Abstract
Organic solvents may exert their anaesthetic effect on central nervous tissue by affecting the cell membrane integral enzymes, which regulate the ion transport through the membrane (Korpela and Tähti 1986). In the present study, the effect of n-hexane and its metabolites 2,5-hexanedione, 2-hexanol and 2-hexanone on membrane acetylcholinesterase (AChE) were studied.
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References
Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95
Korpela M, Tähti H (1986) The effect of selected organic solvents on intact human red cell membrane acetylcholinesterase in vitro. Toxicol Appl Pharmacol 85:257–262
Korpela M, Tähti H (1988) Human and rat erythrocyte membrane as a model for studying the effects of organic solvents on membrane-bound acetylcholinesterase in vitro. In Vitro Toxicol 2:135–137
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© 1991 Springer-Verlag Berlin Heidelberg
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Rantanen, S., Hyppönen, S., Ahonen, I., Tähti, H. (1991). The Effects of n-Hexane and its Metabolites on Erythrocyte and Synaptosome Membrane Acetylcholinesterase in Vitro . In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_7
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DOI: https://doi.org/10.1007/978-3-642-74936-0_7
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