Effects of Rubella Virus Infection on Islet Function

Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 156)


Viruses have been linked to the subsequent development of diabetes mellitus for at least 90 years (HARRIS 1899). The evidence to support environmental factors comes from a variety of studies including case reports in the literature, especially in regard to the congenital rubella syndrome (GINSBERG-FELLNER et al. 1985). The association of diabetes mellitus with the congenital rubella syndrome (CRS) provides the most compelling data that viruses may be directly accountable for the later onset of diabetes (RAYFIELD and ISHIMURA 1987). This chapter will first review data from human studies and then present evidence from animal models to support an association of CRS with diabetes mellitus. This is a logical sequence since it was the observations from the human studies which prompted the development of the animal models.


Rubella Virus Golden Syrian Hamster Islet Function Hamster Model Congenital Rubella Syndrome 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  1. 1.Laboratory of Medical BiochemistryRockefeller UniversityNew YorkUSA

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