Zusammenfassung
Neuroleptika besitzen ihre Domäne in der Behandlung produktiver Psychosen. Sie sind speziell in der Therapie der schizophrenen Erkrankungen unverzichtbar. Zahlreiche Langzeituntersuchungen zum Verlauf der schizophrenen Psychosen dokumentieren einerseits eine bunte Vielfalt der Verlaufsgestalten, sprechen also klar gegen einen monolithischen und progredienten Krankheitsprozeß (Bleuler 1972; Ciompi u. Müller 1976; Huber et al. 1979). Sie zeigen aber andererseits auch, daß ca. 2/3 der einmal an einer schizophrenen Psychose erkrankten Patienten wiederholt längerfristig oder auch dauernd Neuroleptika einnehmen müssen, um, wenn überhaupt, ein prekäres psychobiologisches und psychosoziales Gleichgewicht aufrechterhalten zu können. Dem nicht zu bezweifelnden Nutzen einer neuroleptischen Medikation steht eine Reihe bedeutsamer Nebenwirkungen gegenüber, die prinzipiell das subjektive Erleben und soziale Handeln des betroffenen Patienten empfindlich beeinträchtigen können. Eine neuroleptische Therapie, besonders als Langzeitmedikation, setzt also immer eine differenzierte Nutzen-Risiko-Rechnung für den individuellen Patienten voraus.
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Literatur
Aaes-Jorgensen T, Kirk L, Petersen E, Danneskiold-Samsoe P, Jörgensen A (1983) Serum concentrations of the isomers of clopenthixol and a metabolite in patients given cis(Z)- clopenthixol decanoate in viscoleo. Psychopharmacology 81: 68–72
Agrup-Andersson L, Bengtsson A, Erlandsson K, Gottfries DG, Witzel-Östlund TG (1974) Flupenthixol decanoate - controlled investigation concerning dosage. Acta Psychiatr Scand [Suppl] 255: 7–14
Altamura AC, Whelpton R, Curry SH (1979) Animal model for investigation for fluphenazine kinetics after administration of long-acting esters. Biopharm Drug Dispos 1: 65–72
Baldessarini RJ, Cohen BM, Teicher MH (1988) Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses. Arch Gen Psychiatry 45: 79–91
Beresford R, Ward A (1987) Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 33: 31–49
Bleuler M (1972) Die schizophrenen Geistesstörungen im Lichte langjähriger Kranken- und Familiengeschichten. Thieme, Stuttgart
Ciompi L, Müller C (1976) Lebensweg und Alter der Schizophrenen. Eine katamnestische Langzeitstudie bis ins Senium. Springer, Berlin Heidelberg New York
Curry SH (1977) Fluphenazin- und Fluphenazindecanoat-Plasmaspiegel beim Menschen. In: Kryspin-Exner K, Hinterhuber H, Haase H-J (Hrsg) Klinik und Pharmakologie der Lang- zeitneuroleptika. Schattauer, Stuttgart
Curry SH, Whelpton R, de Schepper PJ, Vranckx S, Schiff AA (1979) Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man. Br J Clin Pharmacol 7: 325–331
Dahl S (1988) Pharmakokinetik der Neuroleptika. Internationales Thioxanthen-Kolloquium, Hamburg, Nov 24–27
Deberdt R, Elens P, Berghmans W, Heykants J, Woestenborghs R, Dreisens F, Reyntijens A, Wijingaarden I (1980) Intramuscular haloperidol decanoate for neuroleptic maintenance therapy, efficacy, dosage schedule and plasma levels. Acta Psychiatr Scand 62: 356–363
