Abstract
The infectious agent most frequently causing congenital malformations is the human cytomegalovirus (HCMV). HCMV infection is found in about 1% of newborns, and about 10%–15% of the infected children suffer either from immediate symptoms or late sequelae of the infection. Clinically apparent infections after birth are characterized by cytomegalic inclusion diseases (CIDs) in about 5% of the infected children. Another 5% have atypical involvement, usually with some damage of the CNS and 90% have no symptoms at birth. Among the most severely affected children mortality may be 30%. About 10%–15% of the children who are infected but asymptomatic at birth eventually develop mental retardation, chorioretinitis, microcephaly, and hearing loss (Weller 1971; Pass et al. 1980; Stagno et al. 1983, 1984).
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© 1990 Springer-Verlag Berlin Heidelberg
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Gönczöl, E., Plotkin, S. (1990). Progress in Vaccine Development for Prevention of Human Cytomegalovirus Infection. In: McDougall, J.K. (eds) Cytomegaloviruses. Current Topics in Microbiology and Immunology, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74980-3_10
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DOI: https://doi.org/10.1007/978-3-642-74980-3_10
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