Abstract
Mice homozygous for the scid mutation are characterized by the absence of functional B and T cells (Bosma et al. 1983; Dorshkind et al. 1984; Custer et al. 1985). Most scid mice do not possess detectable serum immunoglobulin (Bosma et al. 1983). The exact nature of the scid defect is not yet known but considerable evidence suggests that it may be due to a defective recombinase system which precludes the functional rearrangement of antigen receptor genes for B and T cells (Schuler et al. 1986; Kim et al. 1988; Malynn et al. 1988; Okazaki et al. 1988).
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© 1989 Springer-Verlag Berlin · Heidelberg
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Gibson, D.M., Bosma, G.C., Bosma, M.J. (1989). Limited Clonal Diversity of Serum Immunoglobulin in Leaky Scid Mice. In: Bosma, M.J., Phillips, R.A., Schuler, W. (eds) The Scid Mouse. Current Topics in Microbiology and Immunology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74974-2_16
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DOI: https://doi.org/10.1007/978-3-642-74974-2_16
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