Effect of Pyrazole on Dichloromethane Metabolism to Carbon Monoxide
Part of the
Archives of Toxicology
book series (TOXICOLOGY, volume 14)
The reports of elevated carboxyhemoglobin (COHb) levels following exposure to dichloromethane (DCM) stimulated the research on the toxicology of this solvent. The metabolic pathway of DCM to carbon monoxide (CO) involves an oxygen insertion catalyzed by cytochrome P-450 (Gargas et al 1986), mainly by the isozyme cytochrome P-450 IIE1 (CYP2E1). Pyrazole (PYR) is known to depress the oxidative metabolism of DCM, but based upon the catalytic, spectral, and immunological properties it appears to induce CYP2E1 (Palakodety et al 1988). The effect of PYR on carboxyhemoglobinemia following DCM administration in rats was investigated.
KeywordsCOHb Level Oxygen Insertion Carboxyhemoglobin Level Receive Saline Solution COHb Concentration
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