Advertisement

Clustered Arrangement and Interaction of Steroid Hormone Receptors with Other Transcription Factors

  • R. Renkawitz
  • R. Schüle
  • C. Kaltschmidt
  • C. Baniahmad
  • A. Baniahmad
  • J. Altschmied
  • Ch. Steiner
  • M. Muller
Conference paper
Part of the 40. Colloquium der Gesellschaft für Biologische Chemie 6.– 8. April 1989 in Mosbach/Baden book series (MOSBACH, volume 40)

Abstract

One of the main contemporary challenges in molecular genetics is the elucidation of the mechanisms underlying gene regulation. Several tissue-specific promoter or enhancer elements have been identified. Many of the model systems analyzed are limited in that only mature cells or tissues are available for testing, whereas gene regulation may occur in a multistep process during differentiation from precursor to mature cells and may be modulated at certain levels of differentiation by different hormones. The hematopoetic cell population is generated by one of the few differentiation pathways which can be studied step by step in vitro as well as in vivo. Expression of the lysozyme gene is a specific differentiation marker, being gradually turned on during maturation of macrophages. In addition to this constitutive macrophage expression, the chicken lysozyme gene is inducible by steroid hormones in the tubular gland cells of the oviduct.

Keywords

Enhancer Element Receptor Binding Site Chloramphenicol Acetyl Transferase Lysozyme Gene Chloramphenicol Acetyl Transferase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baniahmad, A., Muller, M., Steiner, Ch. & Renkawitz, R. (1987) EMBO J. 6: 2297–2303PubMedGoogle Scholar
  2. Barrera-Saldana, H., Takahashi, K., Vigneron, M., Wildeman, A., Davidson, I. & Chambon, P. (1985) EMBO J. 4: 3839–3849PubMedGoogle Scholar
  3. Bird, A.P. (1984) Nature (London) 307: 503–504CrossRefGoogle Scholar
  4. Cato, A.C.B., Skroch, P., Weinmann, J., Butkeraitis, P. & Ponta, H. (1988) EMBO J. 7:1403–1408 Chodosh, L.A., Baldwin, A.S., Carthew, R.W. & Sharp, P.A. (1988) Cell 53: 11–19Google Scholar
  5. Danesch, U., Gloss, B., Schmid, W., Schutz, G., Schäle, R. & Renkawitz, R. (1987) EMBO J. 6:625–630 Hecht, A., Berkenstam, A., Stromstedt, P-E., Gustafsson, J.-A. & Sippel, A.E. (1988) EMBO J. 7:2063–2073 Lee, W., Haslinger, A., Karin, M. & Tjian, R. (1987) Nature (London) 325: 368–372Google Scholar
  6. Miksicek, R., Borgmeyer, U. & Nowock, J. (1987) EMBO J. 6: 1355–1360PubMedGoogle Scholar
  7. Payvar, F., DeFranco, D., Firestone, G.L., Edgar, B., Wrange, O., Okret, S., Gustafsson, J.-,4. & Yamamoto, K.R. (1983) Cell 356: 381–392CrossRefGoogle Scholar
  8. Renkawitz, R., Schutz, G., von der Ahe, D. & Beato, M. (1984) Cell 37: 503–510PubMedCrossRefGoogle Scholar
  9. Rosales, R., Vigneron, M., Macchi, M., Davidson, I., Xiao, J.H. & Chambon, P. (1987). EMBO J. 6: 3015–3025PubMedGoogle Scholar
  10. Scheidereit, C., Geisse, S., Westphal, H.M. & Beato, M. (1983) Nature (London) 304:749–752 Schule, R., Muller, M., Otsuka-Murakami, H. & Renkawitz, R. (1988a) Nature (London) 332:87–90 Schüle, R., Muller, M., Kaltschmidt, C. & Renkawitz, R. (1988b) Science 242: 1418–1420Google Scholar
  11. Speck, N.A. & Baltimore, D. (1987) Mol. Cell. Biol. 7: 1101–1110Google Scholar
  12. Steiner, Ch., Muller, M., Baniahmad, A. & Renkawitz, R. (1987) Nucl. Acids Res. 15:4163–4177 Strähle, U., Klock, G. & Schutz, G. (1987) Proc. Natl. Acad. Sci. USA 84: 7871–7875Google Scholar
  13. Takahashi, K., Vigneron, M., Matthes, H., Wildeman, A., Zenke, M. & Chambon, P. (1986) Nature (London) 319: 121–126CrossRefGoogle Scholar
  14. von der Ahe, D., Janich, S., Scheidereit, C., Renkawitz, R., Schutz, G. & Beato, M. (1985) Nature (London) 313: 706–709CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. Renkawitz
    • 1
  • R. Schüle
    • 1
    • 2
  • C. Kaltschmidt
    • 1
  • C. Baniahmad
    • 1
  • A. Baniahmad
    • 1
  • J. Altschmied
    • 1
    • 2
  • Ch. Steiner
    • 1
  • M. Muller
    • 1
  1. 1.Max-Planck-Institut für BiochemieGenzentrumMartinsriedFed. Rep. of Germany
  2. 2.Salk Institute for Biological StudiesLa JollaUSA

Personalised recommendations