Long-Term Modulation of Hypothalamic Neurons by Neuropeptides
Concepts of neuronal integration of peripheral and central temperature signals are based on the assumption that specific warm- and cold-sensitive neurons in the preoptic and anterior hypothalamic area and ascending fibres of the afferent warm and cold pathway converge onto integrative neurons, which in turn transfer the integrated signal to neurons which are insensitive to local temperature changes (Hammel 1968; Bligh 1979). In these models it is inherent that a particular neuron is either sensitive or insensitive to temperature changes, and that temperaturesensitive neurons are either warm- or cold-sensitive. However, a temperature dependence of signal processing in integrative neuronal networks of the hypothalamus has also been considered (Simon 1981). In addition, it has been observed that after blockade of synaptic transmission, some warm-sensitive neurons were converted to cold-sensitive ones and vice versa, suggesting that the temperature characteristic depends to a great extent on the variable synaptic input (Pierau and Nakashima 1986).
KeywordsDopamine Lysine Catecholamine Milton Vale
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