (1986) Binding of human fibrinogen to Candida albicans in vitro: a preliminary study. J Med Vet Mycol 24: 345

    PubMed  CAS  Google Scholar 

  11. Bouali A, Robert R, Tronchin G, Senet J-M (1987) Characterization of binding of human fibrinogen to the surface of germ-tubes and mycelium of Candida albicans. J Gen Microbiol 133: 545

    PubMed  CAS  Google Scholar 

  12. Calderone RA, Scheid WM (1987) Role of fibronectin in the pathogenesis of candidal infections. Rev Infect Dis 9: S400

    PubMed  CAS  Google Scholar 

  13. Calderone RA, Lehrer N, Segal E (1984) Adherence of Candida albicans to buccal and vaginal epithelial cells: ultrastructural observations. Can J Microbiol 30: 1001

    PubMed  CAS  Google Scholar 

  14. Centeno A, David CP, Cohen MS, Warren MM (1983) Modulation of Candida albicans attachment to human epithelial cells by bacteria and carbohydrates. Infect Immun 39: 1354

    PubMed  CAS  Google Scholar 

  15. Christensen GD, Simpson A, Beachey EH (1985) Adhesion of bacteria to animal tissues-complex mechanisms. In: Savage DC, Fletche M (eds) Bacterial adhesion: mechanisms and physiological significance. Plenum, New York, p 279

    Google Scholar 

  16. Cole GT, Seshan KR, Pope LM, Yancey RJ (1988) Morphological aspects of gastrointestinal tract invasion by Candida albicans in the infant mouse. J Med Vet Mycol 26: 173

    PubMed  CAS  Google Scholar 

  17. Collins-Lech C, Kalbfleisch JH, Franson TR, Sohnle PG (1984) Inhibition by sugars oi Candida albicans adherence to human buccal mucosal cells and corneocytes in vitro. Infect Immun 46: 831

    PubMed  CAS  Google Scholar 

  18. Cox F (1983) Adherence of Candida albicans to buccal epithelial cells in children and adults. J Lab Clin Med 102: 960

    PubMed  CAS  Google Scholar 

  19. Cox F (1986) Candida albicans adherence in newborn infants. J Med Vet Mycol 24: 121

    PubMed  CAS  Google Scholar 

  20. Critchley IA, Douglas LJ (1987) Role of glycosides as epithelial cell receptors for Candida albicans. J Gen Microbiol 133: 637

    PubMed  CAS  Google Scholar 

  21. Davidson S, Brish M, Rubinstein E (1984) Adherence of Candida albicans to buccal epithelial cells of neonates. Mycopathologia 85: 171

    Google Scholar 

  22. Diamond RD, Krzesicki R (1978) Mechanisms of attachment of neutrophils to Candida albicans pseudohyphae in the absence of serum and of subsequent damage to pseudohyphae by microbicidal processes of neutrophils in vitro. J Clin Invest 61: 360

    CAS  Google Scholar 

  23. Douglas LJ (1987) Adhesion of Candida species to epithelial surfaces. CRC Crit Rev Microbiol 15: 27

    CAS  Google Scholar 

  24. Epstein JB, Kimura LH, Menard TW, Truelove EL, Pearsall NN (1982) Effects of specific antibodies on the interaction between the fungus Candida albicans and human oral mucosa. Arch Oral Biol 27: 469

    PubMed  CAS  Google Scholar 

  25. Ghannoum MA (1988) Mechanisms potentiating Candida infections. A review. Mycoses 31: 543

    PubMed  CAS  Google Scholar 

  26. Ghannoum MA (1990) Inhibition of Candida adhesion to buccal epithelial cells by an aqueous extract of Allium sativum (garlic). J Appl Bacteriol 68: 163

    PubMed  CAS  Google Scholar 

  27. Ghannoum MA, Abu-Elteen K (1986) Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans. J Med Vet Mycol 24: 407

    PubMed  CAS  Google Scholar 

  28. Ghannoum MA, Abu-Elteen K (1987) Effect of growth of Candida spp. in the presence of various glucocorticoids on the adherence to human buccal epithelial cells. Mycopathol 98: 171

