Monoclonal (Auto)Antibodies in Insulin-Dependent Diabetes Mellitus

Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 156)


Insulin-dependent diabetes mellitus (IDDM) in humans, BB rats (MARLISS 1983), and nonobese diabetic (NOD) mice (MAKINO et al. 1980) is characterized by immune abnormalities leading to self-destruction of the insulin-producing islet β cells. These abnormalities have been observed in the cell-mediated as well as in the humoral immune response. Two major types of auto-antibodies have been reported, namely, islet cell cytoplasmic (ICA; BOTTAZZO et al. 1974; MAUISH et al. 1974) and islet cell surface antibodies (ICSA; LERNMARK et al. 1978). In this chapter we will review data on experimental monoclonal antibodies to islet cells with a special emphasis on autoantibodies derived from the BB rat.


Islet Cell Islet Cell Antibody Islet Hormone Insulin Autoantibody Human Insulin Gene 
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© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  1. 1.Hagedorn Research LaboratoryGentofteDenmark

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