DeCuyper H, Bollen J, van Praag HM, Verstraeten D (1986) Pharmacokinetics and therapeutic efficacy of haloperidol decanoate after loading dose administration. Br J Psychiatry 148: 560–566
Dencker SJ, Lepp M, Malm U (1980) Clopenthixol and flupenthixol depot preparations in out-patient schizophrenics I. A one year double-blind study of clopenthixol decanoate and flupenthixol palmitate. Acta Psychiatr Scand 61 [Suppl 279]: 10–28
Dudley J, Rauw G, Hawes EM, Keegan DL, Midha KK (1983) Correlation of fluphenazine plasma levels versus clinical response in patients: A pilot study. Prog Neuropsychopharmacol Biol Psychiatry 7: 791–795
Dysken MW, Javaid JI, Chang SS, Schaffer C, Shahid A, Davis JM (1981) Fluphenazine pharmacokinetics and clinical response. Psychopharmacology 73: 205–210
Eben E, Rüther E, Konstanzer A (1984) Psychopathological and neuroendocrinological parameters during long-term treatment with bromperidol decanoate. 14th CINP Congress, Florence
El-Assra A, El-Sobky A, Kaye N, Blain PG, Wiles DH, Hajioff J, Gould SE (1983) The change from oral to depot neuroleptics in chronic schizophrenia. Clinical response and plasma levels after treatment with bromperidol or fluphenazine decanoate. Janssen Res Rep
Ereshefsky L, Saklad SR, Jann MW, Davis CM, Richards A, Seidel DR (1984) Future of depot neuroleptic therapy: pharmacokinetic and pharmacodynamic approaches. J Clin Psychiatry [Sec 2] 45 (2): 50–59
Escobar JI, Barron A, Kiriakos R (1983) Serum levels of fluphenazine: Effect of dosage and route of administration and relations to side effects and clinical response. Psychopharmacol Bull 19: 131–133
Forsman A, Öhman R (1977) Applied pharmacokinetics of haloperidol in man. Curr Ther Res 21: 396–411
Gelders YG, Reyntijens AJM, Ash CW, Aerts TJL (1982) 12-months study of haloperidol decanoate in chronic schizophrenic patients. Int Pharmacopsychiatry 17: 247–254
Girard M, Granter F, Schmitt L, Cotonat J, Escande M, Blanc M (1984) Premiers résultats d’une étude pharmacoeinétique de la pipothiazine et de son ester palmitique (Piportil L4) dans une population de schizphrènes. Encephale 10: 171–176
Goldstein MJ, Rodnick EH, Evans JR, May PRA, Steinberg MR (1978) Drug and family therapy in the after care treatment of acute schizophrenics. Arch Gen Psychiatry 35: 1169–1177
Helmchen H (1978) Forschungsaufgaben bei psychiatrischer Langzeitmedikation. Nervenarzt 49: 534–538
Heykants J (1978) On the pharmacokinetics of haloperidol, pimozide and penfluridol. Symposium on Modern trends in psychopharmacology and psychiatry, Kollekolle, Denmark, Sept 22–23
Hogarty GE (1984) Depot neuroleptics: The relevance of psychosocial factors. J Clin Psychiatry [Sec 2] 45 (5): 34–42
Hollister LE (1983) Clinical pharmacology of psychotherapeutic drugs, 2nd edn. Churchill- Livingstone, New York
Hollister LE, Kim DY (1982) Intensive treatment with haloperidol of treatment-resistant chronic schizophrenic patients. Am J Psychiatry 139: 1466–1468
Huber G, Gross G, Schüttler R (1979) Schizophrenie. Eine Verlaufs- und sozialpsychiatrische Langzeitstudie. Springer, Berlin Heidelberg New York