    CAS  Google Scholar 

  29. Ghannoum MA, Radwan SS (1990) Candida adherence to epithelial cells. CRC, Boca Raton

    Google Scholar 

  30. Ghannoum MA, Burns GR, Abu-Elteen K, Radwan SS (1986) Experimental evidence for the role of lipids in adherence of Candida spp. to human buccal epithelial cells. Infect Immun 54: 189

    PubMed  CAS  Google Scholar 

  31. Ghannoum MA, Abu-Elteen K, Radwan SS (1987) Blocking adherence of Candida albicans to buccal epithelial cells by yeast glycolipids, yeast wall lipids and lipids from epithelial cells. Mykosen 30: 371

    PubMed  CAS  Google Scholar 

  32. Ghannoum MA, Abu-Elteen K, Motawy MS (1988) Effect of antineoplastic agents and X- irradiation on the adherence of Candida spp. to human buccal epithelial cells in vitro. Mycopathologia 104: 171

    PubMed  CAS  Google Scholar 

  33. Gorman SP, McCafferty DF, Woolfson AD, Jones DS (1987) Reduced adherence of microorganisms to human mucosal epithelial cells following treatment with taurolin, a noval antimicrobial agent. J Appl Bacteriol 62: 315

    PubMed  CAS  Google Scholar 

  34. Hazen KC (1989) Participation of yeast cell surface hydrophobicity in adherence of Candida albicans to human epithelial cells. Infect Immun 57: 1894

    PubMed  CAS  Google Scholar 

  35. Hazen KC, Plotkin BJ, Klimas DM (1986) Influence of growth condition on cell surface hydrophobicity of Candida albicans and Candida glabrata. Infect Immun 54: 269

    PubMed  CAS  Google Scholar 

  36. Howlett JA, Squier A (1980) Candida albicans ultrastructure: colonization and invasion of oral epithelium. Infect Immun 29: 252

    PubMed  CAS  Google Scholar 

  37. Jones GW (1977) The attachment of bacteria to the surfaces of animal cells. In: Reissig JL (ed) Microbial interactions, receptors and recognition series B, vol 3. Chapman & Hall, London, p 139

    Google Scholar 

  38. Jones GW, Isaacson RE (1983) Proteinaceous bacterial adhesins and their receptors. Crit Rev Microbiol 10: 229

    PubMed  CAS  Google Scholar 

  39. Joshi KR, Wheeler EE, Gavin JR (1973) Scanning electron microscopy of colonies of six species of Candida. J Bacteriol 115: 341

    PubMed  CAS  Google Scholar 

  40. Joshi KR, Gavin JR, Armiger LC (1975) Intracellular matrix in colonies of Candida. J Bacteriol 123: 1139

    PubMed  CAS  Google Scholar 

  41. Kearns MJ, Davies P, Smith H (1983) Variability of the adherence of Candida albicans strains to human buccal epithelial cells: inconsistency of differences between strains related to virulence. Sabouraudia 21: 93

    PubMed  CAS  Google Scholar 

  42. Kennedy MJ (1988) Adhesion and association mechanisms of Candida albicans. In: McGinnis MR (ed) Current topics in medical mycology, vol 2. Springer, Berlin Heidelberg New York, p 73

    Google Scholar 

  43. Kennedy MJ, Sandin RL (1988) Influence of growth condition on Candida albicans adhesion, hydrophobicity and cell wall ultrastructure. J Med Vet Mycol 26: 79

    PubMed  CAS  Google Scholar 

  44. Kennedy MJ, Volz PA, Edwards CA, Yancey RJ (1987) Mechanisms of association of Candida albicans with intestinal mucosa. J Med Microbiol 24: 333

