Abstract
The specific goal of tissue characterization using an imaging technique is the possibility of distinguishing in the image between a lesion and adjacent normal tissues, between benign and malignant neoplasias, and between primary tumors and metastases using special analysis procedures. The final objective is to improve diagnosis and prognosis and optimize therapy planning. Intrinsic multiparameter dependece is a peculiarity of magnetic resonance imaging (MRI), which provides both high tissue contrast flexibility and a possible special source of in vivo tissue characterization. A primary role in the expression of these features is played by MR spin-lattice and spin-spin relaxation times of tissues in the body.
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References
Abragam A (1961) The principles of nuclear magnetism. Clarendon, Oxford
Beall PT, Sharad RA, Sitapati RK (1984) NMR data handbook for biomedical applications. Pergamon, New York
Beneken JEW, Brown BH, Skupinski W (1985) Biomedical engineering programme of the European Community. J Med Eng Technol 9:61–68
Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM (1984) A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1–100 MHz: dependence of tissue type, NMR frequency, temperature, species, excision and age. Med Phys 11:425–448
Bottomley PA, Hardy CJ, Argensinger RE, Allen-Moore G (1987) A review of H nuclear magnetic resonance relaxation in pathology: are T1 and T2 diagnostic? Med Phys 14:1–37
Bydder GM (1987) Clinical use of contrast agents. In: Foster MA, Hutchison JMS. (eds) Practical NMR imaging. IRL Press, Washington, DC, pp 173–198
Damadian R (1971) Tumor detection by NMR. Science 171:1151–1153
EEC Concerted Research Project (1988a) Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. II. A protocol for in vitro proton rexalation studies. Magn Reson Imaging 6:179–184
EEC Concerted Research Project (1988b) Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. IV. Protocol and test objects for the assessment of MRI equipment. Magn Reson Imaging 6:195–199
Lerski RA, Orr JS (1987) Practical testing. In: Foster MA, Hutchison JMS. (eds) Practical NMR imaging. IRL, Press Washington, DC, pp 81–93
Lerski RA, McRobbie DW, Straughan K, Walker PM, de Certaines JD, Bernard AM (1988) Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. V. Multi-center trial with protocols and prototype test objects for the assessment of MRI equipment. Magn Reson Imaging 6:201–214
Mathur-De Vré R (1984) Biomedical implications of the relaxation behaviour of water related to NMR imaging. Br J Radiol 57:955–976
Mathur-De Vré R, Binet J, Bovee WMMJ, Foster MA (1988) Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. III. Multi-center trial with an in vitro NMR protocol. Magn Reson Imaging 6:185–194
Meiboom S, Gill D (1958) Modified spin echo method for measuring nuclear relaxation time. Rev Sci Instrum 29:688
Orr JS, Podo F (1988) Scientific report of the working group of the project and industry on harmonization of test procedures for performance assessment in MRI, Rome, 29 April, 1988, Eurospin Quarterly 17:21–115
Podo F (1985) The European concerted research project on identification and characterization of biological tissues by nuclear magnetic resonance. J Med Eng Technol 9:117–122
Podo F, Orr JS (eds) (1983) Proceedings of the EEC Workshop “Identification and characterization of biological tissues by NMR” Rome, 18–20 May, 1983. Ann 1st Super Sanita 19:1–214
Podo F, Orr JS, Schmidt KH, Bovée WMMJ (1988) Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. I. Introduction, objectives and activities. Magn Reson Imaging 6:175–178
Slichter CP (1963) Principles of magnetic resonance. Harper, New York
Walker PM, Lerski RA, Mathur-De Vré R, Binet J, Yane F (1988) Identification and characterization of biological tissues by NMR. Concerted research project of the European Economic Community. VI. Preparation of agarose gels as reference substances for NMR relaxation time measurement. Magn Reson Imaging 6:215–222
Young IR (1987) Development of tissue contrast in magnetic resonance imaging. In: Foster MA, Hutchison JMS. (eds) Practical NMR imaging. IRL Press, Washington, DC, pp 145–171
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© 1990 Springer-Verlag Berlin Heidelberg
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Podo, F. (1990). General Need for Quantitative Methodologies in Tissue Characterization by MRI. In: Higer, H.P., Bielke, G. (eds) Tissue Characterization in MR Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74993-3_2
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DOI: https://doi.org/10.1007/978-3-642-74993-3_2
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