Autoantigen (64000-Mr) Expression in Coxsackievirus B4-Induced Experimental Diabetes

Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 156)


Extensive epidemiologic observations (GAMBLE et al. 1969; GAMBLE 1980; BARRET-CONNOR 1985), many case reports, and animal studies (CRAIGHEAD 1975; NOTKINS 1977) have associated group B coxsackieviruses in the etiology of type 1, insulin-dependent diabetes mellitus (IDDM). IDDM in human patients is rare until 9 months of age and has peaks of onset at 5–8 years and again at 10–14 years of age (GAMBLE 1977). These observations are consistent with epidemiological patterns of many infections, which are prevented by maternal immunity and have peaks at the time of entry into school and at early puberty.


Beta Cell IDDM Patient Susceptible Mouse Insulin mRNA Islet Cell Antigen 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  1. 1.New York State Department of HealthWadsworth Center for Laboratories and ResearchAlbanyUSA

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