    PubMed  CAS  Google Scholar 

  45. Kennedy MJ, Rogers AL, Hanseimen LR, Soll DR, Yancey RJ (1988) Variation in adhesion and cell surface hydrophobicity in Candida albicans white and opaque phenotypes. Mycopathologia 102: 149

    PubMed  CAS  Google Scholar 

  46. Kennedy MJ, Rogers AL, Yancey RJ (1989) Environmental alteration and phenotypic regulation of Candida albicans adhesion to plastic. Infect Immun 57: 3876

    PubMed  CAS  Google Scholar 

  47. Kimura LH, Pearsall NN (1978) Adherence of Candida albicans to human buccal epithelial cells. Infect Immun 21: 64

    PubMed  CAS  Google Scholar 

  48. Kimura LH, Pearsall NN (1980) Relationship between germination of Candida albicans and increased adherence to human buccal epithelial cells. Infect Immun 28: 464

    PubMed  CAS  Google Scholar 

  49. King RD, Lee JC, Morris AL (1980) Adherence of Candida albicans and other Candida species to mucosal epithelial cells. Infect Immun 27: 667

    PubMed  CAS  Google Scholar 

  50. Klotz SA (1987) The adherence of Candida yeasts to human and bovine vascular endothelium and subendothelial extracellular matrix. FEMS Microbiol Lett 48: 201

    CAS  Google Scholar 

  51. Klotz SA, Penn RL (1987) Multiple mechanisms may contribute to the adherence of Candida yeasts to living cells. Curr Microbiol 16: 119

    Google Scholar 

  52. Klotz SA, Maca RD (1988) Endothelial cell contraction increases Candida adherence to exposed extracellular matrix. Infect Immun 56: 2495

    PubMed  CAS  Google Scholar 

  53. Klotz SA, Dutz DJ, Harrison JL, Huppert M (1983) Adherence and penetration of vascular endothelium by Candida yeasts. Infect Immun 42: 374

    PubMed  CAS  Google Scholar 

  54. Klotz SA, Drutz DJ, Zajic JE (1985) Factors governing adherence of Candida species to plastic surfaces. Infect Immun 50: 97

    PubMed  CAS  Google Scholar 

  55. Kuo SC, Lampen JO (1974) Tunicamycin - an inhibitor of yeast glycoprotein synthesis. Biochem Biophys Res Commun 58: 287

    PubMed  CAS  Google Scholar 

  56. Lee JC, King RD (1983) Adherence mechanisms of Candida albicans. In: Schlessinger D (ed) Microbiology. American Society for Microbiology, Washington DC, p 269

    Google Scholar 

  57. Liljemark WF, Gibbons RJ (1973) Suppression of Candida albicans by human oral streptococci in gnotobiotic mice. Infect Immun 8: 846

    PubMed  CAS  Google Scholar 

  58. Macura AB (1987) Hydrophobicity of Candida albicans related to their adherence to mucosal epithelial cells. Zentralbl Bakteriol Hyg A 266: 491

    CAS  Google Scholar 

  59. Macura AB (1988) The influence of some antifungal drugs on in vitro adherence of Candida albicans to human buccal epithelial cells. Mycoses 31: 371

    PubMed  CAS  Google Scholar 

  60. Maisch PA, Calderone RA (1980) Adherence of Candida albicans to a fibrin-platelet matrix formed in vitro. Infect Immun 27: 650

    PubMed  CAS  Google Scholar 

  61. Marrie TJ, Costerton JW (1981) The ultrastructure of Candida albicans infections. Can J Microbiol 27: 1156

    PubMed  CAS  Google Scholar 

  62. Marshall KC, Stout R, Mitchell R (1971) Mechanism of the initial events in the sorption of marine bacteria to surfaces. J Gen Microbiol 68: 337

    CAS  Google Scholar 

  63. McCourtie J, Douglas LJ (1981) Relationship between cell surface composition of Candida albicans and adherence to acrylic after growth on different carbon sources. Infect Immun 32: 1234

    PubMed  CAS  Google Scholar 

  64. McCourtie J, Douglas LJ (1984) Relationship between cell surface composition, adherence and virulence of Candida albicans. Infect Immun 45: 6

