Determination of Plasma Volume by Indocyanine Green

  • H. Schad
  • M. Haider
  • H. Brechtelsbauer
  • A. Bernhard-Abt
Conference paper


The knowledge of the actual plasma volume is important in the treatment of patients, as well as in clinical research and in experimental studies. The determination is usually performed by the indicator dilution technique with Evans blue, which had been introduced already in the thirties by Gibson and Evans [13] and Gregersen and coworkers [16]. This method, however, is rather time consuming and the number of determinations is limited due to the rather slow elimination of the dye from the circulation and the resulting increase in “background”. Some years ago, the use of radioiodinated albumin was propagated, but this indicator has become obsolete. The advantages of radioalbumin are small, as compared to Evans blue, repetitive determinations are also limited due to the accumulating “background”, but patients are exposed to radiation, and the use of radioactivity should be limited to the indispensable minimum.


Plasma Volume Indocyanine Green Evans Blue Disappearance Rate Indicator Dilution Technique 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Schad
  • M. Haider
  • H. Brechtelsbauer
  • A. Bernhard-Abt

There are no affiliations available

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