Some Effects of Furazolidone, Humic Acid and a Combination of Both on Male Reproduction in Rats

  • H. Zimmermann
  • S. Golbs
  • G. Gutte
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 14)

Abstract

Many methods are used to investigate possible effects of chemicals on male reproduction. Special questions arise in connection with chronic exposure to a substance and the exposure to several compounds. Histological investigations of the testes provide good results but are relatively time consuming. Mating studies require many animals and are not very sensitive because male rats are still fertile if sperm numbers are considerably decreased (Ettlin et al 1984; Russell and Ettlin 1989). Therefore it seems to be better to assess the sperm number in the epididymis and the morphology of mature sperm in the ductus deferens. The aims of this study were to estimate
  • the normal values for reproductive parameters of the inbreeding strain WIST/Lppt,

  • the sensitivity of this strain to a well known spermatoxic substance, furazolidone,

  • if a combination of humic acid with furazolidone would influence the reproductive effects of furazolidone.

Keywords

Toxicity Toxicology Carboxymethylcellulose Sulphasalazine Furazolidone 

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References

  1. Birnie G, McLeod T, Watkinson G (1981) Incidence of sulphasalazine-induced male infertility. Gut 22:452–455PubMedCrossRefGoogle Scholar
  2. Ettlin RA, Bechter R, Lee IP, Hodel C (1984) Aspects of testicular toxicity induced by anticancer drugs. Arch Toxicol Suppl 7:151–154PubMedCrossRefGoogle Scholar
  3. Heywood R, James RW (1978) Assessment of testicular toxicity in laboratory animals. Environ Health Perspect 24:73–80PubMedCrossRefGoogle Scholar
  4. Russell LD, Ettlin RA (1989) Histopathology of the testes. EST Training Session on Histological Evaluation of Spermatogenesis in Laboratory Animals 30 May 1989:17Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • H. Zimmermann
    • 1
  • S. Golbs
    • 1
  • G. Gutte
    • 2
  1. 1.Institute of Vet.-Pharmacology, Pharmacy and ToxicologyLeipzig UniversityLeipzigGermany
  2. 2.Institute of Vet.-Anatomy, Histology and EmbryologyLeipzig UniversityLeipzigGermany

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