    PubMed  CAS  Google Scholar 

  65. McCourtie J, MacFarlane TW, Samaranayake LP (1986) A comparison of the effects of Chlorhexidine gluconate, amphotericin B and nystatin on the adherence of Candida species to denture acrylic. J Antimicrob Chemother 17: 575

    PubMed  CAS  Google Scholar 

  66. Mehentee JF, Hay RJ (1989) In vitro adherence of Candida albicans strains to murine gastrointestinal mucosal cells and explants and the role of environmental pH. J Gen Microbiol 135: 2181

    PubMed  CAS  Google Scholar 

  67. Minagi S, Miyake Y, Inagaki K, Tsuru H, Suginaka H (1985) Hydrophobic interaction in Candida albicans and Candida tropicalis adherence to various denture base resin materials. Infect Immun 47: 11

    PubMed  CAS  Google Scholar 

  68. Minagi S, Miyake Y, Fugioka Y, Tsuru H, Suginaka H (1986) Cell-surface hydrophobicity of Candida species as determined by the contact-angle and hydrocarbon-adherence methods. J Gen Microbiol 132: 1111

    PubMed  CAS  Google Scholar 

  69. Odds FC (1988) Candida and candidosis. A review and bibliography. Bailliere-Tindall, London

    Google Scholar 

  70. Odds FC, Webster CE (1988) Effects of azole antifungals in vitro on host/parasite interactions relevant to Candida infections. J Antimicrob Chemother 22: 473

    PubMed  CAS  Google Scholar 

  71. Page S, Odds FC (1988) Binding of plasma proteins to Candida species in vitro. J Gen Microbiol 134: 2693

    PubMed  CAS  Google Scholar 

  72. Persi MA, Burnham JC, Duhring JL (1985) Effects of carbon dioxide and pH on adhesion of Candida albicans to vaginal epithelial cells. Infect Immun 50: 82

    PubMed  CAS  Google Scholar 

  73. Pope LM, Cole GT (1981) SEM studies of adherence of Candida albicans to the gastrointestinal tract of infant mice. Scand Electron Microsci 3: 73

    Google Scholar 

  74. Pugh D, Cawson RA (1978) The surface layer of Candida albicans. Microbios 23: 19

    PubMed  CAS  Google Scholar 

  75. Ray TL, Payne CD (1988) Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: a role for Candida acid proteinase. Infect Immun 56: 1942

    PubMed  CAS  Google Scholar 

  76. Ray TL, Digre KB, Payne CD (1984) Adherence of Candida species to human epidermal corneocytes and buccal mucosal cells: correlation with cutaneous pathogenicity. J Invest Dermatol 83: 37

    PubMed  CAS  Google Scholar 

  77. Rossano F, Tufano MA (1975) Effect of concanavalin A on the adhesiveness of Candida albicans to vaginal cells. Rass Med Sper 22: 313

    CAS  Google Scholar 

  78. Rotrosen D, Gibson TR, Edwards JE (1983) Adherence of Candida species to intravenous catheters. J Infect Dis 147: 594

    PubMed  CAS  Google Scholar 

  79. Rotrosen D, Edwards JE, Gibson TR, Moore JC, Cohen AH, Green I (1985) Adherence of Candida to cultured vascular endothelial cells: mechanisms of attachment and endothelial cell penetration. J Infect Dis 152: 1264

    PubMed  CAS  Google Scholar 

  80. Rotrosen D, Calderone RA, Edwards JE (1986) Adherence of Candida species to host tissues and plastic surfaces. Rev Infect Dis 8: 73

    PubMed  CAS  Google Scholar 

  81. Samaranayake LP, MacFarlane TW (1980) An in vitro study of the adherence of Candida albicans to acrylic surfaces. Arch Oral Biol 25: 603

    PubMed  CAS  Google Scholar 

  82. Samaranayake LP, MacFarlane TW (1981) The adhesion of the yeast Candida albicans to epithelial cells of human origin. Arch Oral Biol 26: 815

