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Umstellungsregime von Kurzzeit- auf Depotneuroleptika

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Thioxanthene

Zusammenfassung

Neuroleptika besitzen ihre Domäne in der Behandlung produktiver Psychosen. Sie sind speziell in der Therapie der schizophrenen Erkrankungen unverzichtbar. Zahlreiche Langzeituntersuchungen zum Verlauf der schizophrenen Psychosen dokumentieren einerseits eine bunte Vielfalt der Verlaufsgestalten, sprechen also klar gegen einen monolithischen und progredienten Krankheitsprozeß (Bleuler 1972; Ciompi u. Müller 1976; Huber et al. 1979). Sie zeigen aber andererseits auch, daß ca. 2/3 der einmal an einer schizophrenen Psychose erkrankten Patienten wiederholt längerfristig oder auch dauernd Neuroleptika einnehmen müssen, um, wenn überhaupt, ein prekäres psychobiologisches und psychosoziales Gleichgewicht aufrechterhalten zu können. Dem nicht zu bezweifelnden Nutzen einer neuroleptischen Medikation steht eine Reihe bedeutsamer Nebenwirkungen gegenüber, die prinzipiell das subjektive Erleben und soziale Handeln des betroffenen Patienten empfindlich beeinträchtigen können. Eine neuroleptische Therapie, besonders als Langzeitmedikation, setzt also immer eine differenzierte Nutzen-Risiko-Rechnung für den individuellen Patienten voraus.

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Kapfhammer, HP. (1990). Umstellungsregime von Kurzzeit- auf Depotneuroleptika. In: Müller-Oerlinghausen, B., Möller, HJ., Rüther, E. (eds) Thioxanthene. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75194-3_18

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