Effect of Aging on the ß-Adrenergic Signal Transduction System in Rat Kidney, Lung, and Mononuclear Leukocytes

  • N. Fraeyman
  • E. Van de Velde
  • P. Vanscheeuwijck
Part of the NATO ASI Series book series (volume 52)


Increasing evidence suggests that the process of aging is accompanied by, or results in, altered function of the adrenergic system (Pfeifer et al., 1982; Roberts and Turner, 1987). In this overview recent data on the effect of aging on the properties and the function of the ß-adrenergic signal transduction (ßAST) system in kidneys, lungs and mononuclear leukocytes will be discussed. Earlier results have been summarized before (Ebstein et al., 1985; Krall, 1985; Feldman, 1986), while the effect of aging on the ßAST system in the heart has been reviewed recently (Weiss et al., 1984; Nielson and Vestal, 1989).


Adenylate Cyclase Receptor Density Mononuclear Leukocyte Splenic Leukocyte Isoproterenol Stimulation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • N. Fraeyman
    • 1
  • E. Van de Velde
    • 1
  • P. Vanscheeuwijck
    • 1
  1. 1.Heymans Institute of PharmacologyGhentBelgium

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