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Effect of Aging on the ß-Adrenergic Signal Transduction System in Rat Kidney, Lung, and Mononuclear Leukocytes

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Biological Signal Transduction

Part of the book series: NATO ASI Series ((ASIH,volume 52))

Abstract

Increasing evidence suggests that the process of aging is accompanied by, or results in, altered function of the adrenergic system (Pfeifer et al., 1982; Roberts and Turner, 1987). In this overview recent data on the effect of aging on the properties and the function of the ß-adrenergic signal transduction (ßAST) system in kidneys, lungs and mononuclear leukocytes will be discussed. Earlier results have been summarized before (Ebstein et al., 1985; Krall, 1985; Feldman, 1986), while the effect of aging on the ßAST system in the heart has been reviewed recently (Weiss et al., 1984; Nielson and Vestal, 1989).

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References

  • Abrass IB, Scarpace PJ (1981) Human lymphocyte beta-adrenergic receptors are unaltered with age. J Gerontol 36:298–301

    PubMed  CAS  Google Scholar 

  • Abrass IB, Scarpace PJ (1982) Catalytic unit of adenylate cyclase: reduced activity in aged-human lymphocytes. J Clin Endocrinol Metabol 55:1026–1028

    Article  CAS  Google Scholar 

  • Abrass IB, Davis JL, Scarpace PJ (1982) Isoproterenol responsiveness and myocardial ß-adrenergic receptors in young and old rats. J Gerontol 37:156–160

    PubMed  CAS  Google Scholar 

  • Anderson S, Brenner BM (1986) Effects of aging on the renal glomerulus. Am J Med 80:435–442

    Article  PubMed  CAS  Google Scholar 

  • Arch JRS, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thody VE, Wilson C, Wilson S (1984) Atypical ß-receptor on brown adipocytes as target for anti-obesity drugs. Nature 309:163–165

    Article  PubMed  CAS  Google Scholar 

  • Benovic JL, Stiles GL, Lefkowitz RJ, Caron MG (1983) Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity. Biochem Biophys Res Comm 110:504–511

    Article  PubMed  CAS  Google Scholar 

  • Birnbaumer L, Abramowitz J, Brown AM (1990) Receptor-effector coupling by G proteins. Biochim Biophys Acta 1031:163–224

    PubMed  CAS  Google Scholar 

  • Bjorksten J, Tenhu H (1990) The crosslinking theory of aging -added evidence. Expl Gerontol 25:91–95

    Article  CAS  Google Scholar 

  • Brodde O-E (1983) Endogenous and exogenous regulation of human α-and ß-adrenergic receptors. J Recept Res 3:151–162

    PubMed  CAS  Google Scholar 

  • Brodde O-E, Michel MC, Gordon EP, Sandoval A, Gilbert EM, Bristow MR (1989) ß-adrenoceptor regulation in the human heart: can it be monitored in circulating lymphocytes? Eur Heart J 10(suppl B):2–10

    PubMed  CAS  Google Scholar 

  • Casperson GF, Bourne HR (1987) Biochemical and molecular genetic analysis of hormone-sensitive adenylyl cyclase. Ann Rev Pharmacol Toxicol 27:371–384

    Article  CAS  Google Scholar 

  • Casey PF, Gilman AG (1988) G-protein involvement in receptor-effector coupling. J Biol Chem 263:2577–2580

    PubMed  CAS  Google Scholar 

  • Chabre M (1987) The G protein connection: is it in the membrane or the cytoplasm? TIBS 12:213–215

    CAS  Google Scholar 

  • Cavagnaro J, Waterhouse GAW, Lewis RM (1988) Neuroendocrine-immune interactions: immunoregulatory signals mediated by neurohumoral agents. In: The year in immunology, (Eds Cruse JM, Lewis RE, Jackson), Karger, Basel; Vol 3:228–246

    Google Scholar 

  • Doyle V, O’Malley K, Kelly JG (1982) Human lymphocyte ß-adrenoceptor density in relation to age and hypertension. J Cardiovasc Pharmacol 4:738–740

    Article  PubMed  CAS  Google Scholar 

  • Duncan PG, Douglas JS (1985) Age-related changes in guinea pig respiratory tissues: considerations for assessment of bronchodilators. Eur J Pharmacol 108:39–48

    Article  PubMed  CAS  Google Scholar 

  • Duncan PG, Brink C, Douglas JS (1982) ß-receptors during aging in respiratory tissues. Eur J Pharmacol 78:45–52

    Article  PubMed  CAS  Google Scholar 

  • Ebstein RP, Stessman J, Eliakim R, Menczel J (1985) The effect of age on ß-adrenergic function in man: a review. Isr J Med Sci 21:302–311

