Effect of Pyrazole on Dichloromethane Metabolism to Carbon Monoxide

  • D. Pankow
  • S. Kretschmer
  • M. Weise
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 14)

Abstract

The reports of elevated carboxyhemoglobin (COHb) levels following exposure to dichloromethane (DCM) stimulated the research on the toxicology of this solvent. The metabolic pathway of DCM to carbon monoxide (CO) involves an oxygen insertion catalyzed by cytochrome P-450 (Gargas et al 1986), mainly by the isozyme cytochrome P-450 IIE1 (CYP2E1). Pyrazole (PYR) is known to depress the oxidative metabolism of DCM, but based upon the catalytic, spectral, and immunological properties it appears to induce CYP2E1 (Palakodety et al 1988). The effect of PYR on carboxyhemoglobinemia following DCM administration in rats was investigated.

Keywords

Toxicity Acetone Depression Chrome Trichloromethane 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gargas ML, Clewell III HJ, Andersen ME (1986) Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways. Toxicol Appl Pharmacol 82:211–223PubMedCrossRefGoogle Scholar
  2. Kim YC, Carlson GP (1986) The effect of an unusual workshift on chemical toxicity I. Studies on the exposure of rats and mice to dichloromethane. Fund Appl Toxicol 6:162–171CrossRefGoogle Scholar
  3. Lieber CS, Rubin E, DeCarli LM, Misra PS, Gang H (1970) Effects of pyrazole on hepatic function and structure. Lab Invest 22:615–621PubMedGoogle Scholar
  4. Palakodety RB, Clejan LA, Krikun G, Feierman DE, Cederbaum AI (1988) Characterization and identification of a pyrazole-inducible form of cytochrome P-450. J Biol Chem 263:878–884PubMedGoogle Scholar
  5. Rydberg U, Buijten J, Neri A (1972) Kinetics of some pyrazole derivates in the rat. J Pharm Pharmacol 24:651–652PubMedCrossRefGoogle Scholar
  6. Schmidt P (1988) Biologische Kontrollmethoden in der Arbeitsmedizin. Verlag Volk und Gesundheit, Berlin, 345–346Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. Pankow
    • 1
  • S. Kretschmer
    • 1
  • M. Weise
    • 1
  1. 1.Institute of Industrial ToxicologyMartin Luther UniversityHalle/SGermany

Personalised recommendations