Abstract
Prolongation of both the spin-lattice (T1) and the spin-spin (T2) proton relaxation times of neoplastic tissue in vitro was first reported by Damadian in 1971. In a majority of in vivo relaxation studies it was assumed that T1 and T2 relaxation curves behave as a simple monoexponential. However, T2 relaxation curves were found to be more complicated for various tissues. There are at least two reasons for observation of multiexponential relaxation behavior: (a) the spin system of one tissue type consists of different compartments, where each compartment contributes with a distinct component to the multi-exponential decay and/or (b) the voxels contain contributions from several tissues, the overall relaxation being a composite of the relaxation of the individual components (partial volume effect).
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References
Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171:1151–1153
Marquart DW (1963) An algorithm for least squares estimation of non-linear parameters. J Soc Industr Appl Math 11:431–441
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© 1990 Springer-Verlag Berlin Heidelberg
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Schad, L.R., Brix, G., Zuna, I., Härle, W., Semmler, W., Lorenz, W.J. (1990). Multiexponential Relaxation Analysis of Precontrast MRI in Comparison with Gadolinium-DTPA MRI. In: Higer, H.P., Bielke, G. (eds) Tissue Characterization in MR Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74993-3_16
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DOI: https://doi.org/10.1007/978-3-642-74993-3_16
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