On the Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis
The nicotinic acetylcholine receptor (AChR) from mammalian muscle and fish electric organ consists of four homologous subunits with the stoichiometry a2βγδ. Each subunit transverses the membrane at least four times (Changeux and Revan, 1987; Numa et al., 1983). The AChR molecule is the major autoantigen in the human autoimmune disease, myasthenia gravis (MG) (Willcox and Vincent, 1988). Anti-AChR antibodies result in loss of AChRs and also directly block the function of the remaining AChR molecules, thereby causing a defect in neuromuscular transmission.
KeywordsAcetylcholine Receptor Nicotinic Acetylcholine Receptor TE671 Cell Antigenic Modulation Cell Line TE671
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