Hyttel J (1982) Preferential labelling of adenylate cyclase coupled dopamin receptors with thioxanthene neuroleptics. In: Konsaka M et al. (eds) Advances in the bioscience. Pergamon, Oxford New York
Jain AK, Kelwala S, Gershon S (1988) Antipsychotic drugs in schizophrenia: current issues. Int Clin Psychopharmacol 3: 1–30
Jann MW, Ereshefsky L, Sakland SR (1985) Clinical pharmacokinetics of the depot antipsychotics. Clin Pharmacokinet 10: 315–333
Johnson DAW (1975) Observations on the dose regime of fluphenazine decanoate in maintenance therapy of schizophrenia. Br J Psychiatry 126: 457–461
Johnson DAW, Pasterski G, Ludlow JM, Street K, Taylor RDW (1983) The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic patients: drug and social consequences. Acta Psychiatr Scand 67: 339–352
Jorgensen A (1986) Metabolism and pharmacokinetics of antipsychotic drugs. Prog Drug Metab 9: 111–174
Jorgensen A, Overo KF (1980) Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III. Serum levels. Acta Psychiatr Scand 61 [Suppl 279]: 41–54
Jorgensen A, Andersen J, Bjorndal N, Dencker SJ, Lundin L, Malm U (1982) Serum concentrations of eis (Z)-flupenthixol and prolactin in chronic schizophrenic patients, treated with flupenthixol and eis ( Z)-flupenthixol decanoate. Psychopharmacology 77: 58–65
Kane JM (1987) Neuroleptic treatment of schizophrenia. In: Henn FA, DeLisi (eds) Handbook of schizophrenia, vol 2: Neurochemistry and neuropharmacology of schizophrenia. Elsevier, Amsterdam
Kane JM, Rifkin A, Woerner M, Reardon G, Sarantakos S, Schiebel D, Ramos-Lorenzi JR (1983) Low dose neuroleptic treatment of outpatient schizophrenics. I. Preliminary results of relapse rates. Arch Gen Psychiatry 40: 893–896
Kapfhammer HP, Rüther E (1987) Depotneuroleptika. Springer, Berlin Heidelberg New York London Paris Tokyo
Kissling W, Möller HJ, Walter K, Wittmann B, Krueger R, Trenk D (1985) Double-blind comparison of haloperidol decanoate and fluphenazine decanoate: effectiveness, side-effects, dosage and serum levels during a six months treatment for relapse prevention. Pharmaco-psychiatry 18: 240–245
Knudsen P (1985) Chemotherapy with neuroleptics. Clinical and pharmacokinetic aspects with a particular view to depot preparations. Acta Psychiatr Scand 72 [Suppl 322]: 51–75
Knudsen P, Hansen LB, Larsen AE (1985) Depot neuroleptic treatment: clinical and pharmacokinetic studies of perphenazine decanoate. Acta Psychiatr Scand 72 [Suppl 322): 5–50
Kuß HJ (1986) Pharmakokinetik der Depotneuroleptika. In: Das ärztliche Gespräch, Bd40. Tropon, Köln
Levine J, Schooler NR, Severe J et al. (1980) Discontinuation of oral and depot neuroleptic fluphenazine in schizophrenic patients after one year of continuous medication: a controlled study. In: Cattabeni F, Raccagni G, Spano PF et al. (eds) Long-term effects of neuroleptics. Raven, New York
Leysen JE, Niemegeers CJE (1985) Neuroleptics. In: Lajtha A (ed) Handbook of neurochemistry, vol 9. Plenum, New York, pp 331–361
Linde OK (1983) Neuroleptika auf Esterbasis. Krankenhauspharmazie 1: 36–40.