    PubMed  CAS  Google Scholar 

  83. Samaranayake LP, MacFarlane TW (1982) Factors affecting the in vitro adherence of the fungal oral pathogen Candida albicans to epithelial cells of human origin. Arch Oral Biol 27: 869

    Google Scholar 

  84. Samaranayake LP, McCourtie J, MacFarlane TW (1980) Factors affecting the in vitro adherence of Candida albicans to acrylic surfaces. Arch Oral Biol 25: 611

    PubMed  CAS  Google Scholar 

  85. Sande MA, Bowman CR, Calderone RA (1977) Experimental Candida albicans endocarditis: characterization of the disease and response to therapy. Infect Immun 17: 140

    PubMed  CAS  Google Scholar 

  86. Sandin RL (1987) Studies on cell adhesion and concanavalin A-induced agglutination of Candida albicans after mannan extraction. J Med Microbiol 24: 145

    PubMed  CAS  Google Scholar 

  87. Sandin RL, Rogers AL (1982) Inhibition of adherence of Candida albicans to human epithelial cells. Mycopathol 77: 23

    CAS  Google Scholar 

  88. Sandin RL, Rogers AL, Patterson RJ, Beneke ES (1982) Evidence for mannose-mediated adherence of Candida albicans to human buccal cells in vitro. Infect Immun 35: 79

    PubMed  CAS  Google Scholar 

  89. Sandin RL, Rogers AL, Beneke ES, Fermandez MI (1987) Influence of mucosal cell origin on the in vitro adherence of Candida albicans: are mucosal cells from different sources equivalent? Mycopathologia 98: 111

    PubMed  CAS  Google Scholar 

  90. Sato Y, Arai H, Suzuki K (1974) Leukocytosis-promoting factor for Bordetella pertussis. II. Its identity with protective antigen. Infect Immun 9: 801

    Google Scholar 

  91. Segal E, Savage D (1986) Adhesion of Candida albicans to mouse intestinal mucosa in vitro: development of the assay and test of inhibitors. J Med Vet Mycol 24: 477

    PubMed  CAS  Google Scholar 

  92. Segal E, Lehrer N, Ofek I (1982) Adherence of Candida albicans to human vaginal epithelial cells: inhibition by amino sugars. Exp Cell Biol 50: 13

    PubMed  CAS  Google Scholar 

  93. Segal E, Soroka A, Schechter A (1984) Correlative relationship between adherence of Candida albicans to human vaginal epithelial cells in vitro and candidal vaginitis. Sabouraudia 22: 191

    PubMed  CAS  Google Scholar 

  94. Segal E, Gottfried L, Lehrer N (1988) Candidal vaginitis in hormone treated mice. Prevention by a chitin extract. Mycopathologia 102: 157

    Google Scholar 

  95. Shibl AM (1985) Effect of antibiotics on adherence of microorganisms to epithelial cell surfaces. Rev Infect Dis 7: 51

    PubMed  CAS  Google Scholar 

  96. Skerl KG, Calderone A, Segal E, Streevalson T, Scheid WM (1984) In vitro binding of Candida albicans yeast cells to human fibronectin. Can J Microbiol 30: 221

    PubMed  CAS  Google Scholar 

  97. Sobel JD, Obedeanu N (1983) Effects of subinhibitory concentrations of ketoconazole on in vitro adherence of Candida albicans to vaginal epithelial cells. Eur J Clin Microbiol 2: 445

    PubMed  CAS  Google Scholar 

  98. Sobel JD, Myers PG, Kaye D, Levison ME (1981) Adherence of Candida albicans to human vaginal and buccal epithelial cells. J Infect Dis 143: 76

    PubMed  CAS  Google Scholar 

  99. Sobel JD, Myers P, Levison ME, Kaye D (1982) Comparison of bacterial and fungal adherence to vaginal exfoliated epithelial cells and human vaginal epithelial tissue culture cells. Infect Immun 35: 697

