Cells and Immune Processes Contributing to Pancreatic Islet Inflammation

  • H. Kolb
  • V. Kolb-Bachofen
Conference paper
Part of the NATO ASI Series book series (volume 38)

Abstract

Macrophages precede lymphocytic infiltration of pancreatic islets during the development of insulin dependent diabetes in BB rats. Concomitant with macrophage invasion, local hyperexpression of class I MHC antigens and vascular defects are seen in afflicted islets. A macrophage produce, TNF, was shown to enhance transcription and cell surface expression of class I MHC antigens on rat insulinoma cells. Another monokine, interleukin 1 beta, was found to be a potent inducer of vascular permeability increase. Thus macrophages may be responsible for early lesions seen in inflamed islets.

Keywords

Permeability Acetone Interferon Cyclosporin Ox17 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Kolb
    • 1
  • V. Kolb-Bachofen
    • 1
  1. 1.Diabetes Research Institute and Institute for Biophysics and Electron MicroscopyUniversity of DüsseldorfDüsseldorf 1Fed. Rep. Germany

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