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Interventionstherapiestudien bei HIV-Infektion

  • Conference paper
19. Hämophilie-Symposion Hamburg 1988

  • 18 Accesses

Zusammenfassung

Zunächst stellt sich die Frage, welche Eigenschaften eine ideale antiretrovirale Substanz aufweisen müßte. Die Antworten klingen einfach. Folgendes müßte gewährleistet sein: Eine effektive Hemmung der Virusreplikation, nicht nur in vitro, sondern auch in vivo; eine Toxizität, die auch in einer Langzeittherapie nicht limitierend ist; eine maximale therapeutische Breite; Fehlen von Resistenzentwicklung; günstige pharmakokinetische Eigenschaften bezüglich Passage der Blut-Hirn-Schranke, Plasmahalbwertszeit und Bioverfügbarkeit bei oraler Applikation. Nicht zuletzt ist hinsichtlich des Langzeiteinsatzes idealerweise eine kostengünstige Substanz wünschenswert [1].

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Author information

Authors and Affiliations

  1. München, Deutschland

    J. R. Bogner, A. Matuschke, B. Heinrich, H. S. Füessl & F.-D. Goebel

Authors
  1. J. R. Bogner
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  2. A. Matuschke
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  3. B. Heinrich
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  4. H. S. Füessl
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  5. F.-D. Goebel
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Editor information

Editors and Affiliations

  1. Abteilung Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Deutschland

    G. Landbeck

  2. 8000, München, Deutschland

    R. Marx

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© 1989 Springer-Verlag Berlin Heidelberg

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Bogner, J.R., Matuschke, A., Heinrich, B., Füessl, H.S., Goebel, FD. (1989). Interventionstherapiestudien bei HIV-Infektion. In: Landbeck, G., Marx, R. (eds) 19. Hämophilie-Symposion Hamburg 1988. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75053-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-75053-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51667-5

  • Online ISBN: 978-3-642-75053-3

  • eBook Packages: Springer Book Archive

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