    PubMed  CAS  Google Scholar 

  • Emorine LJ, Marullo S, Briend-Sutren M-M, Patey G, Tate K, Delavier-Klutchko C, Strosberg D (1989) Molecular characterisation of the human ß3-adrenergic receptor. Science 245:1118–1121

    Article  PubMed  CAS  Google Scholar 

  • Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJJ (1984) Alterations in leukocyte ß-receptor affinity with aging. New Engl J Med 310:815–819

    Article  PubMed  CAS  Google Scholar 

  • Feldman RD (1986) Physiological and molecular correlates of age-related changes in the human ß-adrenergic receptor system. Fed Proc 45:48–50

    PubMed  CAS  Google Scholar 

  • Foresta P, Ramacci MT, Giuliani A, Angelucci L (1990) Aging and immune response: a multivariate approach. Expl Gerontol 25:117–126

    Article  CAS  Google Scholar 

  • Freissmuth M, Casey PJ, Gilman AG (1989) G proteins control diverse pathways of transmembrane signaling. FASEB J 3:2125–2131

    PubMed  CAS  Google Scholar 

  • Frielle T, Daniel KW, Caron MG, Lefkowitz RJ (1988) Structural basis of ß-adrenergic receptor subtype specificity studied with chimeric ß1/ß2-adrenergic receptors. Proc Natl Acad Sci 85:9494–9498

    Article  PubMed  CAS  Google Scholar 

  • Frossard N, Landry Y (1985) Physiological approach of beta receptor coupling to adenylate cyclase in rat airways: ontogenical modification and functional antagonism. J Pharmacol Expl Ther 233:168–175

    CAS  Google Scholar 

  • Galbusera M, Garattini S, Remuzzi G, Mennini T (1988) Catecholamine receptor binding in rat kidney: effect of aging. Kidney Internat 33:1073–1077

    Article  CAS  Google Scholar 

  • Geokas MC, Lakatta EG, Makinodan T, Timiras PS (1990) The aging Process. Ann Int Med 113:455–466

    PubMed  CAS  Google Scholar 

  • Gierschik P, Grandt R, Marquetant R, Jakobs KH (1987) Role of G-proteins in signal transduction. J Cardiovasc Pharmacol 10 (suppl 4):S6–S10

    CAS  Google Scholar 

  • Granneman JG (1990) Norepinephrine and BRL 37344 stimulate adenylate cyclase by different receptors in rat brown adipose tissue. J Pharmacol Expl Ther 254:508–513

    CAS  Google Scholar 

  • Halper JP, Mann JJ, Weksler ME, Bilezikian JP, Sweeney JA, Brown RP, Golbourne T (1984) Beta adrenergic receptors and cyclic AMP levels in intact human lymphocytes: effects of age and gender. Life Sci 35:855–863

    Article  PubMed  CAS  Google Scholar 

  • Hanski E, Rimon G, Levitzki A (1979) Adenylate cyclase activation by the ß-adrenergic receptors as a diffusion-controlled process. Biochem 18:846–853

    Article  CAS  Google Scholar 

  • Hayflick L (1985) Theories of biological aging. Expl Gerontol 20:145–159

    Article  CAS  Google Scholar 

  • Jones TLZ, Simonds WF, Merendino JJ, Brann MR, Spiegel AM (1990) Myristoylation of an inhibitory GTP-binding protein α-subunit is essential for its membrane attachment. Proc Natl Acad Sci USA 87:568–572

    Article  PubMed  CAS  Google Scholar 

  • Kaumann AJ (1989) Is there a third heart ß-adrenoceptor? TIPS 10:316–320

    PubMed  CAS  Google Scholar 

  • Kraft CA, Castleden CM (1981) The effect of aging on ß-adrenoceptor-stimulated cyclic AMP formation in human lymphocytes. Clin Sci 60:587–589

    PubMed  CAS  Google Scholar 

  • Krall JF, Connelly-Fittingoff M, Tuck ML (1983) Lymphocyte adenylate cyclase and human aging. Proc Soc Expl Biol Med 173:475–480

    CAS  Google Scholar 

  • Krall JF (1985) Aging: effect on the biochemistry of beta-adrenergic catecholamine action. Rev Clin Bas Pharmacol 5:159–174

    CAS  Google Scholar 

  • Krall JF, Fernandez EI, Connelly-Fittingoff M (1987) Human aging: effect on the activation of lymphocyte cyclic AMP-dependent protein kinase by Forskolin. Proc Soc Expl Biol Med 184:396–402

