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The Epidermal Growth Factor Receptor: Receptor Dimerization and Signal Transduction

  • Gijs F. Verheijden
  • Ingrid Verlaan
  • Wouter H. Moolenaar
Conference paper
Part of the NATO ASI Series book series (volume 52)

Abstract

The epidermal growth factor (EGF) receptor is a single chain transmembrane glycoprotein with ligand-dependent protein tyrosine kinase activity (Carpenter, 1987). Activation of the receptor tyrosine kinase is essential, although not necessarily sufficient, for the multiple biological effects of EGF (Chen et al., 1987; Moolenaar et al.,1988). Early events induced by EGF include tyrosine-specific protein phosphorylations, inositol lipid breakdown, changes in cytoplasmic pH and free Ca2+ and alterations in membrane potential (Carpenter, 1987; Chen et al, 1987; Moolenaar et al, 1986 and 1988; Rothenberg et al, 1982; Tilly et al., 1988; Pandiella et al., 1989). This chapter briefly summarizes our recent findings on two aspects of EGF receptor function: ligand-dependent receptor activation with emphasis on the proposed role of ‘receptor dimerization’ and post-receptor signal transduction, particularly the activation of phosphoinositide-specific phospholipase C.

Keywords

Epidermal Growth Factor Receptor Epidermal Growth Factor A431 Cell Human Epidermal Growth Factor Receptor Receptor Tyrosine Kinase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Gijs F. Verheijden
    • 1
  • Ingrid Verlaan
    • 1
  • Wouter H. Moolenaar
    • 1
  1. 1.Division of Cellular BiochemistryThe Netherlands Cancer InstituteAmsterdamThe Netherlands

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