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Subsets of Rat CD4+ T Cells Defined by Their Differential Expression of Variants of the CD45 Antigen: Developmental Relationships and In Vitro and In Vivo Functions

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Book cover Immunological Memory

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 159))

Abstract

Thymus-derived lymphocytes have been shown to mediate a wide range of immunological functions both as direct effectors in cell-mediated immunity and as helper or inducer cells for B cells, macrophages, bone marrow cells and other T cells. In addition, the lymphokines that they produce have been shown to act not only on leucocytes but also on non-bone marrow derived cells. This wide range of T-cell functions has only recently been fully appreciated, but early work using alloantisera in mice established that T cells with different functional specializations could be distinguished phenotypically on the basis of whether or not they expressed what came to be called the CD8 antigen (Cantor and Boyse 1975).

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Authors and Affiliations

  1. Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    F. Powrie & D. Mason

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  1. F. Powrie
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  2. D. Mason
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    David Gray Ph.D.

  2. Dept. of immunology-IMM4A, Research Inst. of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Jonathan Sprent M.B., B.S., Ph.D. (Member) (Member)

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© 1990 Springer-Verlag Berlin Heidelberg

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Powrie, F., Mason, D. (1990). Subsets of Rat CD4+ T Cells Defined by Their Differential Expression of Variants of the CD45 Antigen: Developmental Relationships and In Vitro and In Vivo Functions. In: Gray, D., Sprent, J. (eds) Immunological Memory. Current Topics in Microbiology and Immunology, vol 159. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75244-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-75244-5_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75246-9

  • Online ISBN: 978-3-642-75244-5

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