    CAS  Google Scholar 

  • Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597–598

    Article  PubMed  CAS  Google Scholar 

  • Landmann R, Bittiger H, Bühler FR (1981) High affinity beta-2-adrenergic receptors in mononuclear leukocytes: similar density in young and old normal subjects. Life Sci 29:1761–1771

    Article  PubMed  CAS  Google Scholar 

  • Landmann R, Bürgisser E, Bühler FR (1983) Human lymphocytes as a model for beta-adrenergic receptors in clinical investigation. J Recept Res 3:71–88

    PubMed  CAS  Google Scholar 

  • Levitzki A (1988) From epinephrine to cyclic AMP. Science 241:800–806

    Article  PubMed  CAS  Google Scholar 

  • Limbird LE (1981) Activation and attenuation of adenylate cyclase. Biochem J 195:1–13

    PubMed  CAS  Google Scholar 

  • Lockshin RA, Zakeri ZF (1990) Programmed cell death: new thoughts and relevance to aging. J Gerontol: Biol Sci 45:B135–140

    CAS  Google Scholar 

  • Mader SL, Davis PB (1989) Effect of age on acute regulation of beta-adrenergic responses in mononuclear leukocytes. J Gerontol 44:M168–173

    PubMed  CAS  Google Scholar 

  • Marinetti GV, Rosenfeld SI, Thiem PA, Condemi JJ, Leddy JP (1983) Beta-adrenergic receptors of human leukocytes. Biochem Pharmacol 31:2033–2043

    Article  Google Scholar 

  • Meites J, Goya Y, Takahashi S (1987) Why the neuroendocrine system is important in aging processes. Expl Gerontol 22:1–15

    Article  CAS  Google Scholar 

  • Meurs H, Van Den Bogaard W, Kauffman HF, Bruynzeel PLB (1982) Characterization of (-)-[3H]dihydroalprenolol binding to intact and broken cell preparations of human peripheral blood lymphocytes. Eur J Pharmacol 85:185–194

    Article  PubMed  CAS  Google Scholar 

  • Middeke M, Remien J, Holzgreve H (1984) The influence of sex, age, blood pressure and physical stress on ß2-adrenoceptor density of mononuclear cells. J Hypert 2:261–264

    CAS  Google Scholar 

  • Mumby SM, Heukeroth RO, Gordon JI, Gilman AG (1990) G-protein α-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci USA 87:728–732

    Article  PubMed  CAS  Google Scholar 

  • Nielson CP, Vestal RE (1989) α-adrenoceptors, ß-adrenoceptors and aging. In Handbook of Hypertension vol 12: Hypertension in the Elderly. Eds Amery A, Staessen J. Elsevier Sci

    Google Scholar 

  • Nokubo M (1985) Physical-chemical and biochemical differences in liver plasma membranes in aging F-344 rats. J Geront 40:409–414

    PubMed  CAS  Google Scholar 

  • O’Hara N, Daul, AE, Fesel R, Siekmann U, Brodde O-E (1985) Different mechanisms underlying reduced ß2-adrenoceptor responsiveness in lymphocytes from neonates and old subjects. Mech Ageing Devel 31:115–122

    Article  Google Scholar 

  • O’Donnell SR, Wanstall JC (1984) Beta-1 and beta-2 adrenoceptor-mediated responses in pulmonary artery and aorta from young and aged rats. J Pharmacol Expl Ther 228:733–738

    Google Scholar 

  • Oppenheim G, Mintzer J, Halperin Y, Eliakim R, Stessman J, Ebstein RP (1984) Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer’s disease. Life Sci 35:1795–1802

    Article  PubMed  CAS  Google Scholar 

  • Peters R (1988) Lateral mobility of proteins and lipids in the red cell membrane and the activation of adenylate cycclase by ß-adrenergic receptors. FEBS letters 234:1–7

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer MA, Weinberg CR, Cook D, Best JD, Reenan A, Halter JB (1983) Differential changes of autonomic nervous system function with age in man. Am J Med 75:249–258

    Article  PubMed  CAS  Google Scholar 

  • Raymond JR, Hnatowich M, Lefkowitz RJ, Caron MG (1990) Adrenergic receptors. Models for regulation of signal transduction processes. Hypert 15:119–131

    CAS  Google Scholar 

  • Roa KM, Cohen HJ (1990) The role of the cytoskeleton in aging. Expl Geront 24:7–22.