Lingjoerde O (1973) Some pharmacological aspects of depot neuroleptics. Acta Psychiatr Scand [Suppl] 246: 9–14
Magliozzi JR, Hollister LE, Arnold KV et al. (1981) Relationship of serum haloperidol levels to clinical response in schizophrenic patients. Am J Psychiatry 138: 365–367
Marder SR, Putten T van, Mintz J, Lebell M, McKenzie J, Galtico G (1984) Maintenance therapy. New findings. In: Kane JM (ed) Drug maintenance strategies in schizophrenia. APA, Washington
Marder SR, Hawes EM, Putten T van, Hubbard JW, McKay G, Mintz J, May PRA, Midha KK (1986) Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate. Psychopharmacology 88: 480–483
Mason AS, Granacher RP (1980) Clinical handbook of antipsychotic drug therapy. Brunner/Mazel, New York
Mavroidis ML, Kanter DR, Hirschowitz J, Garver DL (1983) Clinical response and plasma haloperidol levels in schizophrenia. Psychopharmaeology 81: 354–356
Mavroidis ML, Kanter DR, Hirschowitz J, Garver DL (1984 a) Therapeutic blood levels of fluphenazine or RBC determinations. Psychopharmacol Bull 20: 168–170
Mavroidis ML, Kanter DR, Hirschowitz J et al. (1984 b) Clinical relevance of thioxanthene plasma levels. J Clin Psychopharmacol 4: 155–157
McCreadie RG, Makie M, Wiles DH, Jorgensen A, Hansen V, Menzies C (1984) Within- individual variation in steady state plasma levels of different neuroleptics and prolactin. Br J Psychiatry 144: 625–629
Meco G, Casacchia M, Attenni M, Iafrate A, Castellana F, Ecarill (1983) Haloperidol decanoate in schizophreniform disorders. Acta Psychiatr Belg 83: 57–68
Midha KK, Hawes EM, Hubbard JW, Korchinski ED, McKay G (1987) The search for correlations between neuroleptic plasma levels and clinical outcome: a critical review. In: Meitzer H (ed) Psychopharmacology. The third generation of progress. Raven, New York
Miller DD, Hershey LA, Duffy JP et al. (1984) Serum haloperidol concentrations and clinical response in acute psychosis. J Clin Psychopharmacol 4: 305–310
Perris C (1976) Indications for long-term pharmacological treatment of schizophrenic syndromes. Pharmacopsychiatry 9: 146–159
Putten T van, May PRA, Marder SR, Wittmann LA (1981) Subjective response to antipsychotic drugs. Arch Gen Psychiatry 38: 187–190
Richelson E (1984) Neuroleptic affinities for human brain receptors and their use in predicting adverse effects. J Clin Psychiatry 45: 331–336
Saikia JK, Jorgensen A (1983) Steady–state serum concentrations after eis ( Z)-flupenthixol decanoate in viscoleo. Psychopharmacology 8: 371–373
Schindler R (1986) Früheinstellung auf Depotneuroleptika. In: Das ärztliche Gespräch, Bd 40. Tropon, Köln
Sieberns S (1986) Darstellung der Depotneuroleptika. In: Das ärztliche Gespräch, Bd 40. Tropon, Köln
Steiner S (1984) Modell V III. Konzept und Verwirklichung einer neuroleptischen Intensivbehandlung bei schizophrenen Patienten. Facultas, Wien
Szukalski B, Lipska B, Welbel L, Nurowska K (1986) Serum levels and clinical response in long-term pharmacotherapy with zuclopenthixol decanoate. Psychopharmacology 89: 428–431
Tune LE, Creese I, De Paulo JR, Slavney PR, Snyder SH (1981) Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients. H Nerv MentDis 169: 60–63
Viala A, Hou N, Ba B, Durand A, Dufour H, Agostino ND, Berda C, Jorgensen A (1984) Blood plasma kinetics of eis ( Z)-clopenthixol and fluphenazine in psychiatric patients after in-tramuscular injection of their decanoic esters. Psychopharmacology 83: 147-150
Wielink PS van (1987) The clinical pharmacology of depot neuroleptics. Janssen Res Rep
Wistedt B, Jorgensen A, Wiles DH (1982) A depot neuroleptic withdrawal study. Plasma concentrations of fluphenazine and flupenthixol and relapse frequency. Psychopharmacology 78: 301–304
Yadalam KG, Simpson GM (1988) Changing from oral to depot fluphenazine. J Clin Psychiatry 49: 346–348
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Kapfhammer, HP. (1990). Umstellungsregime von Kurzzeit- auf Depotneuroleptika. In: Müller-Oerlinghausen, B., Möller, HJ., Rüther, E. (eds) Thioxanthene. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75194-3_18
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