Antiviral T-Cell Memory?

  • R. M. Zinkernagel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 159)

Abstract

Generally, it is accepted that immunological memory exists at both the B- and the T-cell level (reviewed in Katz 1977). It has been known for more than 100 years that the persistence of high antibody titers (Fig. 1) can be lifelong after viral infections and that delayed-type hypersensitivity can be demonstrated for a long time by challenging with a protein antigen after prior infection with tubercle bacilli. The concept of providing protection from disease by vaccination depends entirely on the existence of immunological memory. Although evidence for B-cell memory is abundant (Katz 1977), it is not clear whether it is maintained by means of (a) persistence of antigen, (b) continuous exposure to cross-reactive “natural” environmental antigen, or (c) the existence of true memory B cells.

Keywords

Albumin Influenza Bacillus Sarcoma Halflife 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. M. Zinkernagel
    • 1
  1. 1.Institute of PathologyUniversity HospitalZürichSwitzerland

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