    Google Scholar 

  • Roberts J, Tumer N (1987) Age-related changes in autonomic function of catecholamines. Rev Biol Res Aging 3:257–298

    CAS  Google Scholar 

  • Sandnes D, Jacobsen FW, Jacobsen S (1987) Modes of determining ß-adrenoceptor number in human mononuclear leukocytes. Pharmacol Toxicol 61:265–270

    Article  PubMed  CAS  Google Scholar 

  • Scarpace PJ, Yu PB (1987) Diet restriction retards the age-related loss of beta-adrenergic receptors and adenylate cyclase activity in rat lung. J Gerontol 42:442–446

    PubMed  CAS  Google Scholar 

  • Scarpace PJ, Baresi LA (1988) Increased beta-adrenergic receptors in the light-density membrane fraction in lungs from senescent rats. J Gerontol 43:B163–167

    PubMed  CAS  Google Scholar 

  • Scarpace PJ, Abrass IB (1983) Decreased beta-adrenergic agonist affinity and adenylate cyclase activity in senescent rat lung. J Gerontol 38:143–147

    PubMed  CAS  Google Scholar 

  • Schocken DD, Roth GS (1977) Reduced beta-adrenergic receptor concentrations in ageing man. Nature 267:856–859

    Article  PubMed  CAS  Google Scholar 

  • Stiles GL, Strasser RH, Kilpatrick BF, Taylor SR, Lefkowitz RJ (1984) Endogenous proteinases modulate the function of the ß-adrenergic receptor-adenylate cyclase system. Biochim Biophys Acta 802:390–398

    Article  PubMed  CAS  Google Scholar 

  • Strosberg AD (1987) Molecular and functional properties of beta-adrenergic receptors. Am J Cardiol 59:3F–9F

    Article  PubMed  CAS  Google Scholar 

  • Vanscheeuwyck P, Fraeyman N (1989a) Evaluation of a semiautomatic cell harvester filtration for the determination of ß-adrenoceptors in human mononuclear leukocytes. J Pharmac Methods 21:299–307

    Article  Google Scholar 

  • Vanscheeuwijck P, Van de Velde E, Fraeyman N (1989b) Effect of aging on properties and function of ß-adrenoceptors in rat lung. Eur J Pharmacol (Mol Pharmacol Sect) 172:373–380

    Article  CAS  Google Scholar 

  • Vanscheeuwijck P, Van de Velde E, Fraeyman N (1990a) The ß-adrenergic transduction system in kidneys from young and senescent rats. Eur J Pharmacol (Mol Pharmacol Sect) 188:129–137

    Article  CAS  Google Scholar 

  • Vanscheeuwijck P, Van de Velde E, Fraeyman N (1990b) Characterization of the ß-adrenergic transduction system in spleen mononuclear leukocyte membranes of young and senescent rats. Biochem Pharamcol 39:2035–2040

    Article  CAS  Google Scholar 

  • Vega JA, Ricci A, Amenta F (1990) Age-dependent changes of the sympathetic innervation of the rat kidney. Mech Ageing Devel 54:185–196

    Article  CAS  Google Scholar 

  • Weiss B, Clarck MB, Greenberg LH (1984) Modulation of catecholaminergic receptors during development and aging in Handbook of Neurochemistry, vol 6: receptors in the nervous system; Ed Lajtha, Plenum Press

    Google Scholar 

  • Williams LT, Snyderman R, Lefkowitz RJ (1976) Identification of ß-adrenergic receptors in human lymphocytes by (-)[3H]alprenolol binding. J Clin Invest 57:149–157

    Article  PubMed  CAS  Google Scholar 

  • Yamamura HI, Enna SJ, Kuhar MJ (Eds) (1990) Methods in neurotransmitter receptor analysis. Raven Press New York

    Google Scholar 

  • Zahniser NR, Parker DC, Bier-Laning CM, Miller JA, Gerber JG, Nies AS (1988) Comparison between the effects of aging on antagonist and agonist interactions with beta-adrenergic receptors on human mononuclear and polymorphonuclear leukocyte membranes. J Gerontol 43:M151–157.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Heymans Institute of Pharmacology, De Pintelaan 185, B-9000, Ghent, Belgium

    N. Fraeyman, E. Van de Velde & P. Vanscheeuwijck

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  1. N. Fraeyman
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  2. E. Van de Velde
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  3. P. Vanscheeuwijck
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Editors and Affiliations

  1. Dept. of Pharmacology, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9041, USA

    Elliott M. Ross

  2. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1991 Springer-Verlag Berlin Heidelberg

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Fraeyman, N., Van de Velde, E., Vanscheeuwijck, P. (1991). Effect of Aging on the ß-Adrenergic Signal Transduction System in Rat Kidney, Lung, and Mononuclear Leukocytes. In: Ross, E.M., Wirtz, K.W.A. (eds) Biological Signal Transduction. NATO ASI Series, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75136-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-75136-3_14

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