The Generation of B-Cell Memory: A Working Hypothesis

  • N. R. Klinman
  • P.-J. Linton
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 159)


The process by which secondary B cells are generated has intrigued immunologists for several decades. This is particularly true since appropriate antigenic stimulation leads both to a selective increase in the frequency of B cells responsive to the immunizing antigen and to the generation of a population of cells (secondary B cells) that are phenotypically and functionally distinct from primary B cells specific for the same antigen.


Somatic Mutation Secondary Response Somatic Hypermutation Variable Region Gene Unequal Division 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • N. R. Klinman
    • 1
  • P.-J. Linton
    • 1
  1. 1.Department of ImmunologyResearch Institute of Scripps ClinicLa JollaUSA

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