    PubMed  CAS  Google Scholar 

  100. Sobel JD, Muller G, Buckley HR (1984) Critical role of germ-tube formation in the pathogenesis of candidal vaginitis. Infect Immun 44: 576

    PubMed  CAS  Google Scholar 

  101. Soll DR, Langtimm CJ, McDowell J, Hicks J, Galask R (1987) High frequency switching in Candida strains isolated from vaginitis patients. J Clin Microbiol 25: 1611

    PubMed  CAS  Google Scholar 

  102. Suegara N, Siegel JE, Savage DC (1979) Ecological determinants in microbial colonization of the murine gastrointestinal tract: adherence of Torulopsis pintolopesii to epithelial surfaces. Infect Immun 25: 139

    PubMed  CAS  Google Scholar 

  103. Tkaez JS, Cybulska EB, Lampen JO (1971) Specific staining of wall mannan in yeast cells with fluorescein-conjugated concanavalin A. J Bacteriol 105: 1

    Google Scholar 

  104. Tobgi RS, Samaranayake LP, MacFarlane TW (1987) Adhesion of Candida albicans to buccal epithelial cells exposed to Chlorhexidine. J Med Vet Mycol 25: 335

    PubMed  CAS  Google Scholar 

  105. Tokunaga M, Niimi M, Koike H (1988) Electron microscopic observation of adherence of Candida albicans to human buccal epithelial cells using rapid freezing technique. In : X Congress International Society for Human and Animal Mycology Poster No 122, Barcelona

    Google Scholar 

  106. Tomsikova A, Kotal L, Novackova D (1987) The role of adherence of Candida species in the pathogenesis of vaginal and oral candidiasis. Mykosen 30: 74

    PubMed  CAS  Google Scholar 

  107. Tronchin G, Poulain D, Vernes A (1984) Cytochemical and ultrastructural studies of Candida albicans. III. Evidence for modifications of the cell wall coat during adherence to human buccal epithelial cells. Arch Microbiol 139: 221

    PubMed  CAS  Google Scholar 

  108. Tronchin G, Robert R, Bouali A, Senet J-M (1987) Immunocytochemical localization of in vitro binding of human fibrinogen to Candida albicans germ-tube and mycelium. Ann Inst Pasteur Microbiol 138: 177

    PubMed  CAS  Google Scholar 

  109. Tronchin G, Bouchara J-P, Robert R, Senet J-M (1988) Adherence of Candida albicans germ-tubes to plastic: ultrastructural and molecular studies of fibrillar adhesins. Infect Immun 56: 1987

    PubMed  CAS  Google Scholar 

  110. Vuddhakul V, McCormack JG, Seow WK, Thong YH (1989) Inhibitory effects of human neutrophil granules and oxygen radicals on adherence of Candida albicans. J Med Microbiol 29: 181

    PubMed  CAS  Google Scholar 

  111. Vudhichamnog K, Walter DM, Ryley HC (1982) The effect of secretory immunoglobulin A on the in vitro adherence of the yeast Candida albicans to human oral epithelial cells. Arch Oral Biol 27: 617

    Google Scholar 

  112. Walker PD, Nagy LK ( 1980) Adhesion of organisms to animal tissues. In : Berkeley RC W, Lynch JM, Meiling J, Rutter PR, Vincent B (eds) Microbial adhesion to surfaces, Chapter 26. Ellis Horwood, Chichester

    Google Scholar 

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  1. Department of Botany and Microbiology, Kuwait University, P.O. Box 5969, Safat, 13060, State of Kuwait

    M. A. Ghannoum & K. Abu-Elteen

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  1. M. A. Ghannoum
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  1. School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, 110067, New Delhi, India

    Prof. Dr. Rajendra Prasad

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Ghannoum, M.A., Abu-Elteen, K. (1991). Adherence of Candida albicans: Influencing Factors and Mechanism(s). In: Prasad, R. (eds) Candida Albicans. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